| Structure-based discovery of opioid analgesics with reduced side effects A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ... Nature 537 (7619), 185-190, 2016 | 955 | 2016 |
| Activation and allosteric modulation of a muscarinic acetylcholine receptor AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ... Nature 504 (7478), 101-106, 2013 | 940 | 2013 |
| Structure and function of an irreversible agonist-β2 adrenoceptor complex DM Rosenbaum, C Zhang, JA Lyons, R Holl, D Aragao, DH Arlow, ... Nature 469 (7329), 236-240, 2011 | 908 | 2011 |
| Structural insights into µ-opioid receptor activation W Huang, A Manglik, AJ Venkatakrishnan, T Laeremans, EN Feinberg, ... Nature 524 (7565), 315-321, 2015 | 884 | 2015 |
| Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists L Bettinetti, K Schlotter, H Hübner, P Gmeiner Journal of medicinal chemistry 45 (21), 4594-4597, 2002 | 228 | 2002 |
| Click linker: Efficient and high-yielding synthesis of a new family of SPOS resins by 1, 3-dipolar cycloaddition S Löber, P Rodriguez-Loaiza, P Gmeiner Organic Letters 5 (10), 1753-1755, 2003 | 220 | 2003 |
| Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially … H Hübner, C Haubmann, W Utz, P Gmeiner Journal of medicinal chemistry 43 (4), 756-762, 2000 | 193 | 2000 |
| Class A G-protein-coupled receptor (GPCR) dimers and bivalent ligands C Hiller, J Kühhorn, P Gmeiner Journal of medicinal chemistry 56 (17), 6542-6559, 2013 | 149 | 2013 |
| An efficient and practical total synthesis of (+)-vincamine from L-aspartic acid P Gmeiner, PL Feldman, MY Chu-Moyer, H Rapoport The Journal of Organic Chemistry 55 (10), 3068-3074, 1990 | 148 | 1990 |
| Labeling and Glycosylation of Peptides Using Click Chemistry: A General Approach to 18F‐Glycopeptides as Effective Imaging Probes for Positron Emission … S Maschauer, J Einsiedel, R Haubner, C Hocke, M Ocker, H Hübner, ... Angewandte Chemie International Edition 5 (49), 976-979, 2010 | 144 | 2010 |
| GPCR crystal structures: medicinal chemistry in the pocket J Shonberg, RC Kling, P Gmeiner, S Löber Bioorganic & medicinal chemistry 23 (14), 3880-3906, 2015 | 134 | 2015 |
| Chirospecific synthesis of spirocyclic β-lactams and their characterization as potent type ii β-turn inducing peptide mimetics H Bittermann, P Gmeiner The Journal of organic chemistry 71 (1), 97-102, 2006 | 122 | 2006 |
| Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps S Löber, H Hübner, P Gmeiner Bioorganic & medicinal chemistry letters 9 (1), 97-102, 1999 | 121 | 1999 |
| Recent advances in the search for D3-and D4-selective drugs: probes, models and candidates S Löber, H Hübner, N Tschammer, P Gmeiner Trends in pharmacological sciences 32 (3), 148-157, 2011 | 117 | 2011 |
| Covalent agonists for studying G protein-coupled receptor activation D Weichert, AC Kruse, A Manglik, C Hiller, C Zhang, H Hübner, ... Proceedings of the National Academy of Sciences 111 (29), 10744-10748, 2014 | 116 | 2014 |
| Rationally based efficacy tuning of selective dopamine D4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl) piperazin-1-ylmethyl] pyrazolo [1, 5-a … S Löber, H Hübner, W Utz, P Gmeiner Journal of medicinal chemistry 44 (17), 2691-2694, 2001 | 115 | 2001 |
| Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent‐resistant membrane compartments R Klingenstein, S Löber, P Kujala, S Godsave, SR Leliveld, P Gmeiner, ... Journal of neurochemistry 98 (3), 748-759, 2006 | 113 | 2006 |
| The structural evolution of dopamine D3 receptor ligands: structure–activity relationships and selected neuropharmacological aspects F Boeckler, P Gmeiner Pharmacology & therapeutics 112 (1), 281-333, 2006 | 112 | 2006 |
| Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level A Tabor, S Weisenburger, A Banerjee, N Purkayastha, JM Kaindl, ... Scientific reports 6 (1), 33233, 2016 | 106 | 2016 |
| Dopamine D2, D3, and D4 Selective Phenylpiperazines as Molecular Probes To Explore the Origins of Subtype Specific Receptor Binding K Ehrlich, A Gotz, S Bollinger, N Tschammer, L Bettinetti, S Harterich, ... Journal of medicinal chemistry 52 (15), 4923-4935, 2009 | 104 | 2009 |
