| Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design RA Chica, N Doucet, JN Pelletier Current opinion in biotechnology 16 (4), 378-384, 2005 | 717 | 2005 |
| Iterative approach to computational enzyme design HK Privett, G Kiss, TM Lee, R Blomberg, RA Chica, LM Thomas, D Hilvert, ... Proceedings of the National Academy of Sciences 109 (10), 3790-3795, 2012 | 377 | 2012 |
| Generation of longer emission wavelength red fluorescent proteins using computationally designed libraries RA Chica, MM Moore, BD Allen, SL Mayo Proceedings of the National Academy of Sciences 107 (47), 20257-20262, 2010 | 135 | 2010 |
| Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico A Broom, RV Rakotoharisoa, MC Thompson, N Zarifi, E Nguyen, ... Nature Communications 11 (1), 1-10, 2020 | 91* | 2020 |
| Rational design of proteins that exchange on functional timescales JA Davey, AM Damry, NK Goto, RA Chica Nature chemical biology 13 (12), 1280-1285, 2017 | 88 | 2017 |
| Multistate approaches in computational protein design JA Davey, RA Chica Protein Science 21 (9), 1241-1252, 2012 | 86 | 2012 |
| The bioorganic chemistry of transglutaminase—from mechanism to inhibition and engineering JW Keillor, RA Chica, N Chabot, V Vinci, C Pardin, E Fortin, SMFG Gillet, ... Canadian Journal of Chemistry 86 (4), 271-276, 2008 | 57 | 2008 |
| Tissue transglutaminase acylation: Proposed role of conserved active site Tyr and Trp residues revealed by molecular modeling of peptide substrate binding RA Chica, P Gagnon, JW Keillor, JN Pelletier Protein Science 13 (4), 979-991, 2004 | 54 | 2004 |
| ProtaBank: A repository for protein design and engineering data CY Wang, PM Chang, ML Ary, BD Allen, RA Chica, SL Mayo, BD Olafson Protein Science 27 (6), 1113-1124, 2018 | 53 | 2018 |
| Improving the accuracy of protein stability predictions with multistate design using a variety of backbone ensembles JA Davey, RA Chica Proteins: Structure, Function, and Bioinformatics 82 (5), 771-784, 2014 | 52 | 2014 |
| One-Pot Biocatalytic Synthesis of Substituted d-Tryptophans from Indoles Enabled by an Engineered Aminotransferase F Parmeggiani, A Rué Casamajo, CJW Walton, JL Galman, NJ Turner, ... ACS Catalysis 9 (4), 3482-3486, 2019 | 51 | 2019 |
| Recovery of red fluorescent protein chromophore maturation deficiency through rational design MM Moore, SK Oteng-Pabi, AT Pandelieva, SL Mayo, RA Chica PloS one 7 (12), e52463, 2012 | 40 | 2012 |
| Discovery of substrates for a SET domain lysine methyltransferase predicted by multistate computational protein design S Lanouette, JA Davey, F Elisma, Z Ning, D Figeys, RA Chica, JF Couture Structure 23 (1), 206-215, 2015 | 39 | 2015 |
| Brighter red fluorescent proteins by rational design of triple-decker motif AT Pandelieva, MJ Baran, GF Calderini, JL McCann, V Tremblay, ... ACS chemical biology 11 (2), 508-517, 2016 | 34 | 2016 |
| Computational design of multisubstrate enzyme specificity AD St-Jacques, MEC Eyahpaise, RA Chica Acs Catalysis 9 (6), 5480-5485, 2019 | 31 | 2019 |
| Engineered Aminotransferase for the Production of d‐Phenylalanine Derivatives Using Biocatalytic Cascades CJW Walton, F Parmeggiani, JEB Barber, JL McCann, NJ Turner, ... ChemCatChem 10 (2), 470-474, 2018 | 31 | 2018 |
| Expression and rapid purification of highly active hexahistidine-tagged guinea pig liver transglutaminase SMFG Gillet, RA Chica, JW Keillor, JN Pelletier Protein expression and purification 33 (2), 256-264, 2004 | 31 | 2004 |
| Protein engineering in the 21st century RA Chica Protein science: a publication of the Protein Society 24 (4), 431, 2015 | 30 | 2015 |
| Photolabeling of tissue transglutaminase reveals the binding mode of potent cinnamoyl inhibitors C Pardin, I Roy, RA Chica, E Bonneil, P Thibault, WD Lubell, JN Pelletier, ... Biochemistry 48 (15), 3346-3353, 2009 | 30 | 2009 |
| Structure-guided rational design of red fluorescent proteins: towards designer genetically-encoded fluorophores MG Eason, AM Damry, RA Chica Current opinion in structural biology 45, 91-99, 2017 | 29 | 2017 |
Nicolas DoucetCentre Armand-Frappier Santé Biotechnologie, INRS, Université du QuébecVerified email at inrs.ca
