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guido van mierlo
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The complexity of PRC2 subcomplexes
G van Mierlo, GJC Veenstra, M Vermeulen, H Marks
Trends in cell biology 29 (8), 660-671, 2019
2002019
MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding
M Perino, G van Mierlo, ID Karemaker, S van Genesen, M Vermeulen, ...
Nature genetics 50 (7), 1002-1010, 2018
1752018
PRC2. 1 and PRC2. 2 synergize to coordinate H3K27 trimethylation
E Healy, M Mucha, E Glancy, DJ Fitzpatrick, E Conway, HK Neikes, ...
Molecular cell 76 (3), 437-452. e6, 2019
1572019
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
GL Brien, D Remillard, J Shi, ML Hemming, J Chabon, K Wynne, ...
Elife 7, e41305, 2018
1492018
Dynamics of gene silencing during X inactivation using allele-specific RNA-seq
H Marks, HHD Kerstens, TS Barakat, E Splinter, RAM Dirks, G van Mierlo, ...
Genome biology 16, 1-20, 2015
1282015
Integrative proteomic profiling reveals PRC2-dependent epigenetic crosstalk maintains ground-state pluripotency
G van Mierlo, RAM Dirks, L De Clerck, AB Brinkman, M Huth, SL Kloet, ...
Cell stem cell 24 (1), 123-137. e8, 2019
1022019
In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states
A Neagu, E van Genderen, I Escudero, L Verwegen, D Kurek, J Lehmann, ...
Nature cell biology 22 (5), 534-545, 2020
982020
Predicting protein condensate formation using machine learning
G van Mierlo, JRG Jansen, J Wang, I Poser, SJ van Heeringen, ...
Cell reports 34 (5), 2021
762021
Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader
GH van Muijlwijk, G van Mierlo, PWTC Jansen, M Vermeulen, ...
Gut Microbes 13 (1), 1966278, 2021
502021
Purification and enrichment of specific chromatin loci
M Gauchier, G van Mierlo, M Vermeulen, J Déjardin
Nature Methods 17 (4), 380-389, 2020
372020
Off-the-shelf proximity biotinylation for interaction proteomics
I Santos-Barriopedro, G van Mierlo, M Vermeulen
Nature communications 12 (1), 5015, 2021
362021
Two functional axes of feedback-enforced PRC2 recruitment in mouse embryonic stem cells
M Perino, G van Mierlo, C Loh, SMT Wardle, DW Zijlmans, H Marks, ...
Stem Cell Reports 15 (6), 1287-1300, 2020
29*2020
Critical role for P53 in regulating the cell cycle of ground state embryonic stem cells
M Ter Huurne, T Peng, G Yi, G van Mierlo, H Marks, HG Stunnenberg
Stem cell reports 14 (2), 175-183, 2020
272020
Chromatin proteomics to study epigenetics—challenges and opportunities
G van Mierlo, M Vermeulen
Molecular & Cellular Proteomics 20, 2021
252021
A mass spectrometry survey of chromatin‐associated proteins in pluripotency and early lineage commitment
G van Mierlo, RA Wester, H Marks
Proteomics 19 (14), 1900047, 2019
172019
Chromatin modules and their implication in genomic organization and gene regulation
G van Mierlo, O Pushkarev, JF Kribelbauer, B Deplancke
Trends in Genetics 39 (2), 140-153, 2023
122023
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation
JM Valverde, G Dubra, M Phillips, A Haider, C Elena-Real, A Fournet, ...
Nature Communications 14 (1), 6316, 2023
11*2023
Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states
RAM Dirks, G Van Mierlo, HHD Kerstens, AS Bernardo, J Kobolák, I Bock, ...
Epigenetics & Chromatin 12, 1-21, 2019
102019
Direct in vivo activation of T cells with nanosized immunofilaments inhibits tumor growth and metastasis
L Weiss, J Weiden, Y Dölen, EM Grad, EAW van Dinther, M Schluck, ...
Acs Nano 17 (13), 12101-12117, 2023
82023
Quantitative subcellular proteomics using SILAC reveals enhanced metabolic buffering in the pluripotent ground state
G van Mierlo, RA Wester, H Marks
Stem Cell Research 33, 135-145, 2018
82018
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