Tuning P450 enzymes as oxidation catalysts R Fasan Acs Catalysis 2 (4), 647-666, 2012 | 396 | 2012 |
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties R Fasan, MM Chen, NC Crook, FH Arnold Angewandte Chemie International Edition 46 (44), 8414-8418, 2007 | 323 | 2007 |
Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions OF Brandenberg, R Fasan, FH Arnold Current opinion in biotechnology 47, 102-111, 2017 | 308 | 2017 |
Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin‐based catalysts M Bordeaux, V Tyagi, R Fasan Angewandte Chemie 127 (6), 1764-1768, 2015 | 306 | 2015 |
Molecular basis of RNA recognition by the human alternative splicing factor Fox‐1 SD Auweter, R Fasan, L Reymond, JG Underwood, DL Black, S Pitsch, ... The EMBO journal 25 (1), 163-173, 2006 | 301 | 2006 |
Evolutionary history of a specialized P450 propane monooxygenase R Fasan, YT Meharenna, CD Snow, TL Poulos, FH Arnold Journal of molecular biology 383 (5), 1069-1080, 2008 | 263 | 2008 |
Using a b-hairpin to mimic an a-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction R Fasan, RLA Dias, K Moehle, O Zerbe, JW Vrijbloed, D Obrecht, ... Angewandte Chemie-International Edition 43 (16), 2109-2112, 2004 | 248 | 2004 |
Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity K Zhang, BM Shafer, MD Demars, HA Stern, R Fasan Journal of the American Chemical Society 134 (45), 18695-18704, 2012 | 208 | 2012 |
P450-Catalyzed Intramolecular sp3 C–H Amination with Arylsulfonyl Azide Substrates R Singh, M Bordeaux, R Fasan ACS catalysis 4 (2), 546-552, 2014 | 191 | 2014 |
Intermolecular carbene S–H insertion catalysed by engineered myoglobin-based catalysts V Tyagi, RB Bonn, R Fasan Chemical science 6 (4), 2488-2494, 2015 | 190 | 2015 |
Highly diastereo-and enantioselective synthesis of trifluoromethyl-substituted cyclopropanes via myoglobin-catalyzed transfer of trifluoromethylcarbene A Tinoco, V Steck, V Tyagi, R Fasan Journal of the American Chemical Society 139 (15), 5293-5296, 2017 | 180 | 2017 |
Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates G Sreenilayam, R Fasan Chemical Communications 51 (8), 1532-1534, 2015 | 178 | 2015 |
Structure–activity studies in a family of β‐Hairpin protein epitope mimetic inhibitors of the p53–HDM2 protein–protein interaction R Fasan, RLA Dias, K Moehle, O Zerbe, D Obrecht, PRE Mittl, MG Grütter, ... ChemBioChem 7 (3), 515-526, 2006 | 176 | 2006 |
Gram‐scale synthesis of chiral cyclopropane‐containing drugs and drug precursors with engineered myoglobin catalysts featuring complementary stereoselectivity P Bajaj, G Sreenilayam, V Tyagi, R Fasan Angewandte Chemie 128 (52), 16344-16348, 2016 | 173 | 2016 |
Enzymatic C(sp3)-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones R Singh, JN Kolev, PA Sutera, R Fasan ACS catalysis 5 (3), 1685-1691, 2015 | 168 | 2015 |
Chemo-enzymatic fluorination of unactivated organic compounds A Rentmeister, FH Arnold, R Fasan Nature Chemical Biology 5 (1), 26-28, 2009 | 153 | 2009 |
Intramolecular C (sp3) H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts M Bordeaux, R Singh, R Fasan Bioorganic & medicinal chemistry 22 (20), 5697-5704, 2014 | 142 | 2014 |
Metal substitution modulates the reactivity and extends the reaction scope of myoglobin carbene transfer catalysts G Sreenilayam, EJ Moore, V Steck, R Fasan Advanced synthesis & catalysis 359 (12), 2076-2089, 2017 | 139 | 2017 |
P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity K Zhang, S El Damaty, R Fasan Journal of the American Chemical Society 133 (10), 3242-3245, 2011 | 139 | 2011 |
Myoglobin‐Catalyzed C− H Functionalization of Unprotected Indoles DA Vargas, A Tinoco, V Tyagi, R Fasan Angewandte Chemie International Edition 57 (31), 9911-9915, 2018 | 136 | 2018 |