Kalyan Das
Kalyan Das
Professor, Rega Institute, KU Leuven, Belgium
Bestätigte E-Mail-Adresse bei - Startseite
Zitiert von
Zitiert von
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition
SG Sarafianos, B Marchand, K Das, DM Himmel, MA Parniak, SH Hughes, ...
Journal of molecular biology 385 (3), 693-713, 2009
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that …
K Das, AD Clark, PJ Lewi, J Heeres, MR De Jonge, LMH Koymans, ...
Journal of medicinal chemistry 47 (10), 2550-2560, 2004
Crystal structure of HIV‐1 reverse transcriptase in complex with a polypurine tract RNA: DNA
SG Sarafianos, K Das, C Tantillo, AD ClarkJr, J Ding, JM Whitcomb, ...
The EMBO journal, 2001
Structures of influenza A proteins and insights into antiviral drug targets
K Das, JM Aramini, LC Ma, RM Krug, E Arnold
Nature structural & molecular biology 17 (5), 530-538, 2010
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
J Ding, K Das, H Moereels, L Koymans, K Andries, PAJ Janssen, ...
Nature structural biology 2 (5), 407-415, 1995
In Search of a Novel Anti-HIV Drug:  Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl …
PAJ Janssen, PJ Lewi, E Arnold, F Daeyaert, M De Jonge, J Heeres, ...
Journal of medicinal chemistry 48 (6), 1901-1909, 2005
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2 …
J Ding, K Das, Y Hsiou, SG Sarafianos, AD Clark Jr, A Jacobo-Molina, ...
Journal of molecular biology 284 (4), 1095-1111, 1998
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations
K Das, JD Bauman, AD Clark Jr, YV Frenkel, PJ Lewi, AJ Shatkin, ...
Proceedings of the National Academy of Sciences 105 (5), 1466-1471, 2008
Structure of unliganded HIV-1 reverse transcriptase at 2.7 Å resolution: implications of conformational changes for polymerization and inhibition mechanisms
Y Hsiou, J Ding, K Das, AD Clark Jr, SH Hughes, E Arnold
Structure 4 (7), 853-860, 1996
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids
SG Sarafianos, K Das, AD Clark Jr, J Ding, PL Boyer, SH Hughes, ...
Proceedings of the national academy of sciences 96 (18), 10027-10032, 1999
The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro
WE Delaney IV, H Yang, CE Westland, K Das, E Arnold, CS Gibbs, ...
Journal of virology 77 (21), 11833-11841, 2003
Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC)
K Das, X Xiong, H Yang, CE Westland, CS Gibbs, SG Sarafianos, ...
Journal of virology 75 (10), 4771-4779, 2001
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant
K Das, J Ding, Y Hsiou, AD Clark Jr, H Moereels, L Koymans, K Andries, ...
Journal of molecular biology 264 (5), 1085-1100, 1996
Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse …
K Das, PJ Lewi, SH Hughes, E Arnold
Progress in biophysics and molecular biology 88 (2), 209-231, 2005
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues
DW Ludovici, BL De Corte, MJ Kukla, H Ye, CY Ho, MA Lichtenstein, ...
Bioorganic & medicinal chemistry letters 11 (17), 2235-2239, 2001
Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 Å resolution
J Ding, K Das, C Tantillo, W Zhang, AD Clark Jr, S Jessen, X Lu, Y Hsiou, ...
Structure 3 (4), 365-379, 1995
The RNA polymerase “switch region” is a target for inhibitors
J Mukhopadhyay, K Das, S Ismail, D Koppstein, M Jang, B Hudson, ...
Cell 135 (2), 295-307, 2008
Structures of HIV‐1 reverse transcriptase with pre‐and post‐translocation AZTMP‐terminated DNA
SG Sarafianos, AD ClarkJr, K Das, S Tuske, JJ Birktoft, P Ilankumaran, ...
The EMBO journal, 2002
Structural basis for suppression of a host antiviral response by influenza A virus
K Das, LC Ma, R Xiao, B Radvansky, J Aramini, L Zhao, J Marklund, ...
Proceedings of the National Academy of Sciences 105 (35), 13093-13098, 2008
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
Y Hsiou, J Ding, K Das, AD Clark Jr, PL Boyer, P Lewi, PAJ Janssen, ...
Journal of molecular biology 309 (2), 437-445, 2001
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