| Drugs for bad bugs: confronting the challenges of antibacterial discovery DJ Payne, MN Gwynn, DJ Holmes, DL Pompliano Nature reviews Drug discovery 6 (1), 29-40, 2007 | 2904 | 2007 |
| Drug–target residence time and its implications for lead optimization RA Copeland, DL Pompliano, TD Meek Nature reviews Drug discovery 5 (9), 730-739, 2006 | 1553 | 2006 |
| Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor NE Kohl, SD Mosser, SJ DeSolms, EA Giuliani, DL Pompliano, ... Science 260 (5116), 1934-1937, 1993 | 851 | 1993 |
| Sequence dependence of protein isoprenylation SL Moores, MD Schaber, SD Mosser, E Rands, MB O'Hara, VM Garsky, ... Journal of Biological Chemistry 266 (22), 14603-14610, 1991 | 764 | 1991 |
| Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. JB Gibbs, DL Pompliano, SD Mosser, E Rands, RB Lingham, SB Singh, ... Journal of Biological Chemistry 268 (11), 7617-7620, 1993 | 408 | 1993 |
| Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase DL Pompliano, A Peyman, JR Knowles Biochemistry 29 (13), 3186-3194, 1990 | 382 | 1990 |
| Steady-state kinetic mechanism of Ras farnesyl: protein transferase DL Pompliano, E Rands, MD Schaber, SD Mosser, NJ Anthony, JB Gibbs Biochemistry 31 (15), 3800-3807, 1992 | 376 | 1992 |
| Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamase JH Toney, PMD Fitzgerald, N Grover-Sharma, SH Olson, WJ May, ... Chemistry & biology 5 (4), 185-196, 1998 | 309 | 1998 |
| Intramolecular fluorescence enhancement: a continuous assay of Ras farnesyl: protein transferase DL Pompliano, RP Gomez, NJ Anthony Journal of the American Chemical Society 114 (20), 7945-7946, 1992 | 182 | 1992 |
| Biocatalytic synthesis of aromatics from D-glucose: the role of transketolase KM Draths, DL Pompliano, DL Conley, JW Frost, A Berry, GL Disbrow, ... Journal of the American Chemical Society 114 (10), 3956-3962, 1992 | 180 | 1992 |
| Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-γ-glutamate ligases: identification of a … SS Eveland, DL Pompliano, MS Anderson Biochemistry 36 (20), 6223-6229, 1997 | 146 | 1997 |
| Isoprenoid diphosphate utilization by recombinant human farnesyl: protein transferase: interactive binding between substrates and a preferred kinetic pathway DL Pompliano, MD Schaber, SD Mosser, CA Omer, JA Shafer, JB Gibbs Biochemistry 32 (32), 8341-8347, 1993 | 138 | 1993 |
| Pseudopeptide inhibitors of Ras farnesyl-protein transferase SL Graham, SJ deSolms, EA Giuliani, NE Kohl, SD Mosser, AI Oliff, ... Journal of medicinal chemistry 37 (6), 725-732, 1994 | 135 | 1994 |
| An array of target-specific screening strains for antibacterial discovery JA DeVito, JA Mills, VG Liu, A Agarwal, CF Sizemore, Z Yao, ... Nature biotechnology 20 (5), 478-483, 2002 | 131 | 2002 |
| Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases. NE Kohl, RE Diehl, MD Schaber, E Rands, DD Soderman, B He, ... Journal of Biological Chemistry 266 (28), 18884-18888, 1991 | 128 | 1991 |
| Anti-infective research and development—problems, challenges, and solutions JS Bradley, R Guidos, S Baragona, JG Bartlett, E Rubinstein, GG Zhanel, ... The Lancet infectious diseases 7 (1), 68-78, 2007 | 123 | 2007 |
| Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion MS Anderson, SS Eveland, HR Onishi, DL Pompliano Biochemistry 35 (50), 16264-16269, 1996 | 115 | 1996 |
| Oxazolidinones mechanism of action: inhibition of the first peptide bond formation U Patel, YP Yan, FW Hobbs, J Kaczmarczyk, AM Slee, DL Pompliano, ... Journal of Biological Chemistry 276 (40), 37199-37205, 2001 | 103 | 2001 |
| Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-β-lactamase ML Greenlee, JB Laub, JM Balkovec, ML Hammond, GG Hammond, ... Bioorganic & medicinal chemistry letters 9 (17), 2549-2554, 1999 | 87 | 1999 |
| Degradation and detoxification of organophosphonates. Cleavage of the carbon-phosphorus bond ML Cordeiro, DL Pompliano, JW Frost Journal of the American Chemical Society 108 (2), 332-334, 1986 | 86 | 1986 |
