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Identification and importance of brown adipose tissue in adult humans AM Cypess, S Lehman, G Williams, I Tal, D Rodman, AB Goldfine, FC Kuo, ... New England journal of medicine 360 (15), 1509-1517, 2009 | 5202 | 2009 |
Critical nodes in signalling pathways: insights into insulin action CM Taniguchi, B Emanuelli, CR Kahn Nature reviews Molecular cell biology 7 (2), 85-96, 2006 | 3570 | 2006 |
Role of brain insulin receptor in control of body weight and reproduction JC Bruning, D Gautam, DJ Burks, J Gillette, M Schubert, PC Orban, ... Science 289 (5487), 2122-2125, 2000 | 2733 | 2000 |
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 ME Patti, AJ Butte, S Crunkhorn, K Cusi, R Berria, S Kashyap, Y Miyazaki, ... Proceedings of the national academy of sciences 100 (14), 8466-8471, 2003 | 2442 | 2003 |
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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein XJ Sun, P Rothenberg, CR Kahn, JM Backer, E Araki, PA Wilden, ... Nature 352 (6330), 73-77, 1991 | 2056 | 1991 |
Developmental origin of fat: tracking obesity to its source S Gesta, YH Tseng, CR Kahn Cell 131 (2), 242-256, 2007 | 2047 | 2007 |
Antioxidants prevent health-promoting effects of physical exercise in humans M Ristow, K Zarse, A Oberbach, N Klöting, M Birringer, M Kiehntopf, ... Proceedings of the National Academy of Sciences 106 (21), 8665-8670, 2009 | 1958 | 2009 |
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Insulin receptor signaling in normal and insulin-resistant states J Boucher, A Kleinridders, CR Kahn Cold Spring Harbor perspectives in biology 6 (1), a009191, 2014 | 1725 | 2014 |
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study BC Martin, JH Warram, AS Krolewski, JS Soeldner, CR Kahn, ... The Lancet 340 (8825), 925-929, 1992 | 1687 | 1992 |
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, ... Molecular cell 6 (1), 87-97, 2000 | 1638 | 2000 |
Extended longevity in mice lacking the insulin receptor in adipose tissue M Bluher, BB Kahn, CR Kahn Science 299 (5606), 572-574, 2003 | 1635 | 2003 |
Insulin resistance differentially affects the PI 3-kinase–and MAP kinase–mediated signaling in human muscle K Cusi, K Maezono, A Osman, M Pendergrass, ME Patti, T Pratipanawatr, ... The Journal of clinical investigation 105 (3), 311-320, 2000 | 1606 | 2000 |
Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes RN Kulkarni, JC Brüning, JN Winnay, C Postic, MA Magnuson, CR Kahn Cell 96 (3), 329-339, 1999 | 1513 | 1999 |