Adrian Isaacs
Adrian Isaacs
UCL Institute of Neurology
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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
M Hutton, CL Lendon, P Rizzu, M Baker, S Froelich, H Houlden, ...
Nature 393 (6686), 702-705, 1998
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
PM Nolan, J Peters, M Strivens, D Rogers, J Hagan, N Spurr, IC Gray, ...
Nature genetics 25 (4), 440-443, 2000
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
M Filimonenko, S Stuffers, C Raiborg, A Yamamoto, L Malerřd, ...
The Journal of cell biology 179 (3), 485-500, 2007
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
S Mizielinska, S Grönke, T Niccoli, CE Ridler, EL Clayton, A Devoy, ...
Science 345 (6201), 1192-1194, 2014
The heritability and genetics of frontotemporal lobar degeneration
JD Rohrer, R Guerreiro, J Vandrovcova, J Uphill, D Reiman, J Beck, ...
Neurology 73 (18), 1451-1456, 2009
Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population
J Beck, M Poulter, D Hensman, JD Rohrer, CJ Mahoney, G Adamson, ...
The American Journal of Human Genetics 92 (3), 345-353, 2013
Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
JD Rohrer, T Lashley, JM Schott, JE Warren, S Mead, AM Isaacs, J Beck, ...
Brain 134 (9), 2565-2581, 2011
C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes
P Fratta, S Mizielinska, AJ Nicoll, M Zloh, EMC Fisher, G Parkinson, ...
Scientific reports 2 (1), 1-6, 2012
Evolution of the aging brain transcriptome and synaptic regulation
PM Loerch, T Lu, KA Dakin, JM Vann, A Isaacs, C Geula, J Wang, Y Pan, ...
PloS one 3 (10), e3329, 2008
C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci
S Mizielinska, T Lashley, FE Norona, EL Clayton, CE Ridler, P Fratta, ...
Acta neuropathologica 126 (6), 845-857, 2013
FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration
H Urwin, KA Josephs, JD Rohrer, IR Mackenzie, M Neumann, A Authier, ...
Acta neuropathologica 120 (1), 33-41, 2010
A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series
J Beck, JD Rohrer, T Campbell, A Isaacs, KE Morrison, EF Goodall, ...
Brain 131 (3), 706-720, 2008
C9orf72-mediated ALS and FTD: multiple pathways to disease
R Balendra, AM Isaacs
Nature Reviews Neurology 14 (9), 544-558, 2018
C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis
JD Rohrer, AM Isaacs, S Mizielinska, S Mead, T Lashley, S Wray, K Sidle, ...
The Lancet Neurology 14 (3), 291-301, 2015
Conformation determines the seeding potencies of native and recombinant Tau aggregates
B Falcon, A Cavallini, R Angers, S Glover, TK Murray, L Barnham, ...
Journal of biological chemistry 290 (2), 1049-1065, 2015
Acceleration of amyloid β-peptide aggregation by physiological concentrations of calcium
AM Isaacs, DB Senn, M Yuan, JP Shine, BA Yankner
Journal of biological chemistry 281 (38), 27916-27923, 2006
Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations
H Urwin, A Authier, JE Nielsen, D Metcalf, C Powell, K Froud, DS Malcolm, ...
Human molecular genetics 19 (11), 2228-2238, 2010
G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome
R Simone, P Fratta, S Neidle, GN Parkinson, AM Isaacs
FEBS letters 589 (14), 1653-1668, 2015
CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro
J van der Zee, H Urwin, S Engelborghs, M Bruyland, R Vandenberghe, ...
Human molecular genetics 17 (2), 313-322, 2008
Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia
P Fratta, M Poulter, T Lashley, JD Rohrer, JM Polke, J Beck, N Ryan, ...
Acta neuropathologica 126 (3), 401-409, 2013
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