| Quantitative reactivity profiling predicts functional cysteines in proteomes E Weerapana, C Wang, GM Simon, F Richter, S Khare, MBD Dillon, ... Nature 468 (7325), 790-795, 2010 | 1582 | 2010 |
| Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages CY Taabazuing, MC Okondo, DA Bachovchin Cell chemical biology 24 (4), 507-514. e4, 2017 | 492 | 2017 |
| Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening DA Bachovchin, T Ji, W Li, GM Simon, JL Blankman, A Adibekian, ... Proceedings of the National Academy of Sciences 107 (49), 20941-20946, 2010 | 302 | 2010 |
| The pharmacological landscape and therapeutic potential of serine hydrolases DA Bachovchin, BF Cravatt Nature reviews Drug discovery 11 (1), 52-68, 2012 | 298 | 2012 |
| DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia DC Johnson, CY Taabazuing, MC Okondo, AJ Chui, SD Rao, FC Brown, ... Nature medicine 24 (8), 1151-1156, 2018 | 289 | 2018 |
| Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors A Adibekian, BR Martin, C Wang, KL Hsu, DA Bachovchin, S Niessen, ... Nature chemical biology 7 (7), 469-478, 2011 | 272 | 2011 |
| Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes DA Bachovchin, SJ Brown, H Rosen, BF Cravatt Nature biotechnology 27 (4), 387-394, 2009 | 263 | 2009 |
| N-terminal degradation activates the NLRP1B inflammasome AJ Chui, MC Okondo, SD Rao, K Gai, AR Griswold, DC Johnson, DP Ball, ... Science 364 (6435), 82-85, 2019 | 254 | 2019 |
| DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis MC Okondo, DC Johnson, R Sridharan, EB Go, AJ Chui, MS Wang, ... Nature chemical biology 13 (1), 46-53, 2017 | 240 | 2017 |
| Inhibition of Dpp8/9 activates the Nlrp1b inflammasome MC Okondo, SD Rao, CY Taabazuing, AJ Chui, SE Poplawski, ... Cell chemical biology 25 (3), 262-267. e5, 2018 | 173 | 2018 |
| LACTB is a tumour suppressor that modulates lipid metabolism and cell state Z Keckesova, JL Donaher, J De Cock, E Freinkman, S Lingrell, ... Nature 543 (7647), 681-686, 2017 | 151 | 2017 |
| Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes A Adibekian, BR Martin, JW Chang, KL Hsu, K Tsuboi, DA Bachovchin, ... Journal of the American Chemical Society 134 (25), 10345-10348, 2012 | 137 | 2012 |
| DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation LR Hollingsworth, H Sharif, AR Griswold, P Fontana, J Mintseris, ... Nature 592 (7856), 778-783, 2021 | 129 | 2021 |
| Hydrocarbon Oxidation vs C− C Bond-Forming Approaches for Efficient Syntheses of Oxygenated Molecules KJ Fraunhoffer, DA Bachovchin, MC White Organic Letters 7 (2), 223-226, 2005 | 124 | 2005 |
| Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors DA Bachovchin, JT Mohr, AE Speers, C Wang, JM Berlin, TP Spicer, ... Proceedings of the National Academy of Sciences 108 (17), 6811-6816, 2011 | 123 | 2011 |
| The NLRP1 and CARD8 inflammasomes CY Taabazuing, AR Griswold, DA Bachovchin Immunological reviews 297 (1), 13-25, 2020 | 117 | 2020 |
| Caspase-1 interdomain linker cleavage is required for pyroptosis DP Ball, CY Taabazuing, AR Griswold, EL Orth, SD Rao, IB Kotliar, ... Life science alliance 3 (3), 2020 | 105 | 2020 |
| A fluopol-ABPP HTS assay to identify PAD inhibitors B Knuckley, JE Jones, DA Bachovchin, J Slack, CP Causey, SJ Brown, ... Chemical communications 46 (38), 7175-7177, 2010 | 102 | 2010 |
| Potent and Selective Inhibitors of Glutathione S-Transferase Omega 1 That Impair Cancer Drug Resistance K Tsuboi, DA Bachovchin, AE Speers, TP Spicer, V Fernandez-Vega, ... Journal of the American Chemical Society 133 (41), 16605-16616, 2011 | 98 | 2011 |
| Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1 DA Bachovchin, AM Zuhl, AE Speers, MR Wolfe, E Weerapana, SJ Brown, ... Journal of medicinal chemistry 54 (14), 5229-5236, 2011 | 90 | 2011 |
