Jose M. Orozco
Jose M. Orozco
Hanna H. Gray Fellow, Dana-Farber Cancer Institute, Harvard Medical School
Verified email at
Cited by
Cited by
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
SCJ Parker, ML Stitzel, DL Taylor, JM Orozco, MR Erdos, JA Akiyama, ...
Proceedings of the National Academy of Sciences 110 (44), 17921-17926, 2013
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
X Gu, JM Orozco, RA Saxton, KJ Condon, GY Liu, PA Krawczyk, ...
Science 358 (6364), 813-818, 2017
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
L Chantranupong, RL Wolfson, JM Orozco, RA Saxton, SM Scaria, ...
Cell reports 9 (1), 1-8, 2014
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
RL Wolfson, L Chantranupong, GA Wyant, X Gu, JM Orozco, K Shen, ...
Nature 543 (7645), 438-442, 2017
Dihydroxyacetone phosphate signals glucose availability to mTORC1
JM Orozco, PA Krawczyk, SM Scaria, AL Cangelosi, SH Chan, T Kunchok, ...
Nature metabolism 2 (9), 893-901, 2020
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
KJ Condon, JM Orozco, CH Adelmann, JB Spinelli, PW van der Helm, ...
Proceedings of the National Academy of Sciences 118 (4), e2022120118, 2021
Filamin and Phospholipase C-ε Are Required for Calcium Signaling in the Caenorhabditis elegans Spermatheca
I Kovacevic, JM Orozco, EJ Cram
PLoS genetics 9 (5), e1003510, 2013
The methionine transamination pathway controls hepatic glucose metabolism through regulation of the GCN5 acetyltransferase and the PGC-1α transcriptional coactivator
CDJ Tavares, K Sharabi, JE Dominy, Y Lee, M Isasa, JM Orozco, ...
Journal of Biological Chemistry 291 (20), 10635-10645, 2016
Methods of identifying modulators of sestrin-gator-2 interaction for modulating mTORC1 activity
DM Sabatini, L Chantranupong, RL Wolfson, J Orozco, RA Saxton, ...
US Patent 10,168,338, 2019
Methods of identifying modulators of SAMTOR-GATOR1 interaction and use of same to modulate mTORC1
DM Sabatini, X Gu, JM Orozco
US Patent 11,499,981, 2022
Signal transduction in human cells by metabolites derived from methionine and glucose
JM Orozco
Massachusetts Institute of Technology, 2021
The system can't perform the operation now. Try again later.
Articles 1–11