| Perilous journey: a tour of the ubiquitin–proteasome system G Kleiger, T Mayor Trends in cell biology 24 (6), 352-359, 2014 | 382 | 2014 |
| Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding BS Cobb, S Morales-Alcelay, G Kleiger, KE Brown, AG Fisher, ST Smale Genes & development 14 (17), 2146-2160, 2000 | 309 | 2000 |
| GXXXG and AXXXA: common α-helical interaction motifs in proteins, particularly in extremophiles G Kleiger, R Grothe, P Mallick, D Eisenberg Biochemistry 41 (19), 5990-5997, 2002 | 258 | 2002 |
| Detection of sequential polyubiquitylation on a millisecond timescale NW Pierce, G Kleiger, S Shan, RJ Deshaies Nature 462 (7273), 615-619, 2009 | 237 | 2009 |
| GXXXG and GXXXA motifs stabilize FAD and NAD (P)-binding Rossmann folds through Cα–H⋯ O hydrogen bonds and van der Waals interactions G Kleiger, D Eisenberg Journal of molecular biology 323 (1), 69-76, 2002 | 220 | 2002 |
| Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates G Kleiger, A Saha, S Lewis, B Kuhlman, RJ Deshaies Cell 139 (5), 957-968, 2009 | 211 | 2009 |
| NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly K Baek, DT Krist, JR Prabu, S Hill, M Klügel, LM Neumaier, S von Gronau, ... Nature 578 (7795), 461-466, 2020 | 193 | 2020 |
| Selective dimerization of a C2H2 zinc finger subfamily AS McCarty, G Kleiger, D Eisenberg, ST Smale Molecular cell 11 (2), 459-470, 2003 | 160 | 2003 |
| Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate A Saha, S Lewis, G Kleiger, B Kuhlman, RJ Deshaies Molecular cell 42 (1), 75-83, 2011 | 127 | 2011 |
| Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly D Horn-Ghetko, DT Krist, JR Prabu, K Baek, MPC Mulder, M Klügel, ... Nature 590 (7847), 671-676, 2021 | 100 | 2021 |
| E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin H Huang, DF Ceccarelli, S Orlicky, DJ St-Cyr, A Ziemba, P Garg, ... Nature chemical biology 10 (2), 156-163, 2014 | 93 | 2014 |
| NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway W Den Besten, R Verma, G Kleiger, RS Oania, RJ Deshaies Nature structural & molecular biology 19 (5), 511-516, 2012 | 81 | 2012 |
| The 1.7 Å crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold G Kleiger, LJ Beamer, R Grothe, P Mallick, D Eisenberg Journal of molecular biology 299 (4), 1019-1034, 2000 | 58 | 2000 |
| Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways S Hill, K Reichermeier, DC Scott, L Samentar, J Coulombe-Huntington, ... Elife 8, e51163, 2019 | 38 | 2019 |
| The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4 G Kleiger, B Hao, DA Mohl, RJ Deshaies Journal of biological chemistry 284 (52), 36012-36023, 2009 | 34 | 2009 |
| Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex MD Petroski, G Kleiger, RJ Deshaies Molecular cell 24 (4), 523-534, 2006 | 27 | 2006 |
| Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler J Liwocha, DT Krist, GJ van der Heden van Noort, FM Hansen, VH Truong, ... Nature chemical biology 17 (3), 272-279, 2021 | 26 | 2021 |
| Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations D Sandoval, S Hill, A Ziemba, S Lewis, B Kuhlman, G Kleiger Journal of Biological Chemistry 290 (2), 1106-1118, 2015 | 23 | 2015 |
| Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins A Tyrrell, K Flick, G Kleiger, H Zhang, RJ Deshaies, P Kaiser Proceedings of the National Academy of Sciences 107 (46), 19796-19801, 2010 | 23 | 2010 |
| 3D structure and significance of the GΦXXG helix packing motif in tetramers of the E1β subunit of pyruvate dehydrogenase from the Archeon Pyrobaculum aerophilum G Kleiger, J Perry, D Eisenberg Biochemistry 40 (48), 14484-14492, 2001 | 23 | 2001 |
