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David E. Root
David E. Root
Broad Institute
Verified email at broadinstitute.org
Title
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Cited by
Year
Genome-scale CRISPR-Cas9 knockout screening in human cells
O Shalem, NE Sanjana, E Hartenian, X Shi, DA Scott, TS Mikkelsen, ...
Science 343 (6166), 84-87, 2014
54792014
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ...
Nature biotechnology 34 (2), 184-191, 2016
37512016
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
DA Barbie, P Tamayo, JS Boehm, SY Kim, SE Moody, IF Dunn, ...
Nature 462 (7269), 108-112, 2009
30552009
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ...
Cell 171 (6), 1437-1452. e17, 2017
25322017
lincRNAs act in the circuitry controlling pluripotency and differentiation
M Guttman, J Donaghey, BW Carey, M Garber, JK Grenier, G Munson, ...
Nature 477 (7364), 295-300, 2011
21572011
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ...
Cell 124 (6), 1283-1298, 2006
20132006
Defining a cancer dependency map
A Tsherniak, F Vazquez, PG Montgomery, BA Weir, G Kryukov, ...
Cell 170 (3), 564-576. e16, 2017
20042017
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
JG Doench, E Hartenian, DB Graham, Z Tothova, M Hegde, I Smith, ...
Nature biotechnology 32 (12), 1262-1267, 2014
17412014
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
CM Johannessen, JS Boehm, SY Kim, SR Thomas, L Wardwell, ...
Nature 468 (7326), 968-972, 2010
17132010
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
R Possemato, KM Marks, YD Shaul, ME Pacold, D Kim, K Birsoy, ...
Nature 476 (7360), 346-350, 2011
16362011
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ...
Nature genetics 49 (12), 1779-1784, 2017
15212017
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
BL Ebert, J Pretz, J Bosco, CY Chang, P Tamayo, N Galili, A Raza, ...
Nature 451 (7176), 335-339, 2008
10812008
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
RT Manguso, HW Pope, MD Zimmer, FD Brown, KB Yates, BC Miller, ...
Nature 547 (7664), 413-418, 2017
9762017
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24 stem cell–like breast cancer cells in human tumors
LLC Marotta, V Almendro, A Marusyk, M Shipitsin, J Schemme, SR Walker, ...
The Journal of clinical investigation 121 (7), 2723-2735, 2011
9752011
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
J Rosenbluh, D Nijhawan, AG Cox, X Li, JT Neal, EJ Schafer, TI Zack, ...
Cell 151 (7), 1457-1473, 2012
8102012
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
R Firestein, AJ Bass, SY Kim, IF Dunn, SJ Silver, I Guney, E Freed, ...
Nature 455 (7212), 547-551, 2008
7932008
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy
J Barretina, BS Taylor, S Banerji, AH Ramos, M Lagos-Quintana, ...
Nature genetics 42 (8), 715-721, 2010
7862010
(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
JA Losman, RE Looper, P Koivunen, S Lee, RK Schneider, C McMahon, ...
Science 339 (6127), 1621-1625, 2013
7672013
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
SD Shapira, I Gat-Viks, BOV Shum, A Dricot, MM de Grace, L Wu, ...
Cell 139 (7), 1255-1267, 2009
7342009
KRAS and YAP1 converge to regulate EMT and tumor survival
DD Shao, W Xue, EB Krall, A Bhutkar, F Piccioni, X Wang, AC Schinzel, ...
Cell 158 (1), 171-184, 2014
7332014
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