| Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists LA Solt, Y Wang, S Banerjee, T Hughes, DJ Kojetin, T Lundasen, Y Shin, ... Nature 485 (7396), 62-68, 2012 | 777 | 2012 |
| Evidence that opioids may have toll-like receptor 4 and MD-2 effects MR Hutchinson, Y Zhang, M Shridhar, JH Evans, MM Buchanan, TX Zhao, ... Brain, behavior, and immunity 24 (1), 83-95, 2010 | 567 | 2010 |
| Nuclear receptors and their selective pharmacologic modulators TP Burris, LA Solt, Y Wang, C Crumbley, S Banerjee, K Griffett, ... Pharmacological reviews 65 (2), 710-778, 2013 | 285 | 2013 |
| Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain ED Milligan, EM Sloane, SJ Langer, TS Hughes, BM Jekich, MG Frank, ... Pain 126 (1-3), 294-308, 2006 | 196 | 2006 |
| An alternate binding site for PPARγ ligands TS Hughes, PK Giri, IMS De Vera, DP Marciano, DS Kuruvilla, Y Shin, ... Nature communications 5 (1), 3571, 2014 | 182 | 2014 |
| Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism TS Hughes, MJ Chalmers, S Novick, DS Kuruvilla, MR Chang, ... Structure 20 (1), 139-150, 2012 | 169 | 2012 |
| Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network JC Nwachukwu, S Srinivasan, NE Bruno, AA Parent, TS Hughes, ... elife 3, e02057, 2014 | 142 | 2014 |
| Intrathecal polymer-based interleukin-10* gene delivery for neuropathic pain ED Milligan, RG Soderquist, SM Malone, JH Mahoney, TS Hughes, ... Neuron glia biology 2 (4), 293-308, 2006 | 133 | 2006 |
| Structural mechanism for signal transduction in RXR nuclear receptor heterodimers DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ... Nature communications 6 (1), 8013, 2015 | 132 | 2015 |
| Pharmacological repression of PPARγ promotes osteogenesis DP Marciano, DS Kuruvilla, SV Boregowda, A Asteian, TS Hughes, ... Nature communications 6 (1), 7443, 2015 | 118 | 2015 |
| Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ J Shang, R Brust, SA Mosure, J Bass, P Munoz-Tello, H Lin, TS Hughes, ... Elife 7, e43320, 2018 | 66 | 2018 |
| Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α S Srinivasan, JC Nwachukwu, AA Parent, V Cavett, J Nowak, TS Hughes, ... Nature chemical biology 9 (5), 326-332, 2013 | 66 | 2013 |
| Defining a conformational ensemble that directs activation of PPARγ IM Chrisman, MD Nemetchek, IMS De Vera, J Shang, Z Heidari, Y Long, ... Nature communications 9 (1), 1794, 2018 | 61 | 2018 |
| PEGylation of brain‐derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution RG Soderquist, ED Milligan, EM Sloane, JA Harrison, KK Douvas, ... Journal of Biomedical Materials Research Part A: An Official Journal of The …, 2009 | 59 | 2009 |
| A structural mechanism for directing corepressor-selective inverse agonism of PPARγ R Brust, J Shang, J Fuhrmann, SA Mosure, J Bass, A Cano, Z Heidari, ... Nature communications 9 (1), 4687, 2018 | 53 | 2018 |
| Synergistic regulation of coregulator/nuclear receptor interaction by ligand and DNA IMS de Vera, J Zheng, S Novick, J Shang, TS Hughes, R Brust, ... Structure 25 (10), 1506-1518. e4, 2017 | 51 | 2017 |
| Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1 IMS de Vera, P Munoz-Tello, J Zheng, V Dharmarajan, DP Marciano, ... Structure 27 (1), 66-77. e5, 2019 | 43 | 2019 |
| Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain E Sloane, S Langer, B Jekich, J Mahoney, T Hughes, M Frank, W Seibert, ... Gene therapy 16 (10), 1210-1222, 2009 | 42 | 2009 |
| Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins TS Hughes, SJ Langer, KW Johnson, RA Chavez, LR Watkins, ... Molecular Therapy 17 (1), 88-94, 2009 | 35 | 2009 |
| Structure of REV-ERBβ ligand-binding domain bound to a porphyrin antagonist E Matta-Camacho, S Banerjee, TS Hughes, LA Solt, Y Wang, TP Burris, ... Journal of Biological Chemistry 289 (29), 20054-20066, 2014 | 32 | 2014 |
