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David A. Pirman
David A. Pirman
Director, Agios
Bestätigte E-Mail-Adresse bei agios.com
Titel
Zitiert von
Zitiert von
Jahr
Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard
DA Pirman, RF Reich, A Kiss, RMA Heeren, RA Yost
Analytical chemistry 85 (2), 1081-1089, 2013
1832013
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Nature 547, 109-113, 2017
1792017
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
AK Padyana, S Gross, L Jin, G Cianchetta, R Narayanaswamy, F Wang, ...
Nature communications 10 (1), 97, 2019
1032019
Quantitative tandem mass spectrometric imaging of endogenous acetyl-L-carnitine from piglet brain tissue using an internal standard
DA Pirman, RA Yost
Analytical chemistry 83 (22), 8575-8581, 2011
882011
Recurrent germline DLST mutations in individuals with multiple pheochromocytomas and paragangliomas
L Remacha, D Pirman, CE Mahoney, J Coloma, B Calsina, ...
The American Journal of Human Genetics 104 (4), 651-664, 2019
852019
Identifying tissue-specific signal variation in MALDI mass spectrometric imaging by use of an internal standard
DA Pirman, A Kiss, RMA Heeren, RA Yost
Analytical chemistry 85 (2), 1090-1096, 2013
842013
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
CE Mahoney, D Pirman, V Chubukov, T Sleger, S Hayes, ZP Fan, ...
Nature communications 10 (1), 96, 2019
702019
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH
Cell Reports 17 (3), 876-890, 2016
672016
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer
SA Best, PM Gubser, S Sethumadhavan, A Kersbergen, YLN Abril, ...
Cell Metabolism 34 (6), 874-887. e6, 2022
612022
Targeting hepatic glutaminase activity to ameliorate hyperglycemia
RA Miller, Y Shi, W Lu, DA Pirman, A Jatkar, M Blatnik, H Wu, C Cárdenas, ...
Nature medicine 24 (4), 518-524, 2018
612018
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
K Huard, J Brown, JC Jones, S Cabral, K Futatsugi, M Gorgoglione, ...
Scientific reports 5 (1), 17391, 2015
612015
Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry
DA Pirman, E Efuet, XP Ding, Y Pan, L Tan, SM Fischer, RN DuBois, ...
PloS one 8 (4), e61379, 2013
432013
Preclinical toxicology profile of squalene epoxidase inhibitors
R Nagaraja, A Olaharski, R Narayanaswamy, C Mahoney, D Pirman, ...
Toxicology and Applied Pharmacology 401, 115103, 2020
162020
Quantitative profiling of tissue drug distribution by MS imaging
D Pirman
Bioanalysis 7 (20), 2649-2656, 2015
122015
Metabolic analysis reveals evidence for branched chain amino acid catabolism crosstalk and the potential for improved treatment of organic acidurias
S McCalley, D Pirman, M Clasquin, K Johnson, S Jin, J Vockley
Molecular genetics and metabolism 128 (1-2), 57-61, 2019
112019
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun 10: 97
AK Padyana, S Gross, L Jin, G Cianchetta, R Narayanaswamy, F Wang, ...
112019
Phenotyping hepatocellular metabolism using uniformly labeled carbon-13 molecular probes and LC-HRMS stable isotope tracing
JK Meissen, DA Pirman, M Wan, E Miller, A Jatkar, R Miller, RC Steenwyk, ...
Analytical Biochemistry 508, 129-137, 2016
112016
Correction: Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
A Zabala-Letona, A Arruabarrena-Aristorena, N Martín-Martín, ...
Nature 554 (7693), 554-554, 2018
82018
Plasma concentration and local anesthetic activity of procaine hydrochloride following subcutaneous administration to horses
NL Kuchembuck, PT Colahan, KD Zientek, DA Pirman, K Wegner, ...
American journal of veterinary research 68 (5), 495-500, 2007
82007
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux
SN Masud, M Chandrashekhar, M Aregger, G Tan, X Zhang, P Mero, ...
Nature Chemical Biology 18 (12), 1370-1379, 2022
32022
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