| Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ... Cell 173 (3), 677-692. e20, 2018 | 418 | 2018 |
| RNA binding antagonizes neurotoxic phase transitions of TDP-43 JR Mann, AM Gleixner, JC Mauna, E Gomes, MR DeChellis-Marks, ... Neuron 102 (2), 321-338. e8, 2019 | 387 | 2019 |
| Cytoplasmic TDP-43 de-mixing independent of stress granules drives inhibition of nuclear import, loss of nuclear TDP-43, and cell death F Gasset-Rosa, S Lu, H Yu, C Chen, Z Melamed, L Guo, J Shorter, ... Neuron 102 (2), 339-357. e7, 2019 | 356 | 2019 |
| Poly (ADP-ribose) prevents pathological phase separation of TDP-43 by promoting liquid Demixing and stress granule localization L McGurk, E Gomes, L Guo, J Mojsilovic-Petrovic, V Tran, RG Kalb, ... Molecular cell 71 (5), 703-717. e9, 2018 | 345 | 2018 |
| Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity YJ Zhang, L Guo, PK Gonzales, TF Gendron, Y Wu, K Jansen-West, ... Science 363 (6428), eaav2606, 2019 | 205 | 2019 |
| Divalent cation-induced cluster formation by polyphosphoinositides in model membranes YH Wang, A Collins, L Guo, KB Smith-Dupont, F Gai, T Svitkina, ... Journal of the American Chemical Society 134 (7), 3387-3395, 2012 | 139 | 2012 |
| Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations AG Niaki, J Sarkar, X Cai, K Rhine, V Vidaurre, B Guy, M Hurst, JC Lee, ... Molecular Cell, 2019 | 134 | 2019 |
| It’s Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles L Guo, J Shorter Molecular cell 60 (2), 189-192, 2015 | 132 | 2015 |
| Stress induces dynamic, cytotoxicity-antagonizing TDP-43 nuclear bodies via paraspeckle lncRNA NEAT1-mediated liquid-liquid phase separation C Wang, Y Duan, G Duan, Q Wang, K Zhang, X Deng, B Qian, J Gu, Z Ma, ... Molecular Cell 79 (3), 443-458. e7, 2020 | 125 | 2020 |
| Effect of macromolecular crowding on protein folding dynamics at the secondary structure level S Mukherjee, MM Waegele, P Chowdhury, L Guo, F Gai Journal of molecular biology 393 (1), 227-236, 2009 | 119 | 2009 |
| FUS regulates activity of MicroRNA-mediated gene silencing T Zhang, YC Wu, P Mullane, YJ Ji, H Liu, L He, A Arora, HY Hwang, ... Molecular cell 69 (5), 787-801. e8, 2018 | 97 | 2018 |
| Interaction of fullerenol with lysozyme investigated by experimental and computational approaches ST Yang, H Wang, L Guo, Y Gao, Y Liu, A Cao Nanotechnology 19 (39), 395101, 2008 | 80 | 2008 |
| Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity E Bogaert, S Boeynaems, M Kato, L Guo, TR Caulfield, J Steyaert, ... Cell Reports 24 (3), 529-537. e4, 2018 | 77 | 2018 |
| Biology and pathobiology of TDP-43 and emergent therapeutic strategies L Guo, J Shorter Cold Spring Harb. Perspect. Med., doi: 10.1101/cshperspect.a024554., 2016 | 73 | 2016 |
| Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors L Guo, CM Fare, J Shorter Trends in Cell Biology, 2019 | 64 | 2019 |
| Liquid-liquid phase separation of TDP-43 and FUS in physiology and pathology of neurodegenerative diseases JL Carey, L Guo Frontiers in Molecular Biosciences 9, 826719, 2022 | 58 | 2022 |
| Heterogeneous and anomalous diffusion inside lipid tubules L Guo, P Chowdhury, J Fang, F Gai The journal of physical chemistry B 111 (51), 14244-14249, 2007 | 54 | 2007 |
| Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation D Beijer, HJ Kim, L Guo, K O’Donovan, I Mademan, T Deconinck, ... JCI insight 6 (14), 2021 | 39 | 2021 |
| Denaturant-induced expansion and compaction of a multi-domain protein: IgG L Guo, P Chowdhury, JM Glasscock, F Gai Journal of molecular biology 384 (5), 1029-1036, 2008 | 30 | 2008 |
| Poly (ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation L McGurk, E Gomes, L Guo, J Shorter, NM Bonini Biochemistry 57 (51), 6923-6926, 2018 | 29 | 2018 |
