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Vijayan Ramaswamy
Vijayan Ramaswamy
University of Texas, MD Anderson Cancer Center
Bestätigte E-Mail-Adresse bei mdanderson.org
Titel
Zitiert von
Zitiert von
Jahr
Structure-based classification predicts drug response in EGFR-mutant NSCLC
JP Robichaux, X Le, RSK Vijayan, JK Hicks, S Heeke, YY Elamin, HY Lin, ...
Nature 597 (7878), 732-737, 2021
2322021
Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors.
RSK Vijayan, P He, V Modi, Duong-Ly KC, H Ma, JR Peterson, D RL Jr, ...
J Med Chem, 2014
2072014
Pan-cancer landscape and analysis of ERBB2 mutations identifies poziotinib as a clinically active inhibitor and enhancer of T-DM1 activity
JP Robichaux, YY Elamin, RSK Vijayan, MB Nilsson, L Hu, J He, F Zhang, ...
Cancer Cell 36 (4), 444-457. e7, 2019
1572019
Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors
JD Bauman, D Patel, SF Baker, RSK Vijayan, A Xiang, AK Parhi, ...
ACS chemical biology 8 (11), 2501-2508, 2013
942013
Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening
JD Bauman, D Patel, C Dharia, M Fromer, S Ahmed, Y Frenkel, ...
Journal of Medicinal Chemistry, 2013
902013
Enhancing preclinical drug discovery with artificial intelligence
RSK Vijayan, J Kihlberg, JB Cross, V Poongavanam
Drug discovery today 27 (4), 967-984, 2022
692022
Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease
N Deng, S Forli, P He, A Perryman, L Wickstrom, RSK Vijayan, ...
The Journal of Physical Chemistry B 119 (3), 976-988, 2015
662015
3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease
HY Sagong, A Parhi, JD Bauman, D Patel, RSK Vijayan, K Das, E Arnold, ...
ACS medicinal chemistry letters 4 (6), 547-550, 2013
612013
Structural propensities of kinase family proteins from a Potts model of residue co‐variation
A Haldane, WF Flynn, P He, RSK Vijayan, RM Levy
Protein Science 25 (8), 1378-1384, 2016
592016
Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity
YY Elamin, JP Robichaux, BW Carter, M Altan, H Tran, DL Gibbons, ...
Cancer Cell 40 (7), 754-767. e6, 2022
482022
Rationalizing fragment based drug discovery for BACE1: insights from FB-QSAR, FB-QSSR, multi objective (MO-QSPR) and MIF studies
P Manoharan, RSK Vijayan, N Ghoshal
Journal of Computer-Aided Molecular Design 24, 843-864, 2010
462010
Phenyl substituted 3-hydroxypyridin-2 (1H)-ones: inhibitors of influenza A endonuclease
AK Parhi, A Xiang, JD Bauman, D Patel, RSK Vijayan, K Das, E Arnold, ...
Bioorganic & medicinal chemistry 21 (21), 6435-6446, 2013
422013
Hybrid structure-based virtual screening protocol for the identification of novel BACE1 inhibitors
RSK Vijayan, M Prabu, NM Mascarenhas, N Ghoshal
Journal of chemical information and modeling 49 (3), 647-657, 2009
282009
Discovery of Safe and Orally Effective 4-Aminoquinaldine Analogues as Apoptotic Inducers with Activity against Experimental Visceral Leishmaniasis
P Palit, A Hazra, A Maity, RSK Vijayan, P Manoharan, S Banerjee, ...
Antimicrobial Agents and Chemotherapy 56 (1), 432-445, 2012
232012
Combinatorial library enumeration and lead hopping using comparative interaction fingerprint analysis and classical 2D QSAR methods for seeking novel GABAA α3 modulators
RSK Vijayan, I Bera, M Prabu, S Saha, N Ghoshal
Journal of chemical information and modeling 49 (11), 2498-2511, 2009
232009
Large scale free energy calculations for blind predictions of protein–ligand binding: the D3R Grand Challenge 2015
N Deng, WF Flynn, J Xia, RSK Vijayan, B Zhang, P He, A Mentes, ...
Journal of computer-aided molecular design 30, 743-751, 2016
202016
Molecular dynamics study of HIV‐1 RT‐DNA‐nevirapine complexes explains NNRTI inhibition and resistance by connection mutations
RSK Vijayan, E Arnold, K Das
Proteins: Structure, Function, and Bioinformatics 82 (5), 815-829, 2014
202014
Crystal structures of an archaeal thymidylate kinase from Sulfolobus tokodaii provide insights into the role of a conserved active site Arginine residue
A Biswas, A Shukla, RSK Vijayan, J Jeyakanthan, K Sekar
Journal of Structural Biology 197 (3), 236-249, 2017
152017
Modeling the Closed and Open State Conformations of the GABAA Ion Channel - Plausible Structural Insights for Channel Gating
RSK Vijayan, N Trivedi, SN Roy, I Bera, P Manoharan, PV Payghan, ...
Journal of chemical information and modeling 52 (11), 2958-2969, 2012
152012
Structural basis for ligand recognition at the benzodiazepine binding site of GABAA α3 receptor, and pharmacophore-based virtual screening approach
RSK Vijayan, N Ghoshal
Journal of Molecular Graphics and Modelling 27 (3), 286-298, 2008
142008
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