| Multiple high-throughput analyses monitor the response of E. coli to perturbations N Ishii, K Nakahigashi, T Baba, M Robert, T Soga, A Kanai, T Hirasawa, ... Science 316 (5824), 593-597, 2007 | 792 | 2007 |
| Systematic phenome analysis of Escherichia coli multiple‐knockout mutants reveals hidden reactions in central carbon metabolism K Nakahigashi, Y Toya, N Ishii, T Soga, M Hasegawa, H Watanabe, ... Molecular systems biology 5 (1), 306, 2009 | 194 | 2009 |
| Flux analysis and metabolomics for systematic metabolic engineering of microorganisms Y Toya, H Shimizu Biotechnology advances 31 (6), 818-826, 2013 | 138 | 2013 |
| 13C‐metabolic flux analysis for batch culture of Escherichia coli and its pyk and pgi gene knockout mutants based on mass isotopomer distribution of intracellular … Y Toya, N Ishii, K Nakahigashi, T Hirasawa, T Soga, M Tomita, K Shimizu Biotechnology progress 26 (4), 975-992, 2010 | 132 | 2010 |
| Direct measurement of isotopomer of intracellular metabolites using capillary electrophoresis time-of-flight mass spectrometry for efficient metabolic flux analysis Y Toya, N Ishii, T Hirasawa, M Naba, K Hirai, K Sugawara, S Igarashi, ... Journal of chromatography A 1159 (1-2), 134-141, 2007 | 85 | 2007 |
| Combinatorial deletions of glgC and phaCE enhance ethanol production in Synechocystis sp. PCC 6803 K Namakoshi, T Nakajima, K Yoshikawa, Y Toya, H Shimizu Journal of biotechnology 239, 13-19, 2016 | 63 | 2016 |
| Optogenetic switch for controlling the central metabolic flux of Escherichia coli ST Tandar, S Senoo, Y Toya, H Shimizu Metabolic engineering 55, 68-75, 2019 | 53 | 2019 |
| Metabolic regulation analysis of wild-type and arcA mutant Escherichia coli under nitrate conditions using different levels of omics data Y Toya, K Nakahigashi, M Tomita, K Shimizu Molecular BioSystems 8 (10), 2593-2604, 2012 | 52 | 2012 |
| Metabolic Flux Analysis of the Synechocystis sp. PCC 6803 ΔnrtABCD Mutant Reveals a Mechanism for Metabolic Adaptation to Nitrogen-Limited Conditions T Nakajima, K Yoshikawa, Y Toya, F Matsuda, H Shimizu Plant and Cell Physiology 58 (3), 537-545, 2017 | 50 | 2017 |
| 13C-metabolic flux analysis for mevalonate-producing strain of Escherichia coli K Wada, Y Toya, S Banno, K Yoshikawa, F Matsuda, H Shimizu Journal of bioscience and bioengineering 123 (2), 177-182, 2017 | 49 | 2017 |
| Metabolic engineering of Synechocystis sp. PCC 6803 for enhanced ethanol production based on flux balance analysis K Yoshikawa, Y Toya, H Shimizu Bioprocess and biosystems engineering 40, 791-796, 2017 | 48 | 2017 |
| High-yielding rice Takanari has superior photosynthetic response to a commercial rice Koshihikari under fluctuating light S Adachi, Y Tanaka, A Miyagi, M Kashima, A Tezuka, Y Toya, ... Journal of experimental botany 70 (19), 5287-5297, 2019 | 44 | 2019 |
| Metabolic flux analysis and visualization Y Toya, N Kono, K Arakawa, M Tomita Journal of proteome research 10 (8), 3313-3323, 2011 | 44 | 2011 |
| Glycogen is the primary source of glucose during the lag phase of E. coli proliferation T Yamamotoya, H Dose, Z Tian, A Fauré, Y Toya, M Honma, K Igarashi, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1824 (12), 1442-1448, 2012 | 41 | 2012 |
| Identification of alcohol stress tolerance genes of Synechocystis sp. PCC 6803 using adaptive laboratory evolution T Matsusako, Y Toya, K Yoshikawa, H Shimizu Biotechnology for biofuels 10 (1), 307, 2017 | 39 | 2017 |
| Integrating kinetic model of E. coli with genome scale metabolic fluxes overcomes its open system problem and reveals bistability in central metabolism AA Mannan, Y Toya, K Shimizu, J McFadden, AM Kierzek, A Rocco PloS one 10 (10), e0139507, 2015 | 37 | 2015 |
| 13C-metabolic flux analysis in heterologous cellulase production by Bacillus subtilis genome-reduced strain Y Toya, T Hirasawa, T Morimoto, K Masuda, Y Kageyama, K Ozaki, ... Journal of biotechnology 179, 42-49, 2014 | 37 | 2014 |
| Magnesium starvation improves production of malonyl-CoA-derived metabolites in Escherichia coli K Tokuyama, Y Toya, F Matsuda, BF Cress, MAG Koffas, H Shimizu Metabolic engineering 52, 215-223, 2019 | 35 | 2019 |
| Construction of a Genome-Scale Metabolic Model of Arthrospira platensis NIES-39 and Metabolic Design for Cyanobacterial Bioproduction K Yoshikawa, S Aikawa, Y Kojima, Y Toya, C Furusawa, A Kondo, ... PLoS One 10 (12), e0144430, 2015 | 33 | 2015 |
| Application of adaptive laboratory evolution to overcome a flux limitation in an Escherichia coli production strain K Tokuyama, Y Toya, T Horinouchi, C Furusawa, F Matsuda, H Shimizu Biotechnology and bioengineering 115 (6), 1542-1551, 2018 | 30 | 2018 |
Hiroshi ShimizuProfessor, Department of Bioinformatic Engineering, Osaka UniversityVerified email at ist.osaka-u.ac.jp
