| Restoration of p53 function leads to tumour regression in vivo A Ventura, DG Kirsch, ME McLaughlin, DA Tuveson, J Grimm, L Lintault, ... Nature 445 (7128), 661-665, 2007 | 1998 | 2007 |
| Conversion of Bcl-2 to a Bax-like death effector by caspases EHY Cheng, DG Kirsch, RJ Clem, R Ravi, MB Kastan, A Bedi, K Ueno, ... Science 278 (5345), 1966-1968, 1997 | 1576 | 1997 |
| Modulation of cell death by Bcl-xL through caspase interaction RJ Clem, EHY Cheng, CL Karp, DG Kirsch, K Ueno, A Takahashi, ... Proceedings of the National Academy of Sciences 95 (2), 554-559, 1998 | 702 | 1998 |
| Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c DG Kirsch, A Doseff, BN Chau, DS Lim, NC de Souza-Pinto, R Hansford, ... Journal of Biological Chemistry 274 (30), 21155-21161, 1999 | 623 | 1999 |
| Dicer1 functions as a haploinsufficient tumor suppressor MS Kumar, RE Pester, CY Chen, K Lane, C Chin, J Lu, DG Kirsch, ... Genes & development 23 (23), 2700-2704, 2009 | 531 | 2009 |
| Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2–positive breast cancer NU Lin, LA Carey, MC Liu, J Younger, SE Come, M Ewend, GJ Harris, ... Journal of clinical oncology: official journal of the American Society of …, 2008 | 515 | 2008 |
| Animal models for medical countermeasures to radiation exposure JP Williams, SL Brown, GE Georges, M Hauer-Jensen, RP Hill, AK Huser, ... Radiation research 173 (4), 557-578, 2010 | 463 | 2010 |
| Strategies for optimizing the response of cancer and normal tissues to radiation EJ Moding, MB Kastan, DG Kirsch Nature reviews Drug discovery 12 (7), 526-542, 2013 | 420 | 2013 |
| Tumor-suppressor p53: implications for tumor development and prognosis. DG Kirsch, MB Kastan Journal of clinical oncology 16 (9), 3158-3168, 1998 | 400 | 1998 |
| Dietary methionine influences therapy in mouse cancer models and alters human metabolism X Gao, SM Sanderson, Z Dai, MA Reid, DE Cooper, M Lu, JP Richie Jr, ... Nature 572 (7769), 397-401, 2019 | 370 | 2019 |
| A spatially and temporally restricted mouse model of soft tissue sarcoma DG Kirsch, DM Dinulescu, JB Miller, J Grimm, PM Santiago, NP Young, ... Nature medicine 13 (8), 992-997, 2007 | 331 | 2007 |
| Treatment and outcome of 82 patients with angiosarcoma JA Abraham, FJ Hornicek, AM Kaufman, DC Harmon, DS Springfield, ... Annals of surgical oncology 14, 1953-1967, 2007 | 310 | 2007 |
| A plasmonic gold nanostar theranostic probe for in vivo tumor imaging and photothermal therapy Y Liu, JR Ashton, EJ Moding, H Yuan, JK Register, AM Fales, J Choi, ... Theranostics 5 (9), 946, 2015 | 265 | 2015 |
| p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis DG Kirsch, PM Santiago, E di Tomaso, JM Sullivan, WS Hou, T Dayton, ... Science 327 (5965), 593, 2010 | 250 | 2010 |
| Acetate production from glucose and coupling to mitochondrial metabolism in mammals X Liu, DE Cooper, AA Cluntun, MO Warmoes, S Zhao, MA Reid, J Liu, ... Cell 175 (2), 502-513. e13, 2018 | 235 | 2018 |
| Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology … DP Nussbaum, CN Rushing, WO Lane, DM Cardona, DG Kirsch, ... The Lancet Oncology 17 (7), 966-975, 2016 | 234 | 2016 |
| Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis TSK Eisinger-Mathason, M Zhang, Q Qiu, N Skuli, MS Nakazawa, ... Cancer discovery 3 (10), 1190-1205, 2013 | 234 | 2013 |
| Significant reduction of late toxicities in patients with extremity sarcoma treated with image-guided radiation therapy to a reduced target volume: results of radiation therapy … D Wang, Q Zhang, BL Eisenberg, JM Kane, XA Li, D Lucas, IA Petersen, ... Journal of Clinical Oncology 33 (20), 2231, 2015 | 229 | 2015 |
| A next-generation dual-recombinase system for time-and host-specific targeting of pancreatic cancer N Schönhuber, B Seidler, K Schuck, C Veltkamp, C Schachtler, ... Nature medicine 20 (11), 1340-1347, 2014 | 228 | 2014 |
| A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer MJ Whitley, DM Cardona, AL Lazarides, I Spasojevic, JM Ferrer, J Cahill, ... Science translational medicine 8 (320), 320ra4-320ra4, 2016 | 218 | 2016 |
