| New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, ... Nature genetics 42 (2), 105-116, 2010 | 2493 | 2010 |
| Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA J Kettunen, A Demirkan, P Würtz, HHM Draisma, T Haller, R Rawal, ... Nature communications 7 (1), 11122, 2016 | 621 | 2016 |
| Meta-analysis of genome-wide association studies in> 80 000 subjects identifies multiple loci for C-reactive protein levels A Dehghan, J Dupuis, M Barbalic, JC Bis, G Eiriksdottir, C Lu, N Pellikka, ... Circulation 123 (7), 731-738, 2011 | 581 | 2011 |
| Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals Z Dastani, MF Hivert, N Timpson, JRB Perry, X Yuan, RA Scott, ... PLoS genetics 8 (3), e1002607, 2012 | 559 | 2012 |
| Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit Z Li, CX Yi, S Katiraei, S Kooijman, E Zhou, CK Chung, Y Gao, ... Gut 67 (7), 1269-1279, 2018 | 508 | 2018 |
| Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure LV Wain, GC Verwoert, PF O'reilly, G Shi, T Johnson, AD Johnson, ... Nature genetics 43 (10), 1005-1011, 2011 | 502 | 2011 |
| Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk FR Day, DJ Thompson, H Helgason, DI Chasman, H Finucane, P Sulem, ... Nature genetics 49 (6), 834-841, 2017 | 495 | 2017 |
| The power of genetic diversity in genome-wide association studies of lipids SE Graham, SL Clarke, KHH Wu, S Kanoni, GJM Zajac, S Ramdas, ... Nature 600 (7890), 675-679, 2021 | 392 | 2021 |
| ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis FG Schaap, PCN Rensen, PJ Voshol, C Vrins, HN van der Vliet, ... Journal of biological chemistry 279 (27), 27941-27947, 2004 | 391 | 2004 |
| The trans-ancestral genomic architecture of glycemic traits J Chen, CN Spracklen, G Marenne, A Varshney, LJ Corbin, J Luan, ... Nature genetics 53 (6), 840-860, 2021 | 369 | 2021 |
| Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis MPJ de Winther, KW van Dijk, LM Havekes, MH Hofker Arteriosclerosis, thrombosis, and vascular biology 20 (2), 290-297, 2000 | 347 | 2000 |
| Detrimental effects of constant light exposure and high‐fat diet on circadian energy metabolism and insulin sensitivity CP Coomans, SAA van den Berg, T Houben, JB van Klinken, ... The FASEB Journal 27 (4), 1721-1732, 2013 | 274 | 2013 |
| Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping PJP De Vree, E De Wit, M Yilmaz, M Van De Heijning, P Klous, ... Nature biotechnology 32 (10), 1019-1025, 2014 | 271 | 2014 |
| Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation A Mahajan, CN Spracklen, W Zhang, MCY Ng, LE Petty, H Kitajima, ... Nature genetics 54 (5), 560-572, 2022 | 270 | 2022 |
| The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study AW Visser, R De Mutsert, S Le Cessie, M Den Heijer, FR Rosendaal, ... Annals of the rheumatic diseases 74 (10), 1842-1847, 2015 | 260 | 2015 |
| Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection N de Bont, MG Netea, PNM Demacker, I Verschueren, BJ Kullberg, ... Journal of lipid research 40 (4), 680-685, 1999 | 241 | 1999 |
| Genetic insights into biological mechanisms governing human ovarian ageing KS Ruth, FR Day, J Hussain, A Martínez-Marchal, CE Aiken, A Azad, ... Nature 596 (7872), 393-397, 2021 | 212 | 2021 |
| Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice L Hussaarts, N García‐Tardón, L van Beek, MM Heemskerk, S Haeberlein, ... The FASEB Journal, 3027-3039, 2015 | 210 | 2015 |
| Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL-and HL-dependent hepatic cholesterol uptake L Lichtenstein, JFP Berbée, SJ van Dijk, KW van Dijk, A Bensadoun, ... Arteriosclerosis, thrombosis, and vascular biology 27 (11), 2420-2427, 2007 | 208 | 2007 |
| The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity CP Coomans, SAA van den Berg, EA Lucassen, T Houben, ACM Pronk, ... Diabetes 62 (4), 1102-1108, 2013 | 204 | 2013 |
