Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay N Parker, MJ Turk, E Westrick, JD Lewis, PS Low, CP Leamon Analytical biochemistry 338 (2), 284-293, 2005 | 1406 | 2005 |
Synthesis and biological evaluation of EC20: a new folate-derived, 99mTc-based radiopharmaceutical CP Leamon, MA Parker, IR Vlahov, LC Xu, JA Reddy, M Vetzel, ... Bioconjugate chemistry 13 (6), 1200-1210, 2002 | 334 | 2002 |
Preclinical evaluation of 99mTc-EC20 for imaging folate receptor–positive tumors JA Reddy, LC Xu, N Parker, M Vetzel, CP Leamon Journal of Nuclear Medicine 45 (5), 857-866, 2004 | 156 | 2004 |
Synthesis and biological evaluation of EC72: a new folate-targeted chemotherapeutic CP Leamon, JA Reddy, IR Vlahov, M Vetzel, N Parker, JS Nicoson, LC Xu, ... Bioconjugate chemistry 16 (4), 803-811, 2005 | 139 | 2005 |
Comparative preclinical activity of the folate‐targeted Vinca alkaloid conjugates EC140 and EC145 CP Leamon, JA Reddy, IR Vlahov, E Westrick, N Parker, JS Nicoson, ... International journal of cancer 121 (7), 1585-1592, 2007 | 126 | 2007 |
Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue CP Leamon, JA Reddy, M Vetzel, R Dorton, E Westrick, N Parker, Y Wang, ... Cancer research 68 (23), 9839-9844, 2008 | 123 | 2008 |
In vivo structural activity and optimization studies of folate− tubulysin conjugates JA Reddy, R Dorton, A Dawson, M Vetzel, N Parker, JS Nicoson, ... Molecular pharmaceutics 6 (5), 1518-1525, 2009 | 90 | 2009 |
Impact of high and low folate diets on tissue folate receptor levels and antitumor responses toward folate-drug conjugates CP Leamon, JA Reddy, R Dorton, A Bloomfield, K Emsweller, N Parker, ... Journal of Pharmacology and Experimental Therapeutics 327 (3), 918-925, 2008 | 82 | 2008 |
Targeting Folate Receptors to Treat Invasive Urinary Bladder Cancer D Dhawan, JA Ramos-Vara, JF Naughton, L Cheng, PS Low, ... Cancer Research, 2012 | 70 | 2012 |
Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications CP Leamon, JA Reddy, PJ Klein, IR Vlahov, R Dorton, A Bloomfield, ... Journal of Pharmacology and Experimental Therapeutics 336 (2), 336-343, 2011 | 62 | 2011 |
Preclinical evaluation of bispecific adaptor molecule controlled folate receptor CAR-T cell therapy with special focus on pediatric malignancies YJ Lu, H Chu, LW Wheeler, M Nelson, E Westrick, JF Matthaei, II Cardle, ... Frontiers in oncology 9, 151, 2019 | 51 | 2019 |
Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate–targeted immunotherapy in hapten-immunized mice Y Lu, LC Xu, N Parker, E Westrick, JA Reddy, M Vetzel, PS Low, ... Molecular cancer therapeutics 5 (12), 3258-3267, 2006 | 46 | 2006 |
Methods For Treating Cancer Using Combination Therapies NL Parker, CP Leamon, IR Vlahov US Patent App. 13/803,392, 2014 | 33 | 2014 |
Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease KR Kipp, SL Kruger, MF Schimmel, N Parker, JM Shillingford, CP Leamon, ... American Journal of Physiology-Renal Physiology 315 (2), F395-F405, 2018 | 32 | 2018 |
Antiinflammatory activity of a novel folic acid targeted conjugate of the mTOR inhibitor everolimus Y Lu, N Parker, PJ Kleindl, VA Cross, K Wollak, E Westrick, TW Stinnette, ... Molecular Medicine 21, 584-596, 2015 | 22 | 2015 |
Detecting functional and accessible folate receptor expression in cancer and polycystic kidneys H Chu, JM Shillingford, JA Reddy, E Westrick, M Nelson, EZ Wang, ... Molecular Pharmaceutics 16 (9), 3985-3995, 2019 | 7 | 2019 |
Combinatorial strategies of folate receptor-targeted chemotherapy guided by improved understanding of tumor microenvironment and immunomodulation Y Lu, LW Wheeler, VA Cross, EM Westrick, AM Lloyd, TP Johnson, ... Cancer Research 77 (13_Supplement), 4574-4574, 2017 | 2 | 2017 |
Tc-99m-EC20-A novel folate-derived radiopharmaceutical for cancer diagnostic imaging. LC Xu, CP Leamon, MA Parker, IR Vlahov, JA Reddy, M Vetzel, ... Journal of Nuclear Medicine 43 (5), 367P-367P, 2002 | 1 | 2002 |
Methods for treating cancer using combination therapies NL Parker, CP Leamon, IR Vlahov US Patent 10,010,618, 2018 | | 2018 |
Treatment of epithelial ovarian cancer with folate receptor (α/β) targeted chemotherapy is enhanced by CTLA-4 blockade: Learning from animal models Y Lu, TP Johnson, LW Wheeler, AM Lloyd, VA Cross, EM Westrick, ... Cancer Research 77 (13_Supplement), 3670-3670, 2017 | | 2017 |