Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ... Nature biotechnology 34 (2), 184-191, 2016 | 4248 | 2016 |
Gaussian Processes for Big Data J Hensman, N Fusi, ND Lawrence Uncertainty in Artificial Intelligence, 2013 | 1563 | 2013 |
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs J Listgarten, M Weinstein, BP Kleinstiver, AA Sousa, JK Joung, J Crawford, ... Nature biomedical engineering 2 (1), 38-47, 2018 | 307 | 2018 |
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens FJ Najm, C Strand, KF Donovan, M Hegde, KR Sanson, EW Vaimberg, ... Nature biotechnology 36 (2), 179-189, 2018 | 302 | 2018 |
Can generalist foundation models outcompete special-purpose tuning? case study in medicine H Nori, YT Lee, S Zhang, D Carignan, R Edgar, N Fusi, N King, J Larson, ... arXiv preprint arXiv:2311.16452, 2023 | 233 | 2023 |
Geometric dataset distances via optimal transport D Alvarez-Melis, N Fusi Advances in Neural Information Processing Systems 33, 21428-21439, 2020 | 209 | 2020 |
Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and … A Brockington, K Ning, PR Heath, E Wood, J Kirby, N Fusi, N Lawrence, ... Acta neuropathologica 125, 95-109, 2013 | 178 | 2013 |
Probabilistic matrix factorization for automated machine learning N Fusi, R Sheth, M Elibol Advances in neural information processing systems 31, 2018 | 165 | 2018 |
Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies N Fusi, O Stegle, ND Lawrence PLoS computational biology 8 (1), e1002330, 2012 | 154 | 2012 |
Gaussian process prior variational autoencoders FP Casale, A Dalca, L Saglietti, J Listgarten, N Fusi Advances in neural information processing systems 31, 2018 | 148 | 2018 |
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control I Bartha, JM Carlson, CJ Brumme, PJ McLaren, ZL Brumme, M John, ... elife 2, e01123, 2013 | 148 | 2013 |
Impact of pre-adapted HIV transmission JM Carlson, VY Du, N Pfeifer, A Bansal, VYF Tan, K Power, CJ Brumme, ... Nature medicine 22 (6), 606-613, 2016 | 111 | 2016 |
Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis G Nardo, R Iennaco, N Fusi, PR Heath, M Marino, MC Trolese, ... Brain 136 (11), 3305-3332, 2013 | 105 | 2013 |
Convolutions are competitive with transformers for protein sequence pretraining KK Yang, N Fusi, AX Lu Cell Systems 15 (3), 286-294. e2, 2024 | 96 | 2024 |
Further Improvements to Linear Mixed Models for Genome-Wide Association Studies C Widmer, C Lippert, O Weissbrod, N Fusi, C Kadie, R Davidson, ... Scientific Reports 4, 2014 | 89 | 2014 |
Probabilistic neural architecture search FP Casale, J Gordon, N Fusi arXiv preprint arXiv:1902.05116, 2019 | 88 | 2019 |
Protein generation with evolutionary diffusion: sequence is all you need S Alamdari, N Thakkar, R van den Berg, N Tenenholtz, B Strome, ... BioRxiv, 2023.09. 11.556673, 2023 | 62 | 2023 |
Warped linear mixed models for the genetic analysis of transformed phenotypes N Fusi, C Lippert, ND Lawrence, O Stegle Nature communications 5 (1), 4890, 2014 | 61 | 2014 |
Virchow: A million-slide digital pathology foundation model E Vorontsov, A Bozkurt, A Casson, G Shaikovski, M Zelechowski, S Liu, ... arXiv preprint arXiv:2309.07778, 2023 | 60 | 2023 |
Initialization and regularization of factorized neural layers M Khodak, N Tenenholtz, L Mackey, N Fusi arXiv preprint arXiv:2105.01029, 2021 | 56 | 2021 |