Caleb R Glassman
Caleb R Glassman
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Accurate prediction of protein structures and interactions using a three-track neural network
M Baek, F DiMaio, I Anishchenko, J Dauparas, S Ovchinnikov, GR Lee, ...
Science 373 (6557), 871-876, 2021
A mechanical switch couples T cell receptor triggering to the cytoplasmic juxtamembrane regions of CD3ζζ
MS Lee, CR Glassman, NR Deshpande, HB Badgandi, HL Parrish, ...
Immunity 43 (2), 227-239, 2015
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
F Mo, Z Yu, P Li, J Oh, R Spolski, L Zhao, CR Glassman, TN Yamamoto, ...
Nature 597 (7877), 544-548, 2021
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells
CR Glassman, YK Mathiharan, KM Jude, L Su, O Panova, PJ Lupardus, ...
Cell 184 (4), 983-999. e24, 2021
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
CR Glassman, N Tsutsumi, RA Saxton, PJ Lupardus, KM Jude, KC Garcia
Science 376 (6589), 163-169, 2022
Emerging principles of cytokine pharmacology and therapeutics
RA Saxton, CR Glassman, KC Garcia
Nature Reviews Drug Discovery 22 (1), 21-37, 2023
Facile discovery of surrogate cytokine agonists
M Yen, J Ren, Q Liu, CR Glassman, TP Sheahan, LK Picton, FR Moreira, ...
Cell 185 (8), 1414-1430. e19, 2022
Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo
RA Fernandes, C Li, G Wang, X Yang, CS Savvides, CR Glassman, ...
Elife 9, e58463, 2020
Reciprocal TCR-CD3 and CD4 engagement of a nucleating pMHCII stabilizes a functional receptor macrocomplex
CR Glassman, HL Parrish, MS Lee, MS Kuhns
Cell reports 22 (5), 1263-1275, 2018
Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro
MH Gee, LV Sibener, ME Birnbaum, KM Jude, X Yang, RA Fernandes, ...
Proceedings of the National Academy of Sciences 115 (31), E7369-E7378, 2018
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist
CR Glassman, L Su, SS Majri-Morrison, H Winkelmann, F Mo, P Li, ...
Elife 10, e65777, 2021
Interleukin-2 Druggability is Modulated by Global Conformational Transitions that are Controlled by a Helical Capping Switch
V De Paula, KM Jude, S Nerli, CR Glassman, KC Garcia, N Sgourakis
Biophysical Journal 118 (3), 51a, 2020
A transmembrane domain GGxxG motif in CD4 contributes to its Lck-independent function but does not mediate CD4 dimerization
HL Parrish, CR Glassman, MM Keenen, NR Deshpande, MP Bronnimann, ...
PLoS One 10 (7), e0132333, 2015
Structure of the IL-27 quaternary receptor signaling complex
NA Caveney, CR Glassman, KM Jude, N Tsutsumi, KC Garcia
Elife 11, e78463, 2022
Structural basis of Janus kinase trans-activation
NA Caveney, RA Saxton, D Waghray, CR Glassman, N Tsutsumi, ...
Cell reports 42 (3), 2023
Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination
N Tsutsumi, S Hwang, D Waghray, S Hansen, KM Jude, N Wang, Y Miao, ...
Proceedings of the National Academy of Sciences 120 (11), e2218238120, 2023
The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR–CD3–pMHC–CD4 Macrocomplex
CR Glassman, HL Parrish, NR Deshpande, MS Kuhns
The Journal of Immunology 196 (11), 4713-4722, 2016
Deploying synthetic coevolution and machine learning to engineer protein-protein interactions
A Yang, KM Jude, B Lai, M Minot, AM Kocyla, CR Glassman, D Nishimiya, ...
Science 381 (6656), eadh1720, 2023
Partial agonists of interleukin-2
KC Garcia, SS Majri, CR Glassman, LLR SU
US Patent App. 16/765,617, 2020
Engineered il-12 and il-23 polypeptides and uses thereof
KC Garcia, CR Glassman
US Patent App. 17/995,986, 2023
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