Targeting protein tyrosine phosphatase PTP-PEST (PTPN12) for therapeutic intervention in acute myocardial infarction CF Yang, YY Chen, JP Singh, SF Hsu, YW Liu, CY Yang, CW Chang, ... Cardiovascular research 116 (5), 1032-1046, 2020 | 22 | 2020 |
The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1 JP Singh, Y Li, YY Chen, STD Hsu, R Page, W Peti, TC Meng Nature communications 13 (1), 94, 2022 | 16 | 2022 |
Crystal structure of TCPTP unravels an allosteric regulatory role of helix α7 in phosphatase activity JP Singh, MJ Lin, SF Hsu, W Peti, CC Lee, TC Meng Biochemistry 60 (51), 3856-3867, 2021 | 15 | 2021 |
Active-site cysteine 215 sulfonation targets protein tyrosine phosphatase PTP1B for Cullin1 E3 ligase-mediated degradation CY Yang, CF Yang, XF Tang, LESF Machado, JP Singh, W Peti, CS Chen, ... Free Radical Biology and Medicine 194, 147-159, 2023 | 2 | 2023 |
Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte MF Hsu, Y Ito, JP Singh, SF Hsu, A Wells, KY Jen, TC Meng, FG Haj Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1871 (1), 119590, 2024 | | 2024 |
Application of hybrid biophysical-biochemical methods to unravel the molecular basis for auto-inhibition and activation of protein tyrosine phosphatase TCPTP/PTPN2 JP Singh, YY Chen, YT Huang, STD Hsu, TC Meng Methods in Enzymology 682, 351-374, 2023 | | 2023 |
Old Drug New Tricks: Repurposing Auranofin for Acute Myocardial Infarction by Targeting Protein Tyrosine Phosphatase PTP-PEST CF Yang, YY Chen, YW Liu, JP Singh, CW Chang, CF Cheng, TC Meng Circulation Research 123 (Suppl_1), A297-A297, 2018 | | 2018 |