Robert A. Saxton
Robert A. Saxton
Assistant Professor, UC Berkeley
Verified email at
Cited by
Cited by
mTOR signaling in growth, metabolism, and disease
RA Saxton, DM Sabatini
Cell 168 (6), 960-976, 2017
Sestrin2 is a leucine sensor for the mTORC1 pathway
RL Wolfson, L Chantranupong, RA Saxton, K Shen, SM Scaria, JR Cantor, ...
Science 351 (6268), 43-48, 2016
The CASTOR proteins are arginine sensors for the mTORC1 pathway
L Chantranupong, SM Scaria, RA Saxton, MP Gygi, K Shen, GA Wyant, ...
Cell 165 (1), 153-164, 2016
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
X Gu, JM Orozco, RA Saxton, KJ Condon, GY Liu, PA Krawczyk, ...
Science 358 (6364), 813-818, 2017
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
L Chantranupong, RL Wolfson, JM Orozco, RA Saxton, SM Scaria, ...
Cell reports 9 (1), 1-8, 2014
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
RA Saxton, KE Knockenhauer, RL Wolfson, L Chantranupong, ME Pacold, ...
Science 351 (6268), 53-58, 2016
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
RA Saxton, L Chantranupong, KE Knockenhauer, TU Schwartz, ...
Nature 536 (7615), 229-233, 2016
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
K Mohan, G Ueda, AR Kim, KM Jude, JA Fallas, Y Guo, M Hafer, Y Miao, ...
Science 364 (6442), eaav7532, 2019
Structure-based decoupling of the pro-and anti-inflammatory functions of interleukin-10
RA Saxton, N Tsutsumi, LL Su, GC Abhiraman, K Mohan, LT Henneberg, ...
Science 371 (6535), eabc8433, 2021
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
CR Glassman, N Tsutsumi, RA Saxton, PJ Lupardus, KM Jude, KC Garcia
Science 376 (6589), 163-169, 2022
Dimerization quality control ensures neuronal development and survival
EL Mena, RAS Kjolby, RA Saxton, A Werner, BG Lew, JM Boyle, ...
Science 362 (6411), eaap8236, 2018
Emerging principles of cytokine pharmacology and therapeutics
RA Saxton, CR Glassman, KC Garcia
Nature Reviews Drug Discovery 22 (1), 21-37, 2023
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
RA Saxton, LT Henneberg, M Calafiore, L Su, KM Jude, AM Hanash, ...
Immunity 54 (4), 660-672. e9, 2021
Structure of the nutrient-sensing hub GATOR2
ML Valenstein, KB Rogala, PV Lalgudi, EJ Brignole, X Gu, RA Saxton, ...
Nature 607 (7919), 610-616, 2022
The apo-structure of the leucine sensor Sestrin2 is still elusive
RA Saxton, KE Knockenhauer, TU Schwartz, DM Sabatini
Science signaling 9 (446), ra92-ra92, 2016
Structural basis of Janus kinase trans-activation
NA Caveney, RA Saxton, D Waghray, CR Glassman, N Tsutsumi, ...
Cell reports 42 (3), 2023
Structural insights into the mechanism of leptin receptor activation
RA Saxton, NA Caveney, MD Moya-Garzon, KD Householder, ...
Nature Communications 14 (1), 1797, 2023
Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineering
RA Saxton, KC Garcia
The FEBS journal 289 (24), 8032-8036, 2022
Methods of identifying modulators of sestrin-gator-2 interaction for modulating mTORC1 activity
DM Sabatini, L Chantranupong, RL Wolfson, J Orozco, RA Saxton, ...
US Patent 10,168,338, 2019
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling
NA Caveney, GE Rodriguez, C Pollmann, T Meyer, MT Borowska, ...
Molecular Cell, 2024
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