| Adenosine kinase and ribokinase–the RK family of proteins J Park, RS Gupta Cellular and molecular life sciences 65, 2875-2896, 2008 | 156 | 2008 |
| Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus XA Cui, B Singh, J Park, RS Gupta Biochemical and biophysical research communications 388 (1), 46-50, 2009 | 69 | 2009 |
| Human isoprenoid synthase enzymes as therapeutic targets J Park, AN Matralis, AM Berghuis, YS Tsantrizos Frontiers in chemistry 2, 50, 2014 | 60 | 2014 |
| Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells YS Lin, J Park, JW De Schutter, XF Huang, AM Berghuis, M Sebag, ... Journal of Medicinal Chemistry 55 (7), 3201-3215, 2012 | 57 | 2012 |
| Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition CY Leung, J Park, JW De Schutter, M Sebag, AM Berghuis, YS Tsantrizos Journal of medicinal chemistry 56 (20), 7939-7950, 2013 | 56 | 2013 |
| Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers DD Waller, J Park, YS Tsantrizos Critical reviews in biochemistry and molecular biology 54 (1), 41-60, 2019 | 55 | 2019 |
| Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase J Park, P van Koeverden, B Singh, RS Gupta FEBS letters 581 (17), 3211-3216, 2007 | 53 | 2007 |
| Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product J Park, M Zielinski, A Magder, YS Tsantrizos, AM Berghuis Nature communications 8 (1), 1-8, 2017 | 44 | 2017 |
| Unraveling the prenylation–cancer paradox in multiple myeloma with novel geranylgeranyl pyrophosphate synthase (GGPPS) inhibitors CM Lacbay, DD Waller, J Park, M Gómez Palou, F Vincent, XF Huang, ... Journal of medicinal chemistry 61 (15), 6904-6917, 2018 | 39 | 2018 |
| Adenosine metabolism, adenosine kinase, and evolution J Park, RS Gupta Adenosine, 23-54, 2013 | 39 | 2013 |
| Maintenance of native-like protein dynamics may not be required for engineering functional proteins SMC Gobeil, CM Clouthier, J Park, D Gagné, AM Berghuis, N Doucet, ... Chemistry & biology 21 (10), 1330-1340, 2014 | 37 | 2014 |
| Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases JW De Schutter, J Park, CY Leung, P Gormley, YS Lin, Z Hu, AM Berghuis, ... Journal of medicinal chemistry 57 (13), 5764-5776, 2014 | 37 | 2014 |
| Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme … J Park, YS Lin, JW De Schutter, YS Tsantrizos, AM Berghuis BMC Structural Biology 12, 1-12, 2012 | 30 | 2012 |
| Pharmacophore mapping of thienopyrimidine-based monophosphonate (ThP-MP) inhibitors of the human farnesyl pyrophosphate synthase J Park, CY Leung, AN Matralis, CM Lacbay, M Tsakos, ... Journal of Medicinal Chemistry 60 (5), 2119-2134, 2017 | 28 | 2017 |
| Phosphonate and bisphosphonate inhibitors of farnesyl pyrophosphate synthases: A structure-guided perspective J Park, VR Pandya, SJ Ezekiel, AM Berghuis Frontiers in Chemistry 8, 612728, 2021 | 27 | 2021 |
| Structural and functional insights into esterase-mediated macrolide resistance M Zieliński, J Park, B Sleno, AM Berghuis Nature communications 12 (1), 1732, 2021 | 25 | 2021 |
| A potential gain-of-function variant of SLC9A6 leads to endosomal alkalinization and neuronal atrophy associated with Christianson Syndrome A Ilie, AYL Gao, A Boucher, J Park, AM Berghuis, MJV Hoffer, ... Neurobiology of disease 121, 187-204, 2019 | 25 | 2019 |
| Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase D Gritzalis, J Park, W Chiu, H Cho, YS Lin, JW De Schutter, CM Lacbay, ... Bioorganic & medicinal chemistry letters 25 (5), 1117-1123, 2015 | 25 | 2015 |
| The structural dynamics of engineered β-lactamases vary broadly on three timescales yet sustain native function SMC Gobeil, MC Ebert, J Park, D Gagné, N Doucet, AM Berghuis, J Pleiss, ... Scientific reports 9 (1), 6656, 2019 | 22 | 2019 |
| Phosphorylated derivatives that activate or inhibit mammalian adenosine kinase provide insights into the role of pentavalent ions in AK catalysis J Park, B Singh, MC Maj, RS Gupta The Protein Journal 23, 167-177, 2004 | 15 | 2004 |
Albert M. BerghuisDistinguished James McGill Professor of Biochemistry, Microbiology & Immunology, McGill UniversityVerified email at mcgill.ca
