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David Snead
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TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
BS Johnson, D Snead, JJ Lee, JM McCaffery, J Shorter, AD Gitler
Journal of Biological Chemistry 284 (30), 20329-20339, 2009
8442009
Alpha-synuclein function and dysfunction on cellular membranes
D Snead, D Eliezer
Experimental neurobiology 23 (4), 292, 2014
2432014
Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction
CK Deniston, J Salogiannis, S Mathea, DM Snead, I Lahiri, ...
Nature 588 (7837), 344-349, 2020
1702020
Motor mechanism for protein threading through Hsp104
P Wendler, J Shorter, D Snead, C Plisson, DK Clare, S Lindquist, ...
Molecular cell 34 (1), 81-92, 2009
1122009
Synaptic vesicles position complexin to block spontaneous fusion
RT Wragg, D Snead, Y Dong, TF Ramlall, I Menon, J Bai, D Eliezer, ...
Neuron 77 (2), 323-334, 2013
892013
Membrane curvature sensing by the C-terminal domain of complexin
D Snead, RT Wragg, JS Dittman, D Eliezer
Nature communications 5 (1), 4955, 2014
762014
Intrinsically disordered proteins in synaptic vesicle trafficking and release
D Snead, D Eliezer
Journal of Biological Chemistry 294 (10), 3325-3342, 2019
632019
Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation
ME DeSantis, EA Sweeny, D Snead, EH Leung, MS Go, K Gupta, ...
Journal of Biological Chemistry 289 (2), 848-867, 2014
532014
Probing structural transitions in the intrinsically disordered C-terminal domain of the measles virus nucleoprotein by vibrational spectroscopy of cyanylated cysteines
CG Bischak, S Longhi, DM Snead, S Costanzo, E Terrer, CH Londergan
Biophysical journal 99 (5), 1676-1683, 2010
492010
The accessory helix of complexin functions by stabilizing central helix secondary structure
DT Radoff, Y Dong, D Snead, J Bai, D Eliezer, JS Dittman
Elife 3, e04553, 2014
412014
Unique structural features of membrane-bound C-terminal domain motifs modulate complexin inhibitory function
D Snead, AL Lai, RT Wragg, DA Parisotto, TF Ramlall, JS Dittman, ...
Frontiers in molecular neuroscience 10, 154, 2017
322017
Evolutionary divergence of the c-terminal domain of complexin accounts for functional disparities between vertebrate and invertebrate complexins
RT Wragg, DA Parisotto, Z Li, MS Terakawa, D Snead, I Basu, ...
Frontiers in molecular neuroscience 10, 146, 2017
282017
Dynamic asymmetry and the role of the conserved active-site thiol in rabbit muscle creatine kinase
CH Londergan, R Baskin, CG Bischak, KW Hoffman, DM Snead, ...
Biochemistry 54 (1), 83-95, 2015
182015
Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
DM Snead, M Matyszewski, AM Dickey, YX Lin, AE Leschziner, ...
Nature Structural & Molecular Biology 29 (12), 1196-1207, 2022
172022
Parkinson’s Disease-linked LRRK2 structure and model for microtubule interaction
C Deniston
University of California, San Diego, 2020
122020
The role of membrane affinity and binding modes in alpha-synuclein regulation of vesicle release and trafficking
T Das, M Ramezani, D Snead, C Follmer, P Chung, KY Lee, DA Holowka, ...
Biomolecules 12 (12), 1816, 2022
42022
Spectroscopic characterization of structure–function relationships in the intrinsically disordered protein complexin
D Snead, D Eliezer
Methods in enzymology 611, 227-286, 2018
32018
Erratum: TDP-43 intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity (Journal of Biological …
BS Johnson, D Snead, JJ Lee, JM McCaffery, J Shorter, AD Gitler
Journal of Biological Chemistry 284 (37), 25459, 2009
12009
LRRK2 cloning, plasmid construction, and mutagenesis
D Snead, YX Lin
2023
LRRK2RCKW Widefield fluorescence microtubule binding assay
DM Snead
2022
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Articles 1–20