Karl Dykema
Karl Dykema
Computational Biologist @ Spectrum Health / Helen Devos Children's Hospital / Pediatric Oncology
Bestätigte E-Mail-Adresse bei spectrumhealth.org
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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
I Varela, P Tarpey, K Raine, D Huang, CK Ong, P Stephens, H Davies, ...
Nature 469 (7331), 539-542, 2011
11662011
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
I Varela, P Tarpey, K Raine, D Huang, CK Ong, P Stephens, H Davies, ...
Nature 469 (7331), 539-542, 2011
11662011
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
GL Dalgliesh, K Furge, C Greenman, L Chen, G Bignell, A Butler, ...
Nature 463 (7279), 360-363, 2010
11612010
Exome sequencing of liver fluke–associated cholangiocarcinoma
CK Ong, C Subimerb, C Pairojkul, S Wongkham, I Cutcutache, W Yu, ...
Nature genetics 44 (6), 690-693, 2012
3852012
Renal translocation carcinomas: clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature
P Camparo, V Vasiliu, V Molinie, J Couturier, KJ Dykema, D Petillo, ...
The American journal of surgical pathology 32 (5), 656-670, 2008
2522008
Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study
HJ Hammers, HM Verheul, B Salumbides, R Sharma, M Rudek, J Jaspers, ...
Molecular cancer therapeutics 9 (6), 1525-1535, 2010
1662010
Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma
KA Furge, J Chen, J Koeman, P Swiatek, K Dykema, K Lucin, R Kahnoski, ...
Cancer Research 67 (7), 3171-3176, 2007
1512007
Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations
CF Gao, K Furge, J Koeman, K Dykema, Y Su, ML Cutler, A Werts, P Haak, ...
Proceedings of the National Academy of Sciences 104 (21), 8995-9000, 2007
1492007
Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia
J Chen, K Futami, D Petillo, J Peng, P Wang, J Knol, Y Li, SK Khoo, ...
PloS one 3 (10), e3581, 2008
1442008
Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia
J Chen, K Futami, D Petillo, J Peng, P Wang, J Knol, Y Li, SK Khoo, ...
PloS one 3 (10), e3581, 2008
1442008
Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia
J Chen, K Futami, D Petillo, J Peng, P Wang, J Knol, Y Li, SK Khoo, ...
PloS one 3 (10), e3581, 2008
1442008
Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma
MA Patil, I Gütgemann, J Zhang, C Ho, ST Cheung, D Ginzinger, R Li, ...
Carcinogenesis 26 (12), 2050-2057, 2005
1442005
Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
CR Graveel, JD DeGroot, Y Su, J Koeman, K Dykema, S Leung, J Snider, ...
Proceedings of the National Academy of Sciences 106 (31), 12909-12914, 2009
1352009
The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development
C Lindvall, CR Zylstra, N Evans, RA West, K Dykema, KA Furge, ...
PloS one 4 (6), e5813, 2009
1342009
CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma
A Ooi, K Dykema, A Ansari, D Petillo, J Snider, R Kahnoski, J Anema, ...
Cancer research 73 (7), 2044-2051, 2013
1302013
Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation
D Bonte, C Lindvall, H Liu, K Dykema, K Furge, M Weinreich
Neoplasia (New York, NY) 10 (9), 920, 2008
1262008
Genome‐wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target
M Gerlinger, CR Santos, B Spencer‐Dene, P Martinez, D Endesfelder, ...
The Journal of pathology 227 (2), 146-156, 2012
1012012
Birt-Hogg-Dube renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression
JA Klomp, D Petillo, NM Niemi, KJ Dykema, J Chen, XJ Yang, A Sääf, ...
BMC medical genomics 3 (1), 1-12, 2010
922010
Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing
ZJ Zang, CK Ong, I Cutcutache, W Yu, SL Zhang, D Huang, LD Ler, ...
Cancer research 71 (1), 29-39, 2011
842011
Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response
Y He, Y Xu, C Zhang, X Gao, KJ Dykema, KR Martin, J Ke, EA Hudson, ...
Science signaling 4 (180), ra44-ra44, 2011
802011
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