K. Christopher Garcia
K. Christopher Garcia
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Accurate prediction of protein structures and interactions using a three-track neural network
M Baek, F DiMaio, I Anishchenko, J Dauparas, S Ovchinnikov, GR Lee, ...
Science 373 (6557), 871-876, 2021
An αβ T cell receptor structure at 2.5 ┼ and its orientation in the TCR-MHC complex
KC Garcia, M Degano, RL Stanfield, A Brunmark, MR Jackson, ...
Science 274 (5285), 209-219, 1996
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
CY Park, PJ Hoover, FM Mullins, P Bachhawat, ED Covington, S Raunser, ...
Cell 136 (5), 876-890, 2009
Gabapentin receptor α2δ-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis
C Eroglu, NJ Allen, MW Susman, NA O'Rourke, CY Park, E Ízkan, ...
Cell 139 (2), 380-392, 2009
Structural basis of Wnt recognition by Frizzled
CY Janda, D Waghray, AM Levin, C Thomas, KC Garcia
Science 337 (6090), 59-64, 2012
Activation and allosteric modulation of a muscarinic acetylcholine receptor
AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H HŘbner, E Pardon, ...
Nature 504 (7478), 101-106, 2013
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
KC Garcia, M Degano, LR Pease, M Huang, PA Peterson, L Teyton, ...
Science 279 (5354), 1166-1172, 1998
Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/gp130 complex
MJ Boulanger, D Chow, EE Brevnova, KC Garcia
Science 300 (5628), 2101-2104, 2003
Mutational signature in colorectal cancer caused by genotoxic pks+E. coli
C Pleguezuelos-Manzano, J Puschhof, A Rosendahl Huber, A van Hoeck, ...
Nature 580 (7802), 269-273, 2020
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
JA Fraietta, CL Nobles, MA Sammons, S Lundh, SA Carty, TJ Reich, ...
Nature 558 (7709), 307-312, 2018
Structural basis of T cell recognition
KC Garcia, L Teyton, IA Wilson
Annual review of immunology 17 (1), 369-397, 1999
Deconstructing the peptide-MHC specificity of T cell recognition
ME Birnbaum, JL Mendoza, DK Sethi, S Dong, J Glanville, J Dobbins, ...
Cell 157 (5), 1073-1087, 2014
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
SL LaPorte, ZS Juo, J Vaclavikova, LA Colf, X Qi, NM Heller, AD Keegan, ...
Cell 132 (2), 259-272, 2008
Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
AM Levin, DL Bates, AM Ring, C Krieg, JT Lin, L Su, I Moraga, ME Raeber, ...
Nature 484 (7395), 529-533, 2012
Structure of the Quaternary Complex of Interleukin-2 with Its α, ▀, and γc Receptors
X Wang, M Rickert, KC Garcia
Science 310 (5751), 1159-1163, 2005
Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
AM Ring, A Manglik, AC Kruse, MD Enos, WI Weis, KC Garcia, BK Kobilka
Nature 502 (7472), 575-579, 2013
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
A Goehring, CH Lee, KH Wang, JC Michel, DP Claxton, I Baconguis, ...
Nature protocols 9 (11), 2574-2585, 2014
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies
K Weiskopf, AM Ring, CCM Ho, JP Volkmer, AM Levin, AK Volkmer, ...
Science 341 (6141), 88-91, 2013
The composition and signaling of the IL-35 receptor are unconventional
LW Collison, GM Delgoffe, CS Guy, KM Vignali, V Chaturvedi, ...
Nature immunology 13 (3), 290-299, 2012
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM
TV Lanz, RC Brewer, PP Ho, JS Moon, KM Jude, D Fernandez, ...
Nature 603 (7900), 321-327, 2022
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