|Fit-for-purpose method development and validation for successful biomarker measurement|
JW Lee, V Devanarayan, YC Barrett, R Weiner, J Allinson, S Fountain, ...
Pharmaceutical research 23 (2), 312-328, 2006
|Thrombin responses in human endothelial cells: contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1|
PJ O'Brien, N Prevost, M Molino, MK Hollinger, MJ Woolkalis, DS Woulfe, ...
Journal of Biological Chemistry 275 (18), 13502-13509, 2000
|The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins|
PJ O’Brien, WE Alborn, JH Sloan, M Ulmer, A Boodhoo, MD Knierman, ...
Clinical chemistry 51 (2), 351-359, 2005
|Protease activated receptors: theme and variations|
PJ O'Brien, M Molino, M Kahn, LF Brass
Oncogene 20 (13), 1570-1581, 2001
|Altered G Protein‐Coupling Functions of RNA Editing Isoform and Splicing Variant Serotonin2C Receptors|
Q Wang, PJ O'Brien, CX Chen, DSC Cho, JM Murray, K Nishikura
Journal of neurochemistry 74 (3), 1290-1300, 2000
|Toward ‘omic scale metabolite profiling: a dual separation–mass spectrometry approach for coverage of lipid and central carbon metabolism|
J Ivanisevic, ZJ Zhu, L Plate, R Tautenhahn, S Chen, PJ O’Brien, ...
Analytical chemistry 85 (14), 6876-6884, 2013
|Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1|
M Riewald, VV Kravchenko, RJ Petrovan, PJ O'Brien, LF Brass, ...
Blood, The Journal of the American Society of Hematology 97 (10), 3109-3116, 2001
|Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs|
J Yang, J Wu, MA Kowalska, A Dalvi, N Prevost, PJ O'Brien, D Manning, ...
Proceedings of the National Academy of Sciences 97 (18), 9984-9989, 2000
|Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report|
JW Lee, RS Weiner, JM Sailstad, RR Bowsher, DW Knuth, PJ O’Brien, ...
Pharmaceutical research 22 (4), 499-511, 2005
|Evaluation of the substrate specificity of human mast cell tryptase βI and demonstration of its importance in bacterial infections of the lung|
C Huang, GT De Sanctis, PJ O'Brien, JP Mizgerd, DS Friend, JM Drazen, ...
Journal of Biological Chemistry 276 (28), 26276-26284, 2001
|Measurement of insulin-like growth factor-II in physiological fluids and tissues. I. An improved extraction procedure and radioimmunoassay for human and rat fluids|
RR BOWSHER, WEIHUA LEE, JM APATHY, PJ O’BRIEN, AL FERGUSON, ...
Endocrinology 128 (2), 805-814, 1991
|[18F] FLT–PET imaging does not always “light up” proliferating tumor cells|
CC Zhang, Z Yan, W Li, K Kuszpit, CL Painter, Q Zhang, PB Lappin, ...
Clinical Cancer Research 18 (5), 1303-1312, 2012
|The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models|
S Palsson, TP Hickling, EL Bradshaw-Pierce, M Zager, K Jooss, ...
BMC systems biology 7 (1), 1-19, 2013
|Genes that can be mutated to unmask hidden antigenic determinants in the cuticle of the nematode Caenorhabditis elegans.|
SM Politz, M Philipp, M Estevez, PJ O'Brien, KJ Chin
Proceedings of the National Academy of Sciences 87 (8), 2901-2905, 1990
|Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro|
PJ O'Brien, H Koi, S Parry, LF Brass, JF Strauss III, LP Wang, ...
The American journal of pathology 163 (4), 1245-1254, 2003
|Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging|
PJ O’Brien, M Lee, ME Spilker, CC Zhang, Z Yan, TC Nichols, W Li, ...
Cancer & Metabolism 1 (1), 1-14, 2013
|Factor XIa–specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis|
T David, YC Kim, LK Ely, I Rondon, H Gao, P O’Brien, MW Bolt, AJ Coyle, ...
Science translational medicine 8 (353), 353ra112-353ra112, 2016
|Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids|
ME Kurczy, ZJ Zhu, J Ivanisevic, AM Schuyler, K Lalwani, AF Santidrian, ...
Nature communications 6 (1), 1-8, 2015
|Signal transduction during the initiation, extension, and perpetuation of platelet plug formation|
D Woulfe, J Yang, N Prevost, PJ O’Brien, LF Brass
Platelets, 197-213, 2002
|Recommendations for the evaluation of specimen stability for flow cytometric testing during drug development|
L Brown, CL Green, N Jones, JJ Stewart, S Fraser, K Howell, Y Xu, ...
Journal of immunological methods 418, 1-8, 2015