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Karl H. Clodfelter
Karl H. Clodfelter
Consultant
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Titel
Zitiert von
Zitiert von
Jahr
Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male …
KH Clodfelter, MG Holloway, P Hodor, SH Park, WJ Ray, DJ Waxman
Molecular endocrinology 20 (6), 1333-1351, 2006
2392006
Predictome: a database of putative functional links between proteins
JC Mellor, I Yanai, KH Clodfelter, J Mintseris, C DeLisi
Nucleic Acids Research 30 (1), 306-309, 2002
2052002
Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis
A Ahluwalia, KH Clodfelter, DJ Waxman
Molecular Endocrinology 18 (3), 747-760, 2004
1702004
Optimal clustering for detecting near-native conformations in protein docking
D Kozakov, KH Clodfelter, S Vajda, CJ Camacho
Biophysical journal 89 (2), 867-875, 2005
1562005
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors
X Zheng, P Bauer, T Baumeister, AJ Buckmelter, M Caligiuri, ...
Journal of medicinal chemistry 56 (16), 6413-6433, 2013
120*2013
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors
X Zheng, P Bauer, T Baumeister, AJ Buckmelter, M Caligiuri, ...
Journal of medicinal chemistry 56 (16), 6413-6433, 2013
120*2013
Identification of substrate binding sites in enzymes by computational solvent mapping
M Silberstein, S Dennis, L Brown III, T Kortvelyesi, K Clodfelter, S Vajda
Journal of molecular biology 332 (5), 1095-1113, 2003
962003
Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis
KH Clodfelter, GD Miles, V Wauthier, MG Holloway, X Zhang, P Hodor, ...
Physiological genomics 31 (1), 63-74, 2007
762007
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors
X Zheng, P Bauer, T Baumeister, AJ Buckmelter, M Caligiuri, ...
Journal of medicinal chemistry 56 (12), 4921-4937, 2013
642013
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties
J Gunzner-Toste, G Zhao, P Bauer, T Baumeister, AJ Buckmelter, ...
Bioorganic & medicinal chemistry letters 23 (12), 3531-3538, 2013
432013
Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450
KH Clodfelter, DJ Waxman, S Vajda
Biochemistry 45 (31), 9393-9407, 2006
432006
Identification of amides derived from 1H-pyrazolo [3, 4-b] pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
X Zheng, KW Bair, P Bauer, T Baumeister, KK Bowman, AJ Buckmelter, ...
Bioorganic & medicinal chemistry letters 23 (20), 5488-5497, 2013
412013
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility
M Zak, BM Liederer, D Sampath, P Yuen, KW Bair, T Baumeister, ...
Bioorganic & medicinal chemistry letters 25 (3), 529-541, 2015
282015
Compounds and compositions for the inhibition of NAMPT
KW Bair, T Baumeister, AJ Buckmelter, KH Clodfelter, B Han, J Lin, ...
US Patent 9,169,209, 2015
25*2015
Novel compounds and compositions for the inhibition of nampt
KW Bair, TR Baumeister, AJ Buckmelter, KH Clodfelter, P Dragovich, ...
US Patent App. 13/820,497, 2014
242014
Novel compounds and compositions for the inhibition of nampt
KW Bair, TR Baumeister, AJ Buckmelter, KH Clodfelter, B Han, J Lin, ...
US Patent App. 13/820,496, 2013
222013
Novel compounds and compositions for the inhibition of nampt
KW Bair, TR Baumeister, AJ Buckmelter, KH Clodfelter, B Han, J Lin, ...
US Patent App. 13/820,496, 2013
222013
Novel compounds and compositions for the inhibition of nampt
KW Bair, TR Baumeister, AJ Buckmelter, KH Clodfelter, B Han, J Lin, ...
US Patent App. 13/820,496, 2013
222013
Compounds and compositions for the inhibition of NAMPT
KW Bair, TR Baumeister, AJ Buckmelter, KH Clodfelter, P Dragovich, ...
US Patent 10,272,072, 2019
202019
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors
X Zheng, T Baumeister, AJ Buckmelter, M Caligiuri, KH Clodfelter, B Han, ...
Bioorganic & medicinal chemistry letters 24 (1), 337-343, 2014
192014
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