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Steve McGaraughty
Steve McGaraughty
Bestätigte E-Mail-Adresse bei abbvie.com
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A-803467, a potent and selective Nav1. 8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
MF Jarvis, P Honore, CC Shieh, M Chapman, S Joshi, XF Zhang, M Kort, ...
Proceedings of the National Academy of Sciences 104 (20), 8520-8525, 2007
6112007
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
MF Jarvis, EC Burgard, S McGaraughty, P Honore, K Lynch, TJ Brennan, ...
Proceedings of the National Academy of Sciences 99 (26), 17179-17184, 2002
5572002
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
J Chen, SK Joshi, S DiDomenico, RJ Perner, JP Mikusa, DM Gauvin, ...
Pain 152 (5), 1165-1172, 2011
3122011
P2X7-related modulation of pathological nociception in rats
S McGaraughty, KL Chu, MT Namovic, DL Donnelly-Roberts, RR Harris, ...
Neuroscience 146 (4), 1817-1828, 2007
2692007
Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and …
S McGaraughty, CT Wismer, CZ Zhu, J Mikusa, P Honore, KL Chu, ...
British journal of pharmacology 140 (8), 1381-1388, 2003
2192003
Painful purinergic receptors
D Donnelly-Roberts, S McGaraughty, CC Shieh, P Honore, MF Jarvis
Journal of Pharmacology and Experimental Therapeutics 324 (2), 409-415, 2008
2012008
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats
S McGaraughty, KL Chu, RJ Perner, S DiDomenico, ME Kort, PR Kym
Molecular pain 6, 1744-8069-6-14, 2010
1942010
Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla
MM Heinricher, S McGaraughty, V Tortorici
Journal of neurophysiology 85 (1), 280-286, 2001
1442001
Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM
S McGaraughty, KL Chu, RS Bitner, B Martino, RE Kouhen, P Han, ...
Journal of neurophysiology 90 (4), 2702-2710, 2003
1392003
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial
MC Rowbotham, W Nothaft, WR Duan, Y Wang, C Faltynek, ...
Pain 152 (5), 1192-1200, 2011
1232011
Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity
S McGaraughty, MM Heinricher
Pain 96 (1-2), 153-162, 2002
1212002
Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla
MM Heinricher, S McGaraughty, DK Grandy
Journal of Neurophysiology 78 (6), 3351-3358, 1997
1201997
Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors
S McGaraughty, M Cowart, MF Jarvis, RF Berman
Current topics in medicinal chemistry 5 (1), 43-58, 2005
1192005
Design of adenosine kinase inhibitors from the NMR-based screening of fragments
PJ Hajduk, A Gomtsyan, S Didomenico, M Cowart, EK Bayburt, ...
Journal of medicinal chemistry 43 (25), 4781-4786, 2000
1002000
The role of excitatory amino acid transmission within the rostral ventromedial medulla in the antinociceptive actions of systemically administered morphine
MM Heinricher, S McGaraughty, DA Farr
Pain 81 (1-2), 57-65, 1999
831999
A selective Nav1. 8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3, 5-dimethoxyphenyl) furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats
S McGaraughty, KL Chu, MJC Scanio, ME Kort, CR Faltynek, MF Jarvis
Journal of Pharmacology and Experimental Therapeutics 324 (3), 1204-1211, 2008
822008
A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats
MF Jarvis, VE Scott, S McGaraughty, KL Chu, J Xu, W Niforatos, I Milicic, ...
Biochemical pharmacology 89 (4), 536-544, 2014
772014
Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala
S McGaraughty, DA Farr, MM Heinricher
Brain research 1009 (1-2), 223-227, 2004
712004
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl) pyrido [2, 3-d] pyrimidin-4-ylamine: structure–activity relationships of 7-substituted heteroaryl analogs as non-nucleoside …
MA Matulenko, CH Lee, M Jiang, RR Frey, MD Cowart, EK Bayburt, ...
Bioorganic & medicinal chemistry 13 (11), 3705-3720, 2005
682005
Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor
MF Jarvis, H Yu, S McGaraughty, CT Wismer, J Mikusa, C Zhu, K Chu, ...
Pain 96 (1-2), 107-118, 2002
682002
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