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Joseph D. Bauman
Joseph D. Bauman
Amicus Therapeutics
Bestätigte E-Mail-Adresse bei amicusrx.com
Titel
Zitiert von
Zitiert von
Jahr
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations
K Das, JD Bauman, AD Clark Jr, YV Frenkel, PJ Lewi, AJ Shatkin, ...
Proceedings of the National Academy of Sciences 105 (5), 1466-1471, 2008
4012008
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism
K Das, SE Martinez, JD Bauman, E Arnold
Nature structural & molecular biology 19 (2), 253-259, 2012
1932012
Structure of HIV-1 reverse transcriptase with the inhibitor β-thujaplicinol bound at the RNase H active site
DM Himmel, KA Maegley, TA Pauly, JD Bauman, K Das, C Dharia, ...
Structure 17 (12), 1625-1635, 2009
1592009
Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase
C Fang, JD Bauman, K Das, A Remorino, E Arnold, RM Hochstrasser
Proceedings of the National Academy of Sciences 105 (5), 1472-1477, 2008
1552008
Structural basis of HIV-1 resistance to AZT by excision
X Tu, K Das, Q Han, JD Bauman, AD Clark Jr, X Hou, YV Frenkel, ...
Nature structural & molecular biology 17 (10), 1202-1209, 2010
1422010
Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase
DG Kuroda, JD Bauman, JR Challa, D Patel, T Troxler, K Das, E Arnold, ...
Nature chemistry 5 (3), 174-181, 2013
1072013
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design
JD Bauman, K Das, WC Ho, M Baweja, DM Himmel, AD Clark, DA Oren, ...
Nucleic acids research 36 (15), 5083-5092, 2008
1052008
Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery
D Patel, JD Bauman, E Arnold
Progress in biophysics and molecular biology 116 (2-3), 92-100, 2014
992014
Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors
JD Bauman, D Patel, SF Baker, RSK Vijayan, A Xiang, AK Parhi, ...
ACS chemical biology 8 (11), 2501-2508, 2013
962013
Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening
JD Bauman, D Patel, C Dharia, MW Fromer, S Ahmed, Y Frenkel, ...
Journal of medicinal chemistry 56 (7), 2738-2746, 2013
922013
Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H
S Chung, DM Himmel, JK Jiang, K Wojtak, JD Bauman, JW Rausch, ...
Journal of medicinal chemistry 54 (13), 4462-4473, 2011
902011
Pokeweed antiviral protein binds to the cap structure of eukaryotic mRNA and depurinates the mRNA downstream of the cap
KA Hudak, JD Bauman, NE Tumer
Rna 8 (9), 1148-1159, 2002
842002
Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic …
K Das, JD Bauman, AS Rim, C Dharia, AD Clark Jr, MJ Camarasa, ...
Journal of medicinal chemistry 54 (8), 2727-2737, 2011
822011
Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease
HY Sagong, JD Bauman, D Patel, K Das, E Arnold, EJ LaVoie
Journal of medicinal chemistry 57 (19), 8086-8098, 2014
652014
3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease
HY Sagong, A Parhi, JD Bauman, D Patel, RSK Vijayan, K Das, E Arnold, ...
ACS medicinal chemistry letters 4 (6), 547-550, 2013
612013
Structure of the guanylyltransferase domain of human mRNA capping enzyme
C Chu, K Das, JR Tyminski, JD Bauman, R Guan, W Qiu, GT Montelione, ...
Proceedings of the National Academy of Sciences 108 (25), 10104-10108, 2011
522011
A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants
BC Johnson, GT Pauly, G Rai, D Patel, JD Bauman, HL Baker, K Das, ...
Retrovirology 9, 1-11, 2012
472012
Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies
AK Felts, K LaBarge, JD Bauman, DV Patel, DM Himmel, E Arnold, ...
Journal of chemical information and modeling 51 (8), 1986-1998, 2011
442011
Phenyl substituted 3-hydroxypyridin-2 (1H)-ones: inhibitors of influenza A endonuclease
AK Parhi, A Xiang, JD Bauman, D Patel, RSK Vijayan, K Das, E Arnold, ...
Bioorganic & medicinal chemistry 21 (21), 6435-6446, 2013
422013
Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility
M Bollini, KM Frey, JA Cisneros, KA Spasov, K Das, JD Bauman, E Arnold, ...
Bioorganic & medicinal chemistry letters 23 (18), 5209-5212, 2013
392013
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