| Accurate prediction of protein structures and interactions using a three-track neural network M Baek, F DiMaio, I Anishchenko, J Dauparas, S Ovchinnikov, GR Lee, ... Science 373 (6557), 871-876, 2021 | 3365 | 2021 |
| A mechanical switch couples T cell receptor triggering to the cytoplasmic juxtamembrane regions of CD3ζζ MS Lee, CR Glassman, NR Deshpande, HB Badgandi, HL Parrish, ... Immunity 43 (2), 227-239, 2015 | 117 | 2015 |
| An engineered IL-2 partial agonist promotes CD8+ T cell stemness F Mo, Z Yu, P Li, J Oh, R Spolski, L Zhao, CR Glassman, TN Yamamoto, ... Nature 597 (7877), 544-548, 2021 | 105 | 2021 |
| Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells CR Glassman, YK Mathiharan, KM Jude, L Su, O Panova, PJ Lupardus, ... Cell 184 (4), 983-999. e24, 2021 | 87 | 2021 |
| Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation CR Glassman, N Tsutsumi, RA Saxton, PJ Lupardus, KM Jude, KC Garcia Science 376 (6589), 163-169, 2022 | 82 | 2022 |
| Emerging principles of cytokine pharmacology and therapeutics RA Saxton, CR Glassman, KC Garcia Nature Reviews Drug Discovery 22 (1), 21-37, 2023 | 48 | 2023 |
| Facile discovery of surrogate cytokine agonists M Yen, J Ren, Q Liu, CR Glassman, TP Sheahan, LK Picton, FR Moreira, ... Cell 185 (8), 1414-1430. e19, 2022 | 34 | 2022 |
| Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo RA Fernandes, C Li, G Wang, X Yang, CS Savvides, CR Glassman, ... Elife 9, e58463, 2020 | 30 | 2020 |
| Reciprocal TCR-CD3 and CD4 engagement of a nucleating pMHCII stabilizes a functional receptor macrocomplex CR Glassman, HL Parrish, MS Lee, MS Kuhns Cell reports 22 (5), 1263-1275, 2018 | 27 | 2018 |
| Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro MH Gee, LV Sibener, ME Birnbaum, KM Jude, X Yang, RA Fernandes, ... Proceedings of the National Academy of Sciences 115 (31), E7369-E7378, 2018 | 26 | 2018 |
| Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist CR Glassman, L Su, SS Majri-Morrison, H Winkelmann, F Mo, P Li, ... Elife 10, e65777, 2021 | 25 | 2021 |
| Interleukin-2 Druggability is Modulated by Global Conformational Transitions that are Controlled by a Helical Capping Switch V De Paula, KM Jude, S Nerli, CR Glassman, KC Garcia, N Sgourakis Biophysical Journal 118 (3), 51a, 2020 | 24 | 2020 |
| A transmembrane domain GGxxG motif in CD4 contributes to its Lck-independent function but does not mediate CD4 dimerization HL Parrish, CR Glassman, MM Keenen, NR Deshpande, MP Bronnimann, ... PLoS One 10 (7), e0132333, 2015 | 24 | 2015 |
| Structure of the IL-27 quaternary receptor signaling complex NA Caveney, CR Glassman, KM Jude, N Tsutsumi, KC Garcia Elife 11, e78463, 2022 | 21 | 2022 |
| Structural basis of Janus kinase trans-activation NA Caveney, RA Saxton, D Waghray, CR Glassman, N Tsutsumi, ... Cell reports 42 (3), 2023 | 15 | 2023 |
| Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination N Tsutsumi, S Hwang, D Waghray, S Hansen, KM Jude, N Wang, Y Miao, ... Proceedings of the National Academy of Sciences 120 (11), e2218238120, 2023 | 11 | 2023 |
| The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR–CD3–pMHC–CD4 Macrocomplex CR Glassman, HL Parrish, NR Deshpande, MS Kuhns The Journal of Immunology 196 (11), 4713-4722, 2016 | 11 | 2016 |
| Deploying synthetic coevolution and machine learning to engineer protein-protein interactions A Yang, KM Jude, B Lai, M Minot, AM Kocyla, CR Glassman, D Nishimiya, ... Science 381 (6656), eadh1720, 2023 | 5 | 2023 |
| Partial agonists of interleukin-2 KC Garcia, SS Majri, CR Glassman, LLR SU US Patent App. 16/765,617, 2020 | 5 | 2020 |
| Engineered il-12 and il-23 polypeptides and uses thereof KC Garcia, CR Glassman US Patent App. 17/995,986, 2023 | | 2023 |
