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John Flanagan
John Flanagan
Tasca Therapeutics
Verified email at tascatx.com
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Cited by
Cited by
Year
Catalytic in vivo protein knockdown by small-molecule PROTACs
DP Bondeson, A Mares, IED Smith, E Ko, S Campos, AH Miah, ...
Nature chemical biology 11 (8), 611-617, 2015
10492015
The pharmacological chaperone 1‐deoxygalactonojirimycin increases α‐galactosidase A levels in Fabry patient cell lines
ER Benjamin, JJ Flanagan, A Schilling, HH Chang, L Agarwal, E Katz, ...
Journal of Inherited Metabolic Disease: Official Journal of the Society for …, 2009
2092009
Identification and characterization of pharmacological chaperones to correct enzyme deficiencies in lysosomal storage disorders
KJ Valenzano, R Khanna, AC Powe Jr, R Boyd, G Lee, JJ Flanagan, ...
Assay and drug development technologies 9 (3), 213-235, 2011
1952011
The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic
R Behnia, FA Barr, JJ Flanagan, C Barlowe, S Munro
The Journal of cell biology 176 (3), 255-261, 2007
1742007
Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens
JJ Flanagan, JC Chen, Y Miao, Y Shao, J Lin, PE Bock, AE Johnson
Journal of biological chemistry 278 (20), 18628-18637, 2003
1592003
Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding
JJ Flanagan, RK Tweten, AE Johnson, AP Heuck
Biochemistry 48 (18), 3977-3987, 2009
1462009
The pharmacological chaperone 1‐deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha‐glucosidase
JJ Flanagan, B Rossi, K Tang, X Wu, K Mascioli, F Donaudy, MR Tuzzi, ...
Human mutation 30 (12), 1683-1692, 2009
1262009
Abstract P5-04-18: ARV-471, an oral estrogen receptor PROTAC degrader for breast cancer
JJ Flanagan, Y Qian, SM Gough, M Andreoli, M Bookbinder, G Cadelina, ...
Cancer research 79 (4_Supplement), P5-04-18-P5-04-18, 2019
1102019
Co-administration with the pharmacological chaperone AT1001 increases recombinant human α-galactosidase A tissue uptake and improves substrate reduction in Fabry mice
ER Benjamin, R Khanna, A Schilling, JJ Flanagan, LJ Pellegrino, ...
Molecular Therapy 20 (4), 717-726, 2012
1072012
A GCase chaperone improves motor function in a mouse model of synucleinopathy
F Richter, SM Fleming, M Watson, V Lemesre, L Pellegrino, B Ranes, ...
Neurotherapeutics 11 (4), 840-856, 2014
1032014
A pharmacogenetic approach to identify mutant forms of α‐galactosidase a that respond to a pharmacological chaperone for Fabry disease
X Wu, E Katz, MCD Valle, K Mascioli, JJ Flanagan, JP Castelli, ...
Human mutation 32 (8), 965-977, 2011
952011
The pharmacological chaperone AT2220 increases recombinant human acid α-glucosidase uptake and glycogen reduction in a mouse model of Pompe disease
R Khanna, JJ Flanagan, J Feng, R Soska, M Frascella, LJ Pellegrino, ...
PloS one 7 (7), e40776, 2012
902012
Methods of in situ detection of nucleic acids
Y Luo, HY Wang, JJ Flanagan, S Chen
US Patent App. 13/575,936, 2013
892013
Oral migalastat HCl leads to greater systemic exposure and tissue levels of active α-galactosidase A in Fabry patients when co-administered with infused agalsidase
DG Warnock, DG Bichet, M Holida, O Goker-Alpan, K Nicholls, M Thomas, ...
PLoS One 10 (8), e0134341, 2015
742015
The discovery of ARV-471, an orally bioavailable estrogen receptor degrading PROTAC for the treatment of patients with breast cancer
LB Snyder, JJ Flanagan, Y Qian, SM Gough, M Andreoli, M Bookbinder, ...
Cancer Res 81 (13), 44, 2021
692021
Targeting nuclear receptors with PROTAC degraders
JJ Flanagan, TK Neklesa
Molecular and cellular endocrinology 493, 110452, 2019
632019
Method to predict response to pharmacological chaperone treatment of diseases
E Benjamin, HV Do, X Wu, J Flanagan, B Wustman
US Patent 8,592,362, 2013
582013
Duvoglustat HCl increases systemic and tissue exposure of active acid α-glucosidase in Pompe patients co-administered with alglucosidase α
P Kishnani, M Tarnopolsky, M Roberts, K Sivakumar, M Dasouki, ...
Molecular Therapy 25 (5), 1199-1208, 2017
522017
Sec22p export from the endoplasmic reticulum is independent of SNARE pairing
Y Liu, JJ Flanagan, C Barlowe
Journal of Biological Chemistry 279 (26), 27225-27232, 2004
522004
Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
Y Luo, S Chen, HYF Wang, JJ Flanagan
US Patent App. 12/284,163, 2009
492009
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