Mikael Elofsson
Mikael Elofsson
Professor and Dean, Department of Chemistry, Faculty of Science and Technology, Umeå University
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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity
L Meng, R Mohan, BHB Kwok, M Elofsson, N Sin, CM Crews
Proceedings of the National Academy of Sciences 96 (18), 10403-10408, 1999
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase
BHB Kwok, B Koh, MKI Ndubuisi, M Elofsson, CM Crews
Chemistry & biology 8 (8), 759-766, 2001
Targeting bacterial virulence: inhibitors of type III secretion in Yersinia
AM Kauppi, R Nordfelth, H Uvell, H Wolf-Watz, M Elofsson
Chemistry & biology 10 (3), 241-249, 2003
Total synthesis of the-potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology
N Sin, KB Kim, M Elofsson, L Meng, H Auth, BHB Kwok, CM Crews
Bioorganic & medicinal chemistry letters 9 (15), 2283-2288, 1999
Small-molecule inhibitors specifically targeting type III secretion
R Nordfelth, AM Kauppi, HA Norberg, H Wolf-Watz, M Elofsson
Infection and immunity 73 (5), 3104-3114, 2005
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis
S Muschiol, L Bailey, Å Gylfe, C Sundin, K Hultenby, S Bergström, ...
Proceedings of the National Academy of Sciences 103 (39), 14566-14571, 2006
Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram‐negative bacteria
P Keyser, M Elofsson, S Rosell, H Wolf‐Watz
Journal of internal medicine 264 (1), 17-29, 2008
Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide α', β'-epoxyketones
M Elofsson, U Splittgerber, J Myung, R Mohan, CM Crews
Chemistry & Biology 6 (11), 811-822, 1999
Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors
DL Hudson, AN Layton, TR Field, AJ Bowen, H Wolf-Watz, M Elofsson, ...
Antimicrobial agents and chemotherapy 51 (7), 2631-2635, 2007
Derivatization procedures for reducing oligosaccharides, part 3: preparation of oligosaccharide glycosylamines, and their conversion into glycosaccharide-acrylamide copolymers
E Kallin, H Lönn, T Norberg, M Elofsson
Journal of Carbohydrate Chemistry 8 (4), 597-611, 1989
Salicylidene Acylhydrazides That Affect Type III Protein Secretion in Salmonella enterica Serovar Typhimurium
A Negrea, E Bjur, SE Ygberg, M Elofsson, H Wolf-Watz, M Rhen
Antimicrobial agents and chemotherapy 51 (8), 2867-2876, 2007
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
L Bailey, Å Gylfe, C Sundin, S Muschiol, M Elofsson, P Nordström, ...
FEBS letters 581 (4), 587-595, 2007
Glycopeptides bind MHC molecules and elicit specific T cell responses.
CV Harding, J Kihlberg, M Elofsson, G Magnusson, ER Unanue
Journal of immunology (Baltimore, Md.: 1950) 151 (5), 2419-2425, 1993
Preparation of building blocks for glycopeptide synthesis by glycosylation of Fmoc amino acids having unprotected carboxyl groups
LA Salvador, M Elofsson, J Kihlberg
Tetrahedron 51 (19), 5643-5656, 1995
Removal of acyl protective groups from glycopeptides: Base does not epimerize peptide stereocenters, and β-elimination is slow
P Sjölin, M Elofsson, J Kihlberg
The Journal of organic chemistry 61 (2), 560-565, 1996
Building blocks for glycopeptide synthesis: glycosylation of 3-mercaptopropionic acid and Fmoc amino acids with unprotected carboxyl groups
M Elofsson, B Walse, J Kihlberg
Tetrahedron letters 32 (51), 7613-7616, 1991
Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds
D Wang, CE Zetterström, M Gabrielsen, KSH Beckham, JJ Tree, ...
Journal of Biological Chemistry 286 (34), 29922-29931, 2011
Reversal of the antichlamydial activity of putative type III secretion inhibitors by iron
A Slepenkin, PA Enquist, U Hägglund, LM de la Maza, M Elofsson, ...
Infection and immunity 75 (7), 3478-3489, 2007
Design, Synthesis, and Multivariate Quantitative Structure−Activity Relationship of SalicylanilidesPotent Inhibitors of Type III Secretion in Yersinia
MK Dahlgren, AM Kauppi, IM Olsson, A Linusson, M Elofsson
Journal of medicinal chemistry 50 (24), 6177-6188, 2007
Preparation of Tn and sialyl Tn building blocks used in Fmoc solid-phase synthesis of glycopeptide fragments from HIV gp120
M Elofsson, LA Salvador, J Kihlberg
Tetrahedron 53 (1), 369-390, 1997
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