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Bede Portz
Bede Portz
Associate Principal Scientist, Dewpoint Therapeutics
Verified email at dewpointx.com
Title
Cited by
Cited by
Year
RNA binding antagonizes neurotoxic phase transitions of TDP-43
JR Mann, AM Gleixner, JC Mauna, E Gomes, MR DeChellis-Marks, ...
Neuron 102 (2), 321-338. e8, 2019
3892019
FUS and TDP-43 Phases in Health and Disease
B Portz, BL Lee, J Shorter
Trends in Biochemical Sciences, 2021
1572021
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
M Hallegger, AM Chakrabarti, FCY Lee, BL Lee, AG Amalietti, HM Odeh, ...
Cell 184 (18), 4680-4696. e22, 2021
1262021
CRISPR-Cas9 screens identify the RNA helicase DDX3X as a repressor of C9ORF72 (GGGGCC) n repeat-associated non-AUG translation
W Cheng, S Wang, Z Zhang, DW Morgens, LR Hayes, S Lee, B Portz, ...
Neuron 104 (5), 885-898. e8, 2019
1132019
Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
EB Gibbs, F Lu, B Portz, MJ Fisher, BP Medellin, TN Laremore, YJ Zhang, ...
Nature Communications 8 (1), 15233, 2017
812017
Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
B Portz, F Lu, EB Gibbs, JE Mayfield, M Rachel Mehaffey, YJ Zhang, ...
Nature communications 8 (1), 15231, 2017
712017
The C-terminal domain of RNA polymerase II is a multivalent targeting sequence that supports drosophila development with only consensus heptads
F Lu, B Portz, DS Gilmour
Molecular cell 73 (6), 1232-1242. e4, 2019
542019
Biochemical timekeeping via reentrant phase transitions
B Portz, J Shorter
Journal of Molecular Biology, 2020
252020
Switching condensates: the CTD code goes liquid
B Portz, J Shorter
Trends in Biochemical Sciences 45 (1), 1-3, 2020
212020
Phase separation in biology and disease; current perspectives and open questions
S Boeynaems, S Chong, J Gsponer, L Holt, D Milovanovic, DM Mitrea, ...
Journal of molecular biology 435 (5), 167971, 2023
152023
RNA sequence and structure control assembly and function of RNA condensates
RR Poudyal, JP Sieg, B Portz, CD Keating, PC Bevilacqua
RNA 27 (12), 1589-1601, 2021
142021
3′ UTRs in the eye of the TIGER
B Portz, J Shorter
Developmental Cell 47 (5), 544-546, 2018
22018
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
L Guo, JR Mann, JC Mauna, KE Copley, H Wang, JD Rubien, HM Odeh, ...
bioRxiv, 2023.09. 04.555754, 2023
12023
Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain
EB Gibbs, TN Laremore, GA Usher, B Portz, EC Cook, SA Showalter
Biophysical journal 113 (9), 1909-1911, 2017
12017
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
KM Sweeney, S Chantarawong, EM Barbieri, G Cajka, M Liu, L Spruce, ...
Plos Genetics 20 (2), e1011138, 2024
2024
Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription
Q Zhang, W Kim, S Panina, JE Mayfield, B Portz, YJ Zhang
bioRxiv, 2024
2024
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