Margot Ernst
Margot Ernst
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Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands
L Richter, C De Graaf, W Sieghart, Z Varagic, M Mörzinger, IJP De Esch, ...
Nature chemical biology 8 (5), 455, 2012
The benzodiazepine binding sites of GABAA receptors
E Sigel, M Ernst
Trends in pharmacological sciences 39 (7), 659-671, 2018
Comparative modeling of GABAA receptors: limits, insights, future developments
M Ernst, D Brauchart, S Boresch, W Sieghart
Neuroscience 119 (4), 933-943, 2003
Comparative models of GABAA receptor extracellular and transmembrane domains: important insights in pharmacology and function
M Ernst, S Bruckner, S Boresch, W Sieghart
Molecular pharmacology 68 (5), 1291-1300, 2005
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines
R Spurny, J Ramerstorfer, K Price, M Brams, M Ernst, H Nury, M Verheij, ...
Proceedings of the National Academy of Sciences 109 (44), E3028-E3034, 2012
The GABAA receptor α+ β− interface: a novel target for subtype selective drugs
J Ramerstorfer, R Furtmüller, I Sarto-Jackson, Z Varagic, W Sieghart, ...
Journal of neuroscience 31 (3), 870-877, 2011
A novel GABAA receptor pharmacology: drugs interacting with the α+ β‐interface
W Sieghart, J Ramerstorfer, I Sarto‐Jackson, Z Varagic, M Ernst
British journal of pharmacology 166 (2), 476-485, 2012
An updated unified pharmacophore model of the benzodiazepine binding site on γ-aminobutyric acida receptors: correlation with comparative models
T Clayton, JL Chen, M Ernst, L Richter, BA Cromer, CJ Morton, H Ng, ...
Current medicinal chemistry 14 (26), 2755-2775, 2007
Structural studies of GABAA receptor binding sites: which experimental structure tells us what?
R Puthenkalam, M Hieckel, X Simeone, C Suwattanasophon, ...
Frontiers in molecular neuroscience 9, 44, 2016
Heterogeneity of GABAA receptors: revived interest in the development of subtype-selective drugs
W Sieghart, M Ernst
Current Medicinal Chemistry-Central Nervous System Agents 5 (3), 217-242, 2005
Subtype selectivity of α+ β− site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors
Z Varagic, J Ramerstorfer, S Huang, S Rallapalli, I Sarto‐Jackson, J Cook, ...
British journal of pharmacology 169 (2), 384-399, 2013
GABAA Receptors
M Ernst, F Steudle, K Bampali
eLS, 0
Computational thermochemistry of medium-sized silicon hydrides
G Katzer, MC Ernst, AF Sax, J Kalcher
The Journal of Physical Chemistry A 101 (21), 3942-3958, 1997
Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor γ2 subunit
W Ogris, A Pöltl, B Hauer, M Ernst, A Oberto, P Wulff, H Höger, W Wisden, ...
Biochemical pharmacology 68 (8), 1621-1629, 2004
Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+ β− interface
Z Varagic, L Wimmer, M Schnürch, MD Mihovilovic, S Huang, S Rallapalli, ...
British journal of pharmacology 169 (2), 371-383, 2013
Accepted Article
Z Varagic, L Wimmer, M Schnürch, MD Mihovilovic, S Huang, S Rallapalli, ...
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved …
DE Knutson, R Kodali, B Divović, M Treven, MR Stephen, NM Zahn, ...
Journal of medicinal chemistry, 2018
Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit
TT Stamenić, MM Poe, S Rehman, A Santrač, B Divović, P Scholze, ...
European journal of pharmacology 791, 433-443, 2016
α subunits in GABA A receptors are dispensable for GABA and diazepam action
N Wongsamitkul, MC Maldifassi, X Simeone, R Baur, M Ernst, E Sigel
Scientific Reports 7 (1), 15498, 2017
Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability …
MM Poe, KR Methuku, G Li, AR Verma, KA Teske, DC Stafford, LA Arnold, ...
Journal of medicinal chemistry 59 (23), 10800-10806, 2016
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