High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease K Parey, O Haapanen, V Sharma, H Köfeler, T Züllig, S Prinz, K Siegmund, ... Science Advances 5 (12), eaax9484, 2019 | 131 | 2019 |
Redox-coupled quinone dynamics in the respiratory complex I J Warnau, V Sharma, AP Gamiz-Hernandez, A Di Luca, O Haapanen, ... Proceedings of the National Academy of Sciences 115 (36), E8413-E8420, 2018 | 92 | 2018 |
High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism K Parey, J Lasham, DJ Mills, A Djurabekova, O Haapanen, EG Yoga, ... Science advances 7 (46), eabj3221, 2021 | 67 | 2021 |
Role of water and protein dynamics in proton pumping by respiratory complex I O Haapanen, V Sharma Scientific reports 7 (1), 1-12, 2017 | 60 | 2017 |
Structural basis of mitochondrial membrane bending by the I–II–III2–IV2 supercomplex A Mühleip, RK Flygaard, R Baradaran, O Haapanen, T Gruhl, ... Nature, 1-5, 2023 | 52 | 2023 |
Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I O Haapanen, A Djurabekova, V Sharma Frontiers in chemistry 7, 221, 2019 | 46 | 2019 |
A modeling and simulation perspective on the mechanism and function of respiratory complex I O Haapanen, V Sharma Biochimica et Biophysica Acta (BBA)-Bioenergetics 1859 (7), 510-523, 2018 | 37 | 2018 |
Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics EG Yoga, O Haapanen, I Wittig, K Siegmund, V Sharma, V Zickermann Biochimica et Biophysica Acta (BBA)-Bioenergetics 1860 (7), 573-581, 2019 | 36 | 2019 |
Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I E Galemou Yoga, K Parey, A Djurabekova, O Haapanen, K Siegmund, ... Nature communications 11 (1), 1-8, 2020 | 33 | 2020 |
Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I S Uno, T Masuya, K Shinzawa-Itoh, J Lasham, O Haapanen, T Shiba, ... Journal of Biological Chemistry 295 (8), 2449-2463, 2020 | 23 | 2020 |
Coupling of quinone dynamics to proton pumping in respiratory complex I O Haapanen, M Reidelbach, V Sharma Biochimica et Biophysica Acta (BBA)-Bioenergetics 1861 (12), 148287, 2020 | 20 | 2020 |
Redox-and protonation-state driven substrate-protein dynamics in respiratory complex I O Haapanen, V Sharma Current opinion in electrochemistry 29, 100741, 2021 | 17 | 2021 |
Proton motive function of the terminal antiporter-like subunit in respiratory complex I A Djurabekova, O Haapanen, V Sharma Biochimica et Biophysica Acta (BBA)-Bioenergetics 1861 (7), 148185, 2020 | 13 | 2020 |
Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations Y Lee, O Haapanen, A Altmeyer, W Kühlbrandt, V Sharma, V Zickermann Nature Communications 13 (1), 6091, 2022 | 10 | 2022 |
Atomistic Molecular Dynamics Simulations of Mitochondrial DNA Polymerase γ: Novel Mechanisms of Function and Pathogenesis L Euro, O Haapanen, T Róg, I Vattulainen, A Suomalainen, V Sharma Biochemistry 56 (9), 1227-1238, 2017 | 7 | 2017 |
Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I J Lasham, O Haapanen, V Zickermann, V Sharma Biochimica et Biophysica Acta (BBA)-Bioenergetics, 148951, 2022 | 5 | 2022 |
Docking and molecular simulations reveal a quinone‐binding site on the surface of respiratory complex I A Djurabekova, E Galemou Yoga, A Nyman, A Pirttikoski, V Zickermann, ... FEBS letters 596 (9), 1133-1146, 2022 | 5 | 2022 |
Targeting respiratory complex I—molecular mechanism and drug design V Sharma, J Lasham, O Haapanen Clinical Bioenergetics, 327-340, 2021 | 1 | 2021 |
Proton translocation channels in respiratory complex I probed by molecular dynamics simulations O Haapanen | 1 | 2017 |
Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A Y Liu, ODC Ribeiro, O Haapanen, GB Craven, V Sharma, SP Muench, ... Journal of Biological Chemistry 298 (10), 2022 | | 2022 |