Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance J Zhang, X Bu, H Wang, Y Zhu, Y Geng, NT Nihira, Y Tan, Y Ci, F Wu, ... Nature 553 (7686), 91-95, 2018 | 777 | 2018 |
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex P Liu, W Gan, YR Chin, K Ogura, J Guo, J Zhang, B Wang, J Blenis, ... Cancer discovery 5 (11), 1194-1209, 2015 | 398 | 2015 |
Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 X Dai, W Gan, X Li, S Wang, W Zhang, L Huang, S Liu, Q Zhong, J Guo, ... Nature medicine 23 (9), 1063-1071, 2017 | 280 | 2017 |
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner J Guo, AA Chakraborty, P Liu, W Gan, X Zheng, H Inuzuka, B Wang, ... Science 353 (6302), 929-932, 2016 | 181 | 2016 |
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling B Wang, Z Jie, D Joo, A Ordureau, P Liu, W Gan, J Guo, J Zhang, BJ North, ... Nature 545 (7654), 365-369, 2017 | 154 | 2017 |
Analysis of PD1, PDL1, PDL2 expression and T cells infiltration in 1014 gastric cancer patients X Xing, J Guo, G Ding, B Li, B Dong, Q Feng, S Li, J Zhang, X Ying, ... Oncoimmunology 7 (3), e1356144, 2018 | 133 | 2018 |
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions J Guo, X Dai, B Laurent, N Zheng, W Gan, J Zhang, A Guo, M Yuan, P Liu, ... Nature cell biology 21 (2), 226-237, 2019 | 114 | 2019 |
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade X Dai, X Bu, Y Gao, J Guo, J Hu, C Jiang, Z Zhang, K Xu, J Duan, S He, ... Molecular cell 81 (11), 2317-2331. e6, 2021 | 113 | 2021 |
The emerging roles of protein homeostasis‐governing pathways in Alzheimer's disease J Cheng, BJ North, T Zhang, X Dai, K Tao, J Guo, W Wei Aging cell 17 (5), e12801, 2018 | 105 | 2018 |
Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt J Zhang, K Xu, P Liu, Y Geng, B Wang, W Gan, J Guo, F Wu, YR Chin, ... Molecular cell 62 (6), 929-942, 2016 | 104 | 2016 |
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis Z Sun, Q Jiang, J Li, J Guo Signal transduction and targeted therapy 5 (1), 150, 2020 | 90 | 2020 |
Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner J Guo, J Cheng, N Zheng, X Zhang, X Dai, L Zhang, C Hu, X Wu, Q Jiang, ... Advanced science 8 (18), 2004303, 2021 | 80 | 2021 |
Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair P Liu, W Gan, C Guo, A Xie, D Gao, J Guo, J Zhang, N Willis, A Su, ... Molecular cell 57 (4), 648-661, 2015 | 75 | 2015 |
Functional analysis of Cullin 3 E3 ligases in tumorigenesis J Cheng, J Guo, Z Wang, BJ North, K Tao, X Dai, W Wei Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1869 (1), 11-28, 2018 | 69 | 2018 |
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control W Gan, X Dai, X Dai, J Xie, S Yin, J Zhu, C Wang, Y Liu, J Guo, M Wang, ... Nature cell biology 22 (2), 246-256, 2020 | 68 | 2020 |
New insights into protein hydroxylation and its important role in human diseases G Zurlo, J Guo, M Takada, W Wei, Q Zhang Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1866 (2), 208-220, 2016 | 64 | 2016 |
Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle J Liu, Y Peng, LE Shi, L Wan, H Inuzuka, J Long, J Guo, J Zhang, M Yuan, ... Cell research 31 (1), 80-93, 2021 | 60 | 2021 |
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology J Guo, J Cheng, BJ North, W Wei Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1868 (2), 341-358, 2017 | 59 | 2017 |
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells L Zhang, S Peng, X Dai, W Gan, X Nie, W Wei, G Hu, J Guo Cancer letters 390, 11-20, 2017 | 55 | 2017 |
The emerging role for Cullin 4 family of E3 ligases in tumorigenesis J Cheng, J Guo, BJ North, K Tao, P Zhou, W Wei Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1871 (1), 138-159, 2019 | 54 | 2019 |