| Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders P Jeffrey Conn, A Christopoulos, CW Lindsley Nature reviews Drug discovery 8 (1), 41-54, 2009 | 1180 | 2009 |
| Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors CW Lindsley, Z Zhao, WH Leister, RG Robinson, SF Barnett, ... Bioorganic & medicinal chemistry letters 15 (3), 761-764, 2005 | 657 | 2005 |
| The Akt/PKB pathway: molecular target for cancer drug discovery JQ Cheng, CW Lindsley, GZ Cheng, H Yang, SV Nicosia Oncogene 24 (50), 7482-7492, 2005 | 605 | 2005 |
| Efficient synthesis of imidazoles from aldehydes and 1, 2-diketones using microwave irradiation SE Wolkenberg, DD Wisnoski, WH Leister, Y Wang, Z Zhao, CW Lindsley Organic Letters 6 (9), 1453-1456, 2004 | 538 | 2004 |
| In Vivo Structure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors J Hao, JN Ho, JA Lewis, KA Karim, RN Daniels, PR Gentry, CR Hopkins, ... ACS chemical biology 5 (2), 245-253, 2010 | 435 | 2010 |
| Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia PJ Conn, CW Lindsley, CK Jones Trends in pharmacological sciences 30 (1), 25-31, 2009 | 412 | 2009 |
| Phospholipase D: enzymology, functionality, and chemical modulation PE Selvy, RR Lavieri, CW Lindsley, HA Brown Chemical reviews 111 (10), 6064-6119, 2011 | 379 | 2011 |
| A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models GG Kinney, JA O'Brien, W Lemaire, M Burno, DJ Bickel, MK Clements, ... Journal of Pharmacology and Experimental Therapeutics 313 (1), 199-206, 2005 | 344 | 2005 |
| General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines Z Zhao, DD Wisnoski, SE Wolkenberg, WH Leister, Y Wang, CW Lindsley Tetrahedron Letters 45 (25), 4873-4876, 2004 | 315 | 2004 |
| Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders PJ Conn, CK Jones, CW Lindsley Trends in pharmacological sciences 30 (3), 148-155, 2009 | 310 | 2009 |
| The ecstasy and agony of assay interference compounds C Aldrich, C Bertozzi, GI Georg, L Kiessling, C Lindsley, D Liotta, ... ACS Chemical Neuroscience 8 (3), 420-423, 2017 | 301 | 2017 |
| Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation L Ma, MA Seager, M Wittmann, M Jacobson, D Bickel, M Burno, K Jones, ... Proceedings of the National Academy of Sciences 106 (37), 15950-15955, 2009 | 301 | 2009 |
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness SA Scott, PE Selvy, JR Buck, HP Cho, TL Criswell, AL Thomas, ... Nature chemical biology 5 (2), 108-117, 2009 | 294 | 2009 |
| Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats CK Jones, AE Brady, AA Davis, Z Xiang, M Bubser, MN Tantawy, AS Kane, ... Journal of Neuroscience 28 (41), 10422-10433, 2008 | 282 | 2008 |
| A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 JA O'Brien, W Lemaire, TB Chen, RSL Chang, MA Jacobson, SN Ha, ... Molecular pharmacology 64 (3), 731-740, 2003 | 280 | 2003 |
| Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders PJ Conn, CW Lindsley, J Meiler, CM Niswender Nature reviews Drug discovery 13 (9), 692-708, 2014 | 274 | 2014 |
| Application of combinatorial chemistry science on modern drug discovery JP Kennedy, L Williams, TM Bridges, RN Daniels, D Weaver, CW Lindsley Journal of combinatorial chemistry 10 (3), 345-354, 2008 | 267 | 2008 |
| Drugs for allosteric sites on receptors CJ Wenthur, PR Gentry, TP Mathews, CW Lindsley Annual review of pharmacology and toxicology 54, 165-184, 2014 | 265 | 2014 |
| Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery BJ Melancon, CR Hopkins, MR Wood, KA Emmitte, CM Niswender, ... Journal of medicinal chemistry 55 (4), 1445-1464, 2012 | 254 | 2012 |
| A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal … JK Shirey, AE Brady, PJ Jones, AA Davis, TM Bridges, JP Kennedy, ... Journal of Neuroscience 29 (45), 14271-14286, 2009 | 254 | 2009 |
conn pjLee E. Limbird Professor, Director, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt UniversityVerified email at vanderbilt.edu
