| A general tool for engineering the NAD/NADP cofactor preference of oxidoreductases JKB Cahn, CA Werlang, A Baumschlager, S Brinkmann-Chen, SL Mayo, ... ACS synthetic biology 6 (2), 326-333, 2017 | 162 | 2017 |
| Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models SC Dodani, G Kiss, JKB Cahn, Y Su, VS Pande, FH Arnold Nature chemistry 8 (5), 419-425, 2016 | 138 | 2016 |
| General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH S Brinkmann-Chen, T Flock, JKB Cahn, CD Snow, EM Brustad, ... Proceedings of the National Academy of Sciences 110 (27), 10946-10951, 2013 | 127 | 2013 |
| Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble AR Buller, P Van Roye, JKB Cahn, RA Scheele, M Herger, FH Arnold Journal of the American Chemical Society 140 (23), 7256-7266, 2018 | 93 | 2018 |
| Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts T Mori, JKB Cahn, MC Wilson, RA Meoded, V Wiebach, AFC Martinez, ... Proceedings of the National Academy of Sciences 115 (8), 1718-1723, 2018 | 91 | 2018 |
| Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore L Herwig, AJ Rice, CN Bedbrook, RK Zhang, A Lignell, JKB Cahn, ... Cell chemical biology 24 (3), 415-425, 2017 | 69 | 2017 |
| Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE SC Dodani, JKB Cahn, T Heinisch, S Brinkmann‐Chen, JA McIntosh, ... ChemBioChem 15 (15), 2259-2267, 2014 | 59 | 2014 |
| 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation SA Lieblich, KY Fang, JKB Cahn, J Rawson, J LeBon, HT Ku, DA Tirrell Journal of the American Chemical Society 139 (25), 8384-8387, 2017 | 51 | 2017 |
| Mutations in adenine-binding pockets enhance catalytic properties of NAD (P) H-dependent enzymes JKB Cahn, A Baumschlager, S Brinkmann-Chen, FH Arnold Protein Engineering Design and Selection 29 (1), 31-38, 2016 | 42 | 2016 |
| The use of trimethylamine N-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallography H Marshall, M Venkat, NS Hti Lar Seng, J Cahn, DH Juers Acta Crystallographica Section D: Biological Crystallography 68 (1), 69-81, 2012 | 35 | 2012 |
| A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds P Moosmann, F Ecker, S Leopold-Messer, JKB Cahn, CL Dieterich, ... Nature chemistry 12 (10), 968-972, 2020 | 32 | 2020 |
| Uncovering rare NADH-preferring ketol-acid reductoisomerases S Brinkmann-Chen, JKB Cahn, FH Arnold Metabolic engineering 26, 17-22, 2014 | 30 | 2014 |
| Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases JKB Cahn, S Brinkmann-Chen, T Spatzal, JA Wiig, AR Buller, O Einsle, ... Biochemical Journal 468 (3), 475-484, 2015 | 27 | 2015 |
| Single-cell metabolite detection and genomics reveals uncultivated talented producer M Kogawa, R Miyaoka, F Hemmerling, M Ando, K Yura, K Ide, ... PNAS nexus 1 (1), pgab007, 2022 | 20 | 2022 |
| Cell adhesion to borate glasses by colloidal probe microscopy SM Wiederhorn, YH Chae, CG Simon Jr, J Cahn, Y Deng, D Day Acta biomaterialia 7 (5), 2256-2263, 2011 | 19 | 2011 |
| Opening up the Single‐Cell Toolbox for Microbial Natural Products Research J Cahn, J Piel Angewandte Chemie International Edition, 2019 | 17 | 2019 |
| Effect of γ-substituted proline derivatives on the performance of the peptidic catalyst H-dPro-pro-Glu-NH2 T Schnitzer, H Wennemers Synthesis 50 (22), 4377-4382, 2018 | 16 | 2018 |
| Marine Sponge Endosymbionts: Structural and Functional Specificity of the Microbiome within Euryspongia arenaria Cells Q Yang, JKB Cahn, J Piel, YF Song, W Zhang, HW Lin Microbiology Spectrum 10 (3), e02296-21, 2022 | 11 | 2022 |
| The impact of cryosolution thermal contraction on proteins and protein crystals: volumes, conformation and order DH Juers, CA Farley, CP Saxby, RA Cotter, JKB Cahn, RC Holton-Burke, ... Acta Crystallographica Section D: Structural Biology 74 (9), 922-938, 2018 | 10 | 2018 |
| Characterization of an orphan type III polyketide synthase conserved in uncultivated “Entotheonella” sponge symbionts S Reiter, JKB Cahn, V Wiebach, R Ueoka, J Piel ChemBioChem 21 (4), 564-571, 2020 | 9 | 2020 |
Frances ArnoldProfessor of chemical engineering, CaltechBestätigte E-Mail-Adresse bei cheme.caltech.edu
