Simon Warby
Zitiert von
Zitiert von
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
RK Graham, Y Deng, EJ Slow, B Haigh, N Bissada, G Lu, J Pearson, ...
Cell 125 (6), 1179-1191, 2006
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
F Han, L Lin, SC Warby, J Faraco, J Li, SX Dong, P An, L Zhao, LH Wang, ...
Annals of neurology 70 (3), 410-417, 2011
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ...
Journal of Neuroscience 22 (18), 7862-7872, 2002
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
JM Lee, EM Ramos, JH Lee, T Gillis, JS Mysore, MR Hayden, SC Warby, ...
Neurology 78 (10), 690-695, 2012
Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods
SC Warby, SL Wendt, P Welinder, EGS Munk, O Carrillo, HBD Sorensen, ...
Nature methods 11 (4), 385, 2014
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the huntington disease gene/allele-specific silencing of mutant Huntingtin
JB Carroll, SC Warby, AL Southwell, CN Doty, S Greenlee, N Skotte, ...
Molecular Therapy 19 (12), 2178-2185, 2011
CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup
SC Warby, A Montpetit, AR Hayden, JB Carroll, SL Butland, H Visscher, ...
The American Journal of Human Genetics 84 (3), 351-366, 2009
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis
RR Singaraja, S Hadano, M Metzler, S Givan, CL Wellington, S Warby, ...
Human molecular genetics 11 (23), 2815-2828, 2002
Common variants in P2RY11 are associated with narcolepsy
BR Kornum, M Kawashima, J Faraco, L Lin, TJ Rico, S Hesselson, ...
Nature genetics 43 (1), 66-71, 2011
HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia
SC Warby, H Visscher, JA Collins, CN Doty, C Carter, SL Butland, ...
European Journal of Human Genetics 19 (5), 561-566, 2011
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo
SC Warby, EY Chan, M Metzler, L Gan, RR Singaraja, SF Crocker, ...
Human molecular genetics 14 (11), 1569-1577, 2005
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain
AS Hackam, AS Yassa, R Singaraja, M Metzler, CA Gutekunst, L Gan, ...
Journal of Biological Chemistry 275 (52), 41299-41308, 2000
Predictive testing for Huntington disease: interpretation and significance of intermediate alleles
A Semaka, S Creighton, S Warby, MR Hayden
Clinical genetics 70 (4), 283-294, 2006
Huntington disease
SC Warby, RK Graham, MR Hayden
GeneReviews at GeneTests: Medical Genetics Information Resource (database …, 2010
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
SC Warby, CN Doty, RK Graham, JB Carroll, YZ Yang, RR Singaraja, ...
Human molecular genetics 17 (15), 2390-2404, 2008
Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients
NH Skotte, AL Southwell, ME Østergaard, JB Carroll, SC Warby, CN Doty, ...
PloS one 9 (9), e107434, 2014
Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study
DJ Gottlieb, K Hek, TH Chen, NF Watson, G Eiriksdottir, EM Byrne, ...
Molecular psychiatry 20 (10), 1232-1239, 2015
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments
SC Warby, CN Doty, RK Graham, J Shively, RR Singaraja, MR Hayden
Molecular and Cellular Neuroscience 40 (2), 121-127, 2009
A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease
K Bečanović, A Nørremølle, SJ Neal, C Kay, JA Collins, D Arenillas, T Lilja, ...
Nature neuroscience 18 (6), 807-816, 2015
A fully humanized transgenic mouse model of Huntington disease
AL Southwell, SC Warby, JB Carroll, CN Doty, NH Skotte, W Zhang, ...
Human Molecular Genetics 22 (1), 18-34, 2013
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