Richard Possemato
Richard Possemato
Associate Professor, NYU School of Medicine
Verified email at - Homepage
Cited by
Cited by
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
R Possemato, KM Marks, YD Shaul, ME Pacold, D Kim, K Birsoy, ...
Nature 476 (7360), 346-350, 2011
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
L Jackson-Grusby, C Beard, R Possemato, M Tudor, D Fambrough, ...
Nature genetics 27 (1), 31-39, 2001
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
K Birsoy, R Possemato, FK Lorbeer, EC Bayraktar, P Thiru, B Yucel, ...
Nature 508 (7494), 108-112, 2014
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
SW Alvarez, VO Sviderskiy, EM Terzi, T Papagiannakopoulos, AL Moreira, ...
Nature 551 (7682), 639-643, 2017
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
K Masutomi, R Possemato, JMY Wong, JL Currier, Z Tothova, JB Manola, ...
Proceedings of the national academy of sciences 102 (23), 8222-8227, 2005
A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
BC Grabiner, V Nardi, K Birsoy, R Possemato, K Shen, S Sinha, A Jordan, ...
Cancer discovery 4 (5), 554-563, 2014
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
Y Maida, M Yasukawa, M Furuuchi, T Lassmann, R Possemato, ...
Nature 461 (7261), 230-235, 2009
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ...
Nature chemical biology 12 (6), 452-458, 2016
Identification of specific PP2A complexes involved in human cell transformation
W Chen, R Possemato, KT Campbell, CA Plattner, DC Pallas, WC Hahn
Cancer cell 5 (2), 127-136, 2004
T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells
G Lugo-Villarino, R Maldonado-López, R Possemato, C Peñaranda, ...
Proceedings of the National Academy of Sciences 100 (13), 7749-7754, 2003
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
J Garcia-Bermudez, L Baudrier, K La, XG Zhu, J Fidelin, VO Sviderskiy, ...
Nature cell biology 20 (7), 775-781, 2018
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
D Kim, BP Fiske, K Birsoy, E Freinkman, K Kami, RL Possemato, ...
Nature 520 (7547), 363-367, 2015
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
K Birsoy, T Wang, R Possemato, OH Yilmaz, CE Koch, WW Chen, ...
Nature genetics 45 (1), 104-108, 2013
Store-operated Ca2+ entry controls clonal expansion of T cells through metabolic reprogramming
M Vaeth, M Maus, S Klein-Hessling, E Freinkman, J Yang, M Eckstein, ...
Immunity 47 (4), 664-679. e6, 2017
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
YD Shaul, E Freinkman, WC Comb, JR Cantor, WL Tam, P Thiru, D Kim, ...
Cell 158 (5), 1094-1109, 2014
Cancer-Associated PP2A A
W Chen, JD Arroyo, JC Timmons
Cancer Res 65, 8183-8192, 2005
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
VI Sayin, SE LeBoeuf, SX Singh, SM Davidson, D Biancur, BS Guzelhan, ...
Elife 6, e28083, 2017
Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAs
DR Minton, M Nam, DJ McLaughlin, J Shin, EC Bayraktar, SW Alvarez, ...
Molecular cell 69 (4), 610-621. e5, 2018
KRAS4A directly regulates hexokinase 1
CR Amendola, JP Mahaffey, SJ Parker, IM Ahearn, WC Chen, M Zhou, ...
Nature 576 (7787), 482-486, 2019
Amino acid management in cancer
ZY Tsun, R Possemato
Seminars in cell & developmental biology 43, 22-32, 2015
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