| α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models AA Cooper, AD Gitler, A Cashikar, CM Haynes, KJ Hill, B Bhullar, K Liu, ... Science 313 (5785), 324-328, 2006 | 1512 | 2006 |
| Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS HJ Kim, NC Kim, YD Wang, EA Scarborough, J Moore, Z Diaz, ... Nature 495 (7442), 467-473, 2013 | 1252 | 2013 |
| Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS AC Elden, HJ Kim, MP Hart, AS Chen-Plotkin, BS Johnson, X Fang, ... Nature 466 (7310), 1069-1075, 2010 | 1159 | 2010 |
| Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways ET Cirulli, BN Lasseigne, S Petrovski, PC Sapp, PA Dion, CS Leblond, ... Science 347 (6229), 1436-1441, 2015 | 823 | 2015 |
| Stress granules as crucibles of ALS pathogenesis YR Li, OD King, J Shorter, AD Gitler Journal of cell biology 201 (3), 361-372, 2013 | 798 | 2013 |
| TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity BS Johnson, D Snead, JJ Lee, JM McCaffery, J Shorter, AD Gitler Journal of Biological Chemistry 284 (30), 20329-20339, 2009 | 710 | 2009 |
| The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease OD King, AD Gitler, J Shorter Brain research 1462, 61-80, 2012 | 615 | 2012 |
| The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis AD Gitler, BJ Bevis, J Shorter, KE Strathearn, S Hamamichi, LJ Su, ... Proceedings of the National Academy of Sciences 105 (1), 145-150, 2008 | 579 | 2008 |
| α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity AD Gitler, A Chesi, ML Geddie, KE Strathearn, S Hamamichi, KJ Hill, ... Nature genetics 41 (3), 308-315, 2009 | 566 | 2009 |
| Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS A Jovičić, J Mertens, S Boeynaems, E Bogaert, N Chai, SB Yamada, ... Nature neuroscience 18 (9), 1226-1229, 2015 | 522 | 2015 |
| A suite of Gateway® cloning vectors for high‐throughput genetic analysis in Saccharomyces cerevisiae S Alberti, AD Gitler, S Lindquist Yeast 24 (10), 913-919, 2007 | 468 | 2007 |
| A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity BS Johnson, JM McCaffery, S Lindquist, AD Gitler Proceedings of the National Academy of Sciences 105 (17), 6439-6444, 2008 | 452 | 2008 |
| Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS Z Sun, Z Diaz, X Fang, MP Hart, A Chesi, J Shorter, AD Gitler PLoS biology 9 (4), e1000614, 2011 | 450 | 2011 |
| Neurodegenerative disease: models, mechanisms, and a new hope AD Gitler, P Dhillon, J Shorter Disease models & mechanisms 10 (5), 499-502, 2017 | 418 | 2017 |
| Semaphorin-plexin signaling guides patterning of the developing vasculature J Torres-Vázquez, AD Gitler, SD Fraser, JD Berk, VN Pham, MC Fishman, ... Developmental cell 7 (1), 117-123, 2004 | 407 | 2004 |
| A yeast functional screen predicts new candidate ALS disease genes J Couthouis, MP Hart, J Shorter, M DeJesus-Hernandez, R Erion, ... Proceedings of the National Academy of Sciences 108 (52), 20881-20890, 2011 | 401 | 2011 |
| PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development AD Gitler, MM Lu, JA Epstein Developmental cell 7 (1), 107-116, 2004 | 380 | 2004 |
| Genome-wide analyses identify KIF5A as a novel ALS gene A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ... Neuron 97 (6), 1268-1283. e6, 2018 | 373 | 2018 |
| Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice LA Becker, B Huang, G Bieri, R Ma, DA Knowles, P Jafar-Nejad, ... Nature 544 (7650), 367-371, 2017 | 372 | 2017 |
| Defects in trafficking bridge Parkinson's disease pathology and genetics A Abeliovich, AD Gitler Nature 539 (7628), 207-216, 2016 | 365 | 2016 |
