| Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR) CE Bear, C Li, N Kartner, RJ Bridges, TJ Jensen, M Ramjeesingh, ... Cell 68 (4), 809-818, 1992 | 1189 | 1992 |
| Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance N Kartner, JW Hanrahan, TJ Jensen, AL Naismith, S Sun, CA Ackerley, ... Cell 64 (4), 681-691, 1991 | 609 | 1991 |
| Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor R Rozmahe, M Wilschanski, A Matin, S Plyte, M Oliver, W Auerbach, ... Nature genetics 12 (3), 280-287, 1996 | 487 | 1996 |
| The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on … GL Lukacs, XB Chang, C Bear, N Kartner, A Mohamed, JR Riordan, ... Journal of Biological Chemistry 268 (29), 21592-21598, 1993 | 472 | 1993 |
| Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein AP Wong, CE Bear, S Chin, P Pasceri, TO Thompson, LJ Huan, F Ratjen, ... Nature biotechnology 30 (9), 876-882, 2012 | 465 | 2012 |
| Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP … PDW Eckford, C Li, M Ramjeesingh, CE Bear Journal of Biological Chemistry 287 (44), 36639-36649, 2012 | 343 | 2012 |
| ATPase activity of the cystic fibrosis transmembrane conductance regulator C Li, M Ramjeesingh, W Wang, E Garami, M Hewryk, D Lee, ... Journal of Biological Chemistry 271 (45), 28463-28468, 1996 | 335 | 1996 |
| Directed differentiation of cholangiocytes from human pluripotent stem cells M Ogawa, S Ogawa, CE Bear, S Ahmadi, S Chin, B Li, M Grompe, ... Nature biotechnology 33 (8), 853-861, 2015 | 305 | 2015 |
| CFTR directly mediates nucleotide-regulated glutathione flux I Kogan, M Ramjeesingh, C Li, JF Kidd, Y Wang, EM Leslie, SPC Cole, ... The EMBO journal 22 (9), 1981-1989, 2003 | 268 | 2003 |
| Cl-channel activity in Xenopus oocytes expressing the cystic fibrosis gene. CE Bear, F Duguay, AL Naismith, N Kartner, JW Hanrahan, JR Riordan Journal of Biological Chemistry 266 (29), 19142-19145, 1991 | 256 | 1991 |
| The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR C Li, M Ramjeesingh, E Reyes, T Jensen, X Chang, JM Rommens, ... Nature genetics 3 (4), 311-316, 1993 | 220 | 1993 |
| Lung disease in mice with cystic fibrosis. G Kent, R Iles, CE Bear, LJ Huan, U Griesenbach, C McKerlie, H Frndova, ... The Journal of clinical investigation 100 (12), 3060-3069, 1997 | 213 | 1997 |
| Novel method for evaluation of the oligomeric structure of membrane proteins M RAMJEESINGH, LJ HUAN, E GARAMI, CE BEAR Biochemical Journal 342 (1), 119-123, 1999 | 170 | 1999 |
| A nonselective cation channel in rat liver cells is activated by membrane stretch CE Bear American Journal of Physiology-Cell Physiology 258 (3), C421-C428, 1990 | 146 | 1990 |
| Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator) M Ramjeesingh, C Li, E Garami, LJ Huan, K Galley, Y Wang, CE Bear Biochemistry 38 (5), 1463-1468, 1999 | 141 | 1999 |
| cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator. JM Rommens, S Dho, CE Bear, N Kartner, D Kennedy, JR Riordan, ... Proceedings of the National Academy of Sciences 88 (17), 7500-7504, 1991 | 139 | 1991 |
| Purified Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Does Not Function as an ATP Channel (∗) C Li, M Ramjeesingh, CE Bear Journal of Biological Chemistry 271 (20), 11623-11626, 1996 | 136 | 1996 |
| The chloride channel ClC-4 contributes to endosomal acidification and trafficking R Mohammad-Panah, R Harrison, S Dhani, C Ackerley, LJ Huan, Y Wang, ... Journal of Biological Chemistry 278 (31), 29267-29277, 2003 | 132 | 2003 |
| Cystic fibrosis transmembrane conductance regulator in human muscle: dysfunction causes abnormal metabolic recovery in exercise AM Lamhonwah, CE Bear, LJ Huan, PK Chiaw, CA Ackerley, I Tein Annals of neurology 67 (6), 802-808, 2010 | 127 | 2010 |
| Rescue of multiple class II CFTR mutations by elexacaftor+ tezacaftor+ ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator O Laselva, C Bartlett, TNA Gunawardena, H Ouyang, PDW Eckford, ... European Respiratory Journal 57 (6), 2021 | 122 | 2021 |
