Keeping the eIF2 alpha kinase Gcn2 in check BA Castilho, R Shanmugam, RC Silva, R Ramesh, BM Himme, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (9), 1948-1968, 2014 | 305 | 2014 |
Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid‐starved cells E Sattlegger, AG Hinnebusch The EMBO Journal, 2000 | 164 | 2000 |
Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2α kinase GCN2 during amino acid starvation E Sattlegger, AG Hinnebusch Journal of Biological Chemistry 280 (16), 16514-16521, 2005 | 98 | 2005 |
IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation CM Pereira, E Sattlegger, HY Jiang, BM Longo, CB Jaqueta, ... Journal of Biological Chemistry 280 (31), 28316-28323, 2005 | 96 | 2005 |
cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2α kinase and histidyl-tRNA synthetase-related domains required for general amino … E Sattlegger, AG Hinnebusch, IB Barthelmess Journal of Biological Chemistry 273 (32), 20404-20416, 1998 | 79 | 1998 |
YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed E Sattlegger, MJ Swanson, EA Ashcraft, JL Jennings, RA Fekete, AJ Link, ... Journal of Biological Chemistry 279 (29), 29952-29962, 2004 | 74 | 2004 |
The WD protein Cpc2p is required for repression of Gcn4 protein activity in yeast in the absence of amino‐acid starvation B Hoffmann, HU Mösch, E Sattlegger, IB Barthelmess, A Hinnebusch, ... Molecular microbiology 31 (3), 807-822, 1999 | 59 | 1999 |
Evidence That Eukaryotic Translation Elongation Factor 1A (eEF1A) Binds the Gcn2 Protein C Terminus and Inhibits Gcn2 Activity*♦ J Visweswaraiah, S Lageix, BA Castilho, L Izotova, TG Kinzy, ... Journal of Biological Chemistry 286 (42), 36568-36579, 2011 | 58 | 2011 |
Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior VS Alves, DC Pimenta, E Sattlegger, BA Castilho Biochemical and biophysical research communications 314 (1), 229-234, 2004 | 53 | 2004 |
The cpc-2 gene ofNeurospora crassa encodes a protein entirely composed of WD-repeat segments that is involved in general amino acid control and female fertility F Müller, D Krüger, E Sattlegger, B Hoffmann, P Ballario, M Kanaan, ... Molecular and General Genetics MGG 248, 162-173, 1995 | 52 | 1995 |
Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2 E Sattlegger, JARG Barbosa, MCS Moraes, RM Martins, AG Hinnebusch, ... Journal of Biological Chemistry 286 (12), 10341-10355, 2011 | 48 | 2011 |
Saccharomyces cerevisiae Rbg1 Protein and Its Binding Partner Gir2 Interact on Polyribosomes with Gcn1 PK Wout, E Sattlegger, SM Sullivan, JR Maddock Eukaryotic cell 8 (7), 1061-1071, 2009 | 46 | 2009 |
Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response RC Silva, E Sattlegger, BA Castilho Journal of Cell Science 129 (24), 4521-4533, 2016 | 43 | 2016 |
Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2 TD Cambiaghi, CM Pereira, R Shanmugam, M Bolech, RC Wek, ... Biochemical and biophysical research communications 443 (2), 592-597, 2014 | 42 | 2014 |
Transcriptional defect of an inherited NKX2-5 haplotype comprising a SNP, a nonsynonymous and a synonymous mutation, associated with human congenital heart disease SM Reamon-Buettner, E Sattlegger, Y Ciribilli, A Inga, A Wessel, J Borlak PLoS One 8 (12), e83295, 2013 | 38 | 2013 |
Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation J Visweswaraiah, SJ Lee, AG Hinnebusch, E Sattlegger Journal of Biological Chemistry 287 (45), 37757-37768, 2012 | 28 | 2012 |
Yeast as a model to understand actin-mediated cellular functions in mammals—illustrated with four actin cytoskeleton proteins Z Akram, I Ahmed, H Mack, R Kaur, RC Silva, BA Castilho, S Friant, ... Cells 9 (3), 672, 2020 | 25 | 2020 |
Damaging de novo missense variants in EEF1A2 lead to a developmental and degenerative epileptic‐dyskinetic encephalopathy GL Carvill, KL Helbig, CT Myers, M Scala, R Huether, S Lewis, TN Kruer, ... Human mutation 41 (7), 1263-1279, 2020 | 24 | 2020 |
Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2 SJ Lee, MJ Swanson, E Sattlegger Biochemical Journal 466 (3), 547-559, 2015 | 24 | 2015 |
Evidence that Yih1 resides in a complex with ribosomes T Waller, SJ Lee, E Sattlegger The FEBS journal 279 (10), 1761-1776, 2012 | 22 | 2012 |