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Bart Roep
Bart Roep
Leiden University Medical Center
Verified email at lumc.nl
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Cited by
Year
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
JC Barrett, DG Clayton, P Concannon, B Akolkar, JD Cooper, HA Erlich, ...
Nature genetics 41 (6), 703-707, 2009
21352009
Defective suppressor function in CD4+ CD25+ T-cells from patients with type 1 diabetes
S Lindley, CM Dayan, A Bishop, BO Roep, M Peakman, TIM Tree
Diabetes 54 (1), 92-99, 2005
11392005
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families
H Erlich, AM Valdes, J Noble, JA Carlson, M Varney, P Concannon, ...
Diabetes 57 (4), 1084-1092, 2008
9052008
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
KT Coppieters, F Dotta, N Amirian, PD Campbell, TWH Kay, MA Atkinson, ...
Journal of Experimental Medicine 209 (1), 51-60, 2012
7222012
Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
F Dotta, S Censini, AGS van Halteren, L Marselli, M Masini, S Dionisi, ...
Proceedings of the National Academy of Sciences 104 (12), 5115-5120, 2007
7202007
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
S Onengut-Gumuscu, WM Chen, O Burren, NJ Cooper, AR Quinlan, ...
Nature genetics 47 (4), 381-386, 2015
6702015
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
S Arif, TI Tree, TP Astill, JM Tremble, AJ Bishop, CM Dayan, BO Roep, ...
The Journal of clinical investigation 113 (3), 451-463, 2004
5832004
Induction of Treg by monocyte‐derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD‐L1
WWJ Unger, S Laban, FS Kleijwegt, AR van der Slik, BO Roep
European journal of immunology 39 (11), 3147-3159, 2009
5072009
The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure
BO Roep
Diabetologia 46, 305-321, 2003
5072003
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
A Skowera, RJ Ellis, R Varela-Calviño, S Arif, GC Huang, C Van-Krinks, ...
The Journal of clinical investigation 118 (10), 3390-3402, 2008
4542008
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
JP Bradfield, HQ Qu, K Wang, H Zhang, PM Sleiman, CE Kim, FD Mentch, ...
PLoS genetics 7 (9), e1002293, 2011
3872011
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
BO Roep, S Thomaidou, R van Tienhoven, A Zaldumbide
Nature Reviews Endocrinology 17 (3), 150-161, 2021
3642021
Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes
GGM Pinkse, OHM Tysma, CAM Bergen, MGD Kester, F Ossendorp, ...
Proceedings of the National Academy of Sciences 102 (51), 18425-18430, 2005
3572005
Development of type 1 diabetes despite severe hereditary B-cell deficiency
S Martin, D Wolf-Eichbaum, G Duinkerken, WA Scherbaum, H Kolb, ...
New England Journal of Medicine 345 (14), 1036-1040, 2001
3532001
Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials
A Moran, B Bundy, DJ Becker, LA DiMeglio, SE Gitelman, R Goland, ...
The Lancet 381 (9881), 1905-1915, 2013
3512013
Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes
TP Di Lorenzo, M Peakman, BO Roep
Clinical & Experimental Immunology 148 (1), 1-16, 2007
3122007
Antigen targets of type 1 diabetes autoimmunity
BO Roep, M Peakman
Cold Spring Harbor perspectives in medicine 2 (4), a007781, 2012
3032012
The vitamin D receptor gene FokI polymorphism: Functional impact on the immune system
E van Etten, L Verlinden, A Giulietti, E Ramos‐Lopez, DD Branisteanu, ...
European journal of immunology 37 (2), 395-405, 2007
2982007
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
JA Noble, AM Valdes, MD Varney, JA Carlson, P Moonsamy, AL Fear, ...
Diabetes 59 (11), 2972-2979, 2010
2912010
KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects
AR van der Slik, BPC Koeleman, W Verduijn, GJ Bruining, BO Roep, ...
Diabetes 52 (10), 2639-2642, 2003
2882003
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