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Philippe Nuhant
Philippe Nuhant
Senior Research Scientist at Vertex Pharmaceuticals
Bestätigte E-Mail-Adresse bei vrtx.com
Titel
Zitiert von
Zitiert von
Jahr
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand
LA Solt, N Kumar, P Nuhant, Y Wang, JL Lauer, J Liu, MA Istrate, ...
Nature 472 (7344), 491-494, 2011
5732011
Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds
RR Merchant, JT Edwards, T Qin, MM Kruszyk, C Bi, G Che, DH Bao, ...
Science 360 (6384), 75-80, 2018
1832018
Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ
Y Wang, N Kumar, P Nuhant, MD Cameron, MA Istrate, WR Roush, ...
ACS chemical biology 5 (11), 1029-1034, 2010
1732010
Visible‐Light‐Initiated Manganese Catalysis for C− H Alkylation of Heteroarenes: Applications and Mechanistic Studies
P Nuhant, MS Oderinde, J Genovino, A Juneau, Y Gagné, C Allais, ...
Angewandte Chemie International Edition 56 (48), 15309-15313, 2017
1692017
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist
N Kumar, DJ Kojetin, LA Solt, KG Kumar, P Nuhant, DR Duckett, ...
ACS chemical biology 6 (3), 218-222, 2011
1232011
Visible-light-driven photocatalytic initiation of radical thiol–ene reactions using bismuth oxide
OO Fadeyi, JJ Mousseau, Y Feng, C Allais, P Nuhant, MZ Chen, B Pierce, ...
Organic letters 17 (23), 5756-5759, 2015
882015
α, α ‘-annulation of 2, 6-prenyl-substituted cyclohexanone derivatives with malonyl chloride: application to a short synthesis of (±)-clusianone. formation and rearrangement of …
P Nuhant, M David, T Pouplin, B Delpech, C Marazano
Organic letters 9 (2), 287-289, 2007
822007
Generation of stereochemically defined tetrasubstituted enolborinates by 1, 4-hydroboration of α, β-unsaturated morpholine carboxamides with (diisopinocampheyl) borane.
C Allais, AS Tsai, P Nuhant, WR Roush
Angewandte Chemie 125 (49), 2013
542013
Electrochemically enabled chan–lam couplings of aryl boronic acids and anilines
RP Wexler, P Nuhant, TJ Senter, ZJ Gale-Day
Organic letters 21 (12), 4540-4543, 2019
482019
Further insight from model experiments into a possible scenario concerning the origin of manzamine alkaloids
JC Wypych, TM Nguyen, P Nuhant, M Bénéchie, C Marazano
Angewandte Chemie International Edition 47 (29), 5418-5421, 2008
482008
Enantio- and Diastereoselective Synthesis of (E)-1,5-syn-Diols: Application to the Synthesis of the C(23)−C(40) Fragment of Tetrafibricin
J Kister, P Nuhant, R Lira, A Sorg, WR Roush
Organic letters 13 (7), 1868-1871, 2011
462011
Antiproliferation activity of a small molecule repressor of liver receptor homolog 1
CA Corzo, Y Mari, MR Chang, T Khan, D Kuruvilla, P Nuhant, N Kumar, ...
Molecular pharmacology 87 (2), 296-304, 2015
452015
Irradiation-induced palladium-catalyzed direct C–H alkylation of heteroarenes with tertiary and secondary alkyl bromides
GZ Wang, R Shang, Y Fu
Synthesis 50 (15), 2908-2914, 2018
422018
(Diisopinocampheyl) borane-Mediated Reductive Aldol Reactions: Highly Enantio and Diastereoselective Synthesis of Syn-Aldols from N-Acryloylmorpholine
P Nuhant, C Allais, WR Roush
Angewandte Chemie (International ed. in English) 52 (33), 2013
392013
C–H Functionalization of heteroarenes using unactivated alkyl halides through visible-light photoredox catalysis under basic conditions
NB Bissonnette, MJ Boyd, GD May, S Giroux, P Nuhant
The Journal of Organic Chemistry 83 (18), 10933-10940, 2018
382018
New avenues in radical trifluoromethylselenylation with trifluoromethyl tolueneselenosulfonate
C Ghiazza, C Monnereau, L Khrouz, M Médebielle, T Billard, A Tlili
Synlett 30 (07), 777-782, 2019
352019
Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally …
ME Schnute, M Wennerstål, J Alley, M Bengtsson, JR Blinn, CW Bolten, ...
Journal of Medicinal Chemistry 61 (23), 10415-10439, 2018
312018
Enantio- and Diastereoselective Synthesis of N-Acetyl Dihydrotetrafibricin Methyl Ester
P Nuhant, WR Roush
Journal of the American Chemical Society 135 (14), 5340-5343, 2013
302013
Synthesis of polyprenylated benzoylphloroglucinols by regioselective prenylation of phloroglucinol in an aqueous medium
SB Raikar, P Nuhant, B Delpech, C Marazano
European Journal of Organic Chemistry 2008 (8), 1358-1369, 2008
302008
Enhancement of 5-Aminopenta-2,4-dienals Electrophilicity via Activation by O,N-Bistrifluoroacetylation. Application to an N-Acyl Pictet−Spengler Reaction
P Nuhant, SB Raikar, JC Wypych, B Delpech, C Marazano
The Journal of Organic Chemistry 74 (24), 9413-9421, 2009
282009
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