Nanoparticles containing oxidized cholesterol deliver mRNA to the liver microenvironment at clinically relevant doses K Paunovska, AJ Da Silva Sanchez, CD Sago, Z Gan, MP Lokugamage, ... Advanced materials 31 (14), 1807748, 2019 | 147 | 2019 |
Treating cystic fibrosis with mRNA and CRISPR A Da Silva Sanchez, K Paunovska, A Cristian, JE Dahlman Human gene therapy 31 (17-18), 940-955, 2020 | 52 | 2020 |
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery C Dobrowolski, K Paunovska, E Schrader Echeverri, D Loughrey, ... Nature Nanotechnology 17 (8), 871-879, 2022 | 40 | 2022 |
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo A Radmand, MP Lokugamage, H Kim, C Dobrowolski, R Zenhausern, ... Nano letters 23 (3), 993-1002, 2023 | 23 | 2023 |
Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery AJ Da Silva Sanchez, C Dobrowolski, A Cristian, ES Echeverri, K Zhao, ... Nano Letters 22 (12), 4822-4830, 2022 | 23 | 2022 |
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery MZC Hatit, CN Dobrowolski, MP Lokugamage, D Loughrey, H Ni, C Zurla, ... Nature Chemistry 15 (4), 508-515, 2023 | 22 | 2023 |
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo SG Huayamares, MP Lokugamage, R Rab, AJDS Sanchez, H Kim, ... Journal of Controlled Release 357, 394-403, 2023 | 21 | 2023 |
Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery AJDS Sanchez, K Zhao, SG Huayamares, MZC Hatit, MP Lokugamage, ... Journal of Controlled Release 353, 270-277, 2023 | 20 | 2023 |
Increased PIP3 activity blocks nanoparticle mRNA delivery K Paunovska, A Da Silva Sanchez, MT Foster, D Loughrey, EL Blanchard, ... Science advances 6 (30), eaba5672, 2020 | 19 | 2020 |
The extent to which lipid nanoparticles require apolipoprotein E and low-density lipoprotein receptor for delivery changes with ionizable lipid structure K Paunovska, AJ Da Silva Sanchez, MP Lokugamage, D Loughrey, ... Nano Letters 22 (24), 10025-10033, 2022 | 13 | 2022 |
A systematic analysis of biotech startups that went public in the first half of 2021 SG Huayamares, MP Lokugamage, AJDS Sanchez, JE Dahlman Current Research in Biotechnology 4, 392-401, 2022 | 9 | 2022 |
Substituting Poly (Ethylene Glycol) Lipids with Poly (2‐Ethyl‐2‐Oxazoline) Lipids Improves Lipid Nanoparticle Repeat Dosing AJDS Sanchez, D Loughrey, ES Echeverri, SG Huayamares, A Radmand, ... Advanced Healthcare Materials, 2304033, 2024 | 1 | 2024 |