| Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials E Liu, ME Schmidt, R Margolin, R Sperling, R Koeppe, NS Mason, ... Neurology 85 (8), 692-700, 2015 | 164 | 2015 |
| Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity R Angell, NM Aston, P Bamborough, JB Buckton, S Cockerill, SJ deboeck, ... Bioorganic & medicinal chemistry letters 18 (15), 4428-4432, 2008 | 83 | 2008 |
| Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the first workshop on drug transporters in the lungs C Ehrhardt, P Bäckman, W Couet, C Edwards, B Forbes, M Fridén, ... Journal of Pharmaceutical Sciences 106 (9), 2234-2244, 2017 | 45 | 2017 |
| Development of a novel quantitative structure-activity relationship model to accurately predict pulmonary absorption and replace routine use of the isolated perfused respiring … CD Edwards, C Luscombe, P Eddershaw, EM Hessel Pharmaceutical research 33, 2604-2616, 2016 | 34 | 2016 |
| Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: a study in ex vivo lung models using chemical inhibition and genetic knockout G Al-Jayyoussi, DF Price, D Francombe, G Taylor, MW Smith, C Morris, ... Journal of Pharmaceutical Sciences 102 (9), 3382-3394, 2013 | 33 | 2013 |
| Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR RM Angell, TD Angell, P Bamborough, D Brown, M Brown, JB Buckton, ... Bioorganic & medicinal chemistry letters 18 (1), 324-328, 2008 | 32 | 2008 |
| A systems approach to routing global gridded runoff through local high-resolution stream networks for flood early warning systems X Qiao, EJ Nelson, DP Ames, Z Li, CH David, GP Williams, W Roberts, ... Environmental modelling & software 120, 104501, 2019 | 30 | 2019 |
| Methacholine delays pulmonary absorption of inhaled β2-agonists due to competition for organic cation/carnitine transporters M Gnadt, B Trammer, M Freiwald, B Kardziev, MK Bayliss, CD Edwards, ... Pulmonary Pharmacology & Therapeutics 25 (1), 124-134, 2012 | 23 | 2012 |
| Optimization of orally bioavailable PI3Kδ inhibitors and identification of Vps34 as a key selectivity target ZA Henley, A Amour, N Barton, M Bantscheff, G Bergamini, SM Bertrand, ... Journal of Medicinal Chemistry 63 (2), 638-655, 2019 | 20 | 2019 |
| The differential absorption of a series of P-glycoprotein substrates in isolated perfused lungs from Mdr1a/1b genetic knockout mice can be attributed to distinct physico … DF Price, CN Luscombe, PJ Eddershaw, CD Edwards, M Gumbleton Pharmaceutical Research 34, 2498-2516, 2017 | 17 | 2017 |
| Translation of inhaled drug optimization strategies into clinical pharmacokinetics and pharmacodynamics using gsk2292767a, a novel inhaled phosphoinositide 3-kinase δ inhibitor M Begg, CD Edwards, JN Hamblin, E Pefani, R Wilson, J Gilbert, G Vitulli, ... Journal of Pharmacology and Experimental Therapeutics 369 (3), 443-453, 2019 | 14 | 2019 |
| Functional role of P-gp efflux in limiting pulmonary drug absorption within an intact lung: application of an isolated perfused rat lung model D Francombe, G Taylor, S Taylor, G Somers, CD Edwards, M Gumbleton Respir Drug Deliv, 461-464, 2008 | 13 | 2008 |
| Comparison of the bronchodilating effects of inhaled β2-agonists after methacholine challenge in a human lung reperfusion model M Gnadt, B Trammer, B Kardziev, MK Bayliss, CD Edwards, M Schmidt, ... European journal of pharmaceutics and biopharmaceutics 81 (3), 617-626, 2012 | 12 | 2012 |
| Evolution of the role 4 UK military pain service L Devonport, D Edwards, C Edwards, DJ Aldington, PF Mahoney, P Wood BMJ Military Health 156 (Suppl 4), S398-401, 2010 | 11 | 2010 |
| Physiologically based pharmacokinetic modelling of inhaled nemiralisib: mechanistic components for pulmonary absorption, systemic distribution, and oral absorption NA Miller, RH Graves, CD Edwards, A Amour, E Taylor, O Robb, ... Clinical Pharmacokinetics, 1-13, 2022 | 8 | 2022 |
| PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation S Uddin, A Amour, DJ Lewis, CD Edwards, MG Williamson, S Hall, ... BMC immunology 22 (1), 78, 2021 | 4 | 2021 |
| Global Water Sustainability Tools from Earth Observations for the Americas J Nelson, J Biesinger, N Jones, DP Ames, R Hales, GP Williams, ... AGU Fall Meeting Abstracts 2019, GC41C-07, 2019 | 3 | 2019 |
| H~ Sgger, P. and Sade6, W.(1993) J O Moro, J Lamek Biol. Chem 268, 22273-22276, 0 | 2 | |
| The effect of environment on level of resistance to Phomopsis leptostromiformis in lupins and implications for resistance breeding to this disease J Hamblin, PMR Wood, C Edwards Euphytica 33, 443-446, 1984 | 1 | 1984 |
| Forecasting Inundation Extents and Flood Impact in the Amazon Basin C Edwards, J Nelson, E Smith, MA Ernesto de Moraes, ... AGU Fall Meeting Abstracts 2020, GC103-0012, 2020 | | 2020 |
