Charles Glabe
Charles Glabe
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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
R Kayed, E Head, JL Thompson, TM McIntire, SC Milton, CW Cotman, ...
Science 300 (5618), 486-489, 2003
A specific amyloid-β protein assembly in the brain impairs memory
S Lesné, MT Koh, L Kotilinek, R Kayed, CG Glabe, A Yang, M Gallagher, ...
Nature 440 (7082), 352-357, 2006
Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo
F Yang, GP Lim, AN Begum, OJ Ubeda, MR Simmons, SS Ambegaokar, ...
Journal of Biological Chemistry 280 (7), 5892-5901, 2005
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
CJ Pike, D Burdick, AJ Walencewicz, CG Glabe, CW Cotman
Journal of Neuroscience 13 (4), 1676-1687, 1993
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
D Burdick, B Soreghan, M Kwon, J Kosmoski, M Knauer, A Henschen, ...
Journal of Biological Chemistry 267 (1), 546-554, 1992
Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦
A Demuro, E Mina, R Kayed, SC Milton, I Parker, CG Glabe
Journal of Biological Chemistry 280 (17), 17294-17300, 2005
In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity
CJ Pike, AJ Walencewicz, CG Glabe, CW Cotman
Brain research 563 (1-2), 311-314, 1991
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases
R Kayed, Y Sokolov, B Edmonds, TM McIntire, SC Milton, JE Hall, ...
Journal of Biological Chemistry 279 (45), 46363-46366, 2004
Cu (II) potentiation of Alzheimer Aβ neurotoxicity: correlation with cell-free hydrogen peroxide production and metal reduction
X Huang, MP Cuajungco, CS Atwood, MA Hartshorn, JDA Tyndall, ...
Journal of Biological Chemistry 274 (52), 37111-37116, 1999
Structural classification of toxic amyloid oligomers
CG Glabe
Journal of Biological Chemistry 283 (44), 29639-29643, 2008
Structure‐activity analyses of β‐amyloid peptides: contributions of the β25–35 region to aggregation and neurotoxicity
CJ Pike, AJ Walencewicz‐Wasserman, J Kosmoski, DH Cribbs, CG Glabe, ...
Journal of neurochemistry 64 (1), 253-265, 1995
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
R Kayed, E Head, F Sarsoza, T Saing, CW Cotman, M Necula, L Margol, ...
Molecular neurodegeneration 2, 1-11, 2007
Small molecule inhibitors of aggregation indicate that amyloid β oligomerization and fibrillization pathways are independent and distinct
M Necula, R Kayed, S Milton, CG Glabe
Journal of Biological Chemistry 282 (14), 10311-10324, 2007
Atomic-resolution structure of a disease-relevant Aβ (1–42) amyloid fibril
MA Wälti, F Ravotti, H Arai, CG Glabe, JS Wall, A Böckmann, P Güntert, ...
Proceedings of the National Academy of Sciences 113 (34), E4976-E4984, 2016
Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
CG Glabe
Neurobiology of aging 27 (4), 570-575, 2006
Different conformations of amyloid β induce neurotoxicity by distinct mechanisms in human cortical neurons
A Deshpande, E Mina, C Glabe, J Busciglio
Journal of Neuroscience 26 (22), 6011-6018, 2006
Atomic view of a toxic amyloid small oligomer
A Laganowsky, C Liu, MR Sawaya, JP Whitelegge, J Park, M Zhao, ...
Science 335 (6073), 1228-1231, 2012
A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss
RM Cohen, K Rezai-Zadeh, TM Weitz, A Rentsendorj, D Gate, I Spivak, ...
Journal of Neuroscience 33 (15), 6245-6256, 2013
Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: a link between Aβ and tau pathology
S Oddo, A Caccamo, L Tran, MP Lambert, CG Glabe, WL Klein, ...
Journal of Biological Chemistry 281 (3), 1599-1604, 2006
Biosynthetic site-specific incorporation of a non-natural amino acid into a polypeptide
JD Bain, ES Diala, CG Glabe, TA Dix, AR Chamberlin
Journal of the American Chemical Society 111 (20), 8013-8014, 1989
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